Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities
Loading...
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Research
Series Info
Scientific Reports ; volume 16 , Article number: 8501 , (2026)
Scientific Journal Rankings
Orcid
Abstract
This study presents the synthesis and comprehensive characterization of four novel metal-complexes formed from the reaction of copper(II), nickel(II), zinc(II), and vanadium(IV) salts with the bidentate ibuprofen Schiff base ligand (HL) in 1:1 metal-to-ligand ratio. The copper complex shows the highest antibacterial and cytotoxicity efficiency, in addition to a strong binding interactions with DNA. The in-vitro anti-inflammatory and anti-COVID-19 potencies of HL and its complexes were assessed, ranking them as: CuL > NiL > ZnL > VOL > HL.
Description
SJR 2024
0.874
Q1
H-Index
347
Subject Area and Category:
Multidisciplinary
Multidisciplinary
Keywords
Citation
Abdel-Rahman, L. H., El-ezz, D. A., Abdel-Mawgoud, A.-M. M., Shehata, M. R., El-Remaily, M. A. E. A. A. A., Abdel-Hameed, M., & Mohamed, S. K. (2026). Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities. Scientific Reports, 16(1). https://doi.org/10.1038/s41598-026-38270-8