MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 138
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RESEARCH & LANGUAGES CENTERS 18

Recent Submissions

Combination Therapy Using Bilosome–Chitosan Nanocarriers for Effective Drug Delivery of Daclatasvir and Xanthone in COVID-19 and Acute Respiratory Distress Syndrome: A Preclinical Assessment
(Springer New York, 2026-01-04) Marwa H. S. Dawoud; Heba T. Elbalkiny; Amr Abdelhamid; Mai A. Amer; Reham Wasfi; Mai A. Zaafan1
Purpose: COVID-19 pandemic has driven the urgent need for effective antiviral treatments and strategies to combat its life-threatening complications. This study aims to develop a combination therapy approach using daclatasvir, as an antiviral agent, and xanthone, as a potent anti-inflammatory and antithrombotic compound, delivered via Bilosome-Chitosan Nanoparticles (BCNP). Methods: The impact of varying the bilosome-to-chitosan ratio on the particle size (PS), zeta potential (ZP), and encapsulation efficiency (EE%) was evaluated. An optimized formula was prepared and tested for its antiviral activity and its potential for pulmonary protection in acute respiratory distress syndrome (ARDS) on mice model. Results: The optimized formulation (O1) showed a PS of 222.67 nm, a polydispersity index of 0.368, a ZP of -19.10 mV, and EE% of 83.78% for xanthone and 78.98% for daclatasvir. Controlled release profiles were attained, with daclatasvir released over 24 h and xanthone sustained for up to 72 h. The optimized formula showed promising deposition lung profile when tested using MPPD modelling. O1 demonstrated strong antiviral activity against SARS-CoV-2, with a selectivity index (SI = 5.02) and an IC50 of 3.87 µM. Additionally, the formulation exhibited pulmonary protective effects by modulating the LncGAS5/ACE2 pathway, with significant improvements in the lungs of the mice model, offering a potential therapeutic strategy against ARDS, a severe and often fatal COVID-19 complication. Conclusion: A successful BCNP formulation combining daclatasvir and xanthone was prepared, providing a promising combination therapy approach for COVID-19 treatment and ARDS prevention.
Fractographic analysis of 3D printed hybrid ceramic single crowns with different aging and post-curing times: an in-vitro study
(Nature Research, 2025-12-26) Salma Hatem; Bassem Emad; Nermeen Nagi; Aliaa Ibrahim Mahrous
Since increasing 3D-printed ceramics are being introduced to restorative dentistry, a critical evaluation of fabrication parameters for optimal clinical performance is necessary. While post-curing treatments have some influence on material properties, their impact on fracture resistance is not clear. This in vitro study aimed to systematically evaluate the effects of different post-curing times (10 vs. 20 min) and thermocycling aging (5,000 vs. 10,000 cycles) on the fracture resistance and failure modes of 3D-printed hybrid ceramic crowns (Saremco CrownTec). CAD software was utilized to create a standardized digital model of a mandibular first premolar crown. Eighty identical samples were produced with a high-precision 3D printer (Asiga Max UV) using Saremco Print Crowntec hybrid ceramic material. Samples were randomly allocated to two major groups according to post-curing time in a UV polymerization unit (10 min vs. 20 min). Each group was then assigned to two subgroups (n = 20 each) for thermocycling treatment (5,000 or 10,000 cycles between 5 °C and 55 °C). All crowns were adhesively cemented on PEEK dies with standardized preparation geometry. Fracture resistance testing was accomplished with a universal testing machine (Instron 5966) using a 5.6 mm steel ball indenter at 0.5 mm/min crosshead speed. Failure modes were examined using scanning electron microscopy SEM. Statistical analysis was conducted using two-way ANOVA (α = 0.05). The 10-minute post-cure group showed slightly greater mean fracture resistance (506.36 ± 58.44 N) than the 20-minute group (492.50 ± 76.06 N), but the difference was not statistically significant (p = 0.428). Thermocycling analysis showed that specimens that underwent 5,000 cycles had slightly better fracture resistance (510.00 ± 72.36 N) than those which underwent 10,000 cycles (488.26 ± 62.64 N), but the difference was also not statistically significant (p = 0.250). The failure patterns were reported and analyzed with SEM, based on extensions of failures on the axial surface. Although long post-curing times and thermocycling aging exhibited tendencies for decreased fracture resistance, the effects were not statistically significant under the parameters tested. Research in the future should examine the influence of various post-curing intensities and extended aging simulations to further support these results.
TRANSFORMERS IN ARABIC SHORT ANSWER GRADING: BRIDGING LINGUISTIC COMPLEXITY WITH DEEP LEARNING
(Little Lion Scientific, 2025-11-30) WAEL HASSAN GOMAA; MENA HANY; EMAD NABIL; ABDELRAHMAN E. NAGIB; HALA ABDEL HAMEED
Automating the evaluation of Arabic short answers is a crucial step in advancing educational technology, as it enables rapid feedback, consistent scoring, and a significant reduction in educators’ workload. However, the structural richness and semantic complexity of Arabic—characterized by its extensive morphology, flexible word order, and diverse vocabulary—make reliable grading especially challenging. To address these difficulties, this study introduces a three-stage framework built upon fine-tuned transformer architectures. In the first stage, both the question and the learner’s response are encoded into dense semantic embeddings. The second stage applies comprehensive fine-tuning to a pre-trained transformer model, allowing it to capture task-specific nuances and better represent the intricate patterns of Arabic. In the final stage, a regression layer generates a numerical score, which is then compared against the human-assigned reference grade for evaluation. The proposed framework was rigorously tested on two benchmark datasets for Arabic short answer grading, AR-ASAG and Philosophy. Experimental results demonstrated strong performance, achieving Pearson correlation scores of 0.85 and 0.97, respectively, and outperforming previously reported state-of-the-art methods. These outcomes confirm the effectiveness of transformer-based models in handling the linguistic subtleties of Arabic while also demonstrating their scalability and adaptability across domains. Overall, the findings position fine-tuned transformers as a promising foundation for building accurate, efficient, and equitable automated grading systems in Arabic educational contexts.
Progressive applications of synthesized isatin-based reactive dye: fabrics dyeing, corrosion inhibition, and antimicrobial activity
(Nature Research, 2025-12-23) Mervat El-Sedik; Saadia Abd Elmegied; Tarek Aysha; Amal M.Abdel-karim; Bassant Gaber; Safia A. Mahmoud
A new heterobis- reactive dye, monochlorotriazine/sulphatoethylsulphone bearing an isatin moiety (MCT-SES dye), was synthesized and identified using NMR, mass spectra, and elemental analysis. The prepared reactive dye showed an absorption band at 543 nm. The dyeing properties on cotton and wool fabrics were investigated at different concentrations and pH levels, showing excellent dye affinity toward both fabrics. The dyed fabrics exhibited excellent wash fastness, rubbing fastness, perspiration fastness, and good light stability. In 1.0 M hydrochloric acid solution, the isatin-based MCT-SES dye exhibited unique corrosion inhibition performance for carbon steel (CS). Energy dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization (PDP) were the methods used to assess the inhibitory efficacy and development of a protective film on the steel surface. With increasing dye concentration, the corrosion inhibition efficiency increased, reaching a maximum of 98.64% at 500 ppm. The excellent performance was attributed to strong adsorption and the formation of a dense, protective barrier film on the steel surface. The MCT-SES dye demonstrated strong antibacterial action against P. aeruginosa (23 ± 0.23 mm) and E. coli (20 ± 0.34 mm). The inhibition of the bacteria growing on the surface of the dyed fabrics was investigated by scanning electron microscope (SEM), which proves the high affinity of the dyed fabric against bacteria growth. Molecular docking simulations and the binding interaction of the dye structure with the bacteria protein were investigated.
Accuracy assessment of intraoral scanning versus conventional impressions in edentulous patients with flabby ridges: a prospective clinical study
(The Korean Academy of prosthodontics, 2025-12-15) Dina Mohamed Elawady; Ahmed Yehia Abdel-Moneim; Ahmed Yaseen Alqutaibi; Sherin Samir Matta
PURPOSE: This prospective clinical study aimed to evaluate the accuracy of intraoral scanning (IOS) as an alternative to the conventional window technique impression (WTI) for recording maxillary flabby ridges in edentulous patients. MATERIALS AND METHODS: Twelve edentulous participants with maxillary flabby ridges underwent both IOS (TRIOS 5, 3Shape, Denmark) and WTI. WTI impressions were made using zinc oxide-eugenol paste and plaster of Paris as the reference. All scans were exported in STL format. Accuracy was assessed via trueness and precision, using RMS, average negative, and average positive deviations, calculated with Medit Compare software. RESULTS: IOS showed significantly higher trueness than WTI in RMS (mean difference (MD) = -0.11, 95% CI: -0.15 to -0.06, P =. 0001) and average negative deviation (MD = 0.13, 95% CI: 0.07 to 0.19, P =. 0001). The average positive deviation had no significant difference (MD = 0.02, 95% CI: -0.01 to 0.05, P =. 11). In terms of precision, IOS had significantly higher precision across all parameters: RMS (MD = 0.23, 95% CI: 0.21 to 0.26, P =. 0001), average positive deviation (MD = 0.14, 95% CI: 0.11 to 0.17, P =. 0001), and average negative deviation (MD = -0.15, 95% CI: -0.17 to -0.13, P =. 0001). CONCLUSION: This study suggests that IOS may provide improved accuracy compared to the conventional window impression technique for capturing maxillary flabby ridges in edentulous patients. Further research with larger sample size and clinical outcome assessments is needed to confirm its efficacy.