MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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RESEARCH & LANGUAGES CENTERS 18

Recent Submissions

Progressive applications of synthesized isatin-based reactive dye: fabrics dyeing, corrosion inhibition, and antimicrobial activity
(Nature Research, 2025-12-23) Mervat El-Sedik; Saadia Abd Elmegied; Tarek Aysha; Amal M.Abdel-karim; Bassant Gaber; Safia A. Mahmoud
A new heterobis- reactive dye, monochlorotriazine/sulphatoethylsulphone bearing an isatin moiety (MCT-SES dye), was synthesized and identified using NMR, mass spectra, and elemental analysis. The prepared reactive dye showed an absorption band at 543 nm. The dyeing properties on cotton and wool fabrics were investigated at different concentrations and pH levels, showing excellent dye affinity toward both fabrics. The dyed fabrics exhibited excellent wash fastness, rubbing fastness, perspiration fastness, and good light stability. In 1.0 M hydrochloric acid solution, the isatin-based MCT-SES dye exhibited unique corrosion inhibition performance for carbon steel (CS). Energy dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization (PDP) were the methods used to assess the inhibitory efficacy and development of a protective film on the steel surface. With increasing dye concentration, the corrosion inhibition efficiency increased, reaching a maximum of 98.64% at 500 ppm. The excellent performance was attributed to strong adsorption and the formation of a dense, protective barrier film on the steel surface. The MCT-SES dye demonstrated strong antibacterial action against P. aeruginosa (23 ± 0.23 mm) and E. coli (20 ± 0.34 mm). The inhibition of the bacteria growing on the surface of the dyed fabrics was investigated by scanning electron microscope (SEM), which proves the high affinity of the dyed fabric against bacteria growth. Molecular docking simulations and the binding interaction of the dye structure with the bacteria protein were investigated.
Accuracy assessment of intraoral scanning versus conventional impressions in edentulous patients with flabby ridges: a prospective clinical study
(The Korean Academy of prosthodontics, 2025-12-15) Dina Mohamed Elawady; Ahmed Yehia Abdel-Moneim; Ahmed Yaseen Alqutaibi; Sherin Samir Matta
PURPOSE: This prospective clinical study aimed to evaluate the accuracy of intraoral scanning (IOS) as an alternative to the conventional window technique impression (WTI) for recording maxillary flabby ridges in edentulous patients. MATERIALS AND METHODS: Twelve edentulous participants with maxillary flabby ridges underwent both IOS (TRIOS 5, 3Shape, Denmark) and WTI. WTI impressions were made using zinc oxide-eugenol paste and plaster of Paris as the reference. All scans were exported in STL format. Accuracy was assessed via trueness and precision, using RMS, average negative, and average positive deviations, calculated with Medit Compare software. RESULTS: IOS showed significantly higher trueness than WTI in RMS (mean difference (MD) = -0.11, 95% CI: -0.15 to -0.06, P =. 0001) and average negative deviation (MD = 0.13, 95% CI: 0.07 to 0.19, P =. 0001). The average positive deviation had no significant difference (MD = 0.02, 95% CI: -0.01 to 0.05, P =. 11). In terms of precision, IOS had significantly higher precision across all parameters: RMS (MD = 0.23, 95% CI: 0.21 to 0.26, P =. 0001), average positive deviation (MD = 0.14, 95% CI: 0.11 to 0.17, P =. 0001), and average negative deviation (MD = -0.15, 95% CI: -0.17 to -0.13, P =. 0001). CONCLUSION: This study suggests that IOS may provide improved accuracy compared to the conventional window impression technique for capturing maxillary flabby ridges in edentulous patients. Further research with larger sample size and clinical outcome assessments is needed to confirm its efficacy.
Genomic prediction of phytase potential and stress tolerance in maize-associated plant growth-promoting rhizobacterium Enterobacter cloacae Mz49
(SpringerOpen, 2025-11-29) Mai A. Amer; Samira M. Hamed
The maize rhizobacterium Enterobacter cloacae Mz49 exhibits diverse plant growth-promoting and stress-adaptive traits, indicating strong potential for bioinoculant development. Mz49 was isolated from the Egyptian rhizosphere, and demonstrated in vitro production of indole-3-acetic acid (64.89 µg/mL), antioxidant activity (IC₅₀ = 11.71 µg/mL), and anti-inflammatory properties (IC₅₀ = 63.1 µg/mL). Whole-genome sequencing revealed a 5.34 Mb genome with 5,158 protein-coding genes linked to nutrient acquisition, abiotic stress tolerance, and secondary metabolite biosynthesis. Genes associated with nitrogen fixation (nirBD, ureABCDEFGJ, amtB), phosphate solubilization (pqqIFL, phoA, pstIPN), and phytohormone synthesis (iaaT, ysnE, ipdC, ppdC, amiE) were identified. Genome analysis also revealed phytase-related genes (agp, suhB), which contribute to the release of bioavailable phosphorus, an essential nutrient for maize growth. This genetic potential highlights the strain’s contribution to enhanced plant growth and nutrient-use efficiency, particularly under phosphorus-limited conditions. Additionally, stress-response genes (sodABC, katE, betB, proABCY, dnaJK, cspA) were identified, conferring resistance to oxidative, osmotic, thermal, and cold stresses. The presence of heavy metal resistance genes (arsenic, copper, zinc, nickel) suggests suitability for use in contaminated soils. AntiSMASH analysis identified biosynthetic gene clusters for siderophores, arylpolyenes, and non-ribosomal peptides. GC–MS profiling further detected bioactive compounds, including 2, 3-butanediol, D-pinitol, succinic acid, tyrosol, and azelaic acid, which are associated with plant growth promotion and defense responses. Collectively, these findings highlight Mz49’s potential for sustainable maize cultivation, particularly in phosphorus-limited or stress-prone soils. Future research should prioritize field trials to validate its efficacy and assess potential risks associated with its application.
Amygdalin synergizes with the TNF-α monoclonal antibody infiximab to modulate HSP90 and related necro-infammatory/oxidative stress pathways in a rat model of hepatic I/R
(Springer Science and Business Media Deutschland GmbH, 2025-12-17) Reem A. Mohamed; Mai El‑Sayed Ghoneim; Rasha A. Tawfq; Nermein F. El Sayed
Hepatic ischemia/reperfusion (I/R) injury remains a major limitation in liver surgery and transplantation. Amygdalin, a natural glycoside, is known for its antioxidant, anti-inflammatory, and hepatoprotective properties, but its combination with conventional agents is not studied. Accordingly, this study explores a combinatorial approach using a small dose of amygdalin (5 mg/kg) and low-dose infliximab (1.5 mg/kg), a tumor necrosis factor (TNF)-α inhibitor, as a pre-treatment to alleviate I/R-induced liver injury. It also investigates the unexamined role of heat shock protein (HSP)-90 in the modulation of necro-inflammatory pathways during hepatic ischemia/reperfusion injury. Rats were divided into six groups: sham, I/R, infliximab (1.5 and 3 mg/kg), amygdalin (5 mg/kg), and a combination of infliximab (1.5 mg/kg) with amygdalin. Treatments were administered intraperitoneally for three days before I/R induction. Both monotherapies and the combination significantly reduced hepatic expression of HSP90, TNF-α, and phosphorylated-mixed lineage kinase domain-like protein (p-MLKL), while restoring oxidative balance as evidenced by modulation of nuclear factor erythroid 2-related factor 2 (Nrf2), malondialdehyde (MDA), and superoxide dismutase (SOD). The combination therapy additionally suppressed nuclear factor kappa B (NF-κB) in a synergistic manner and enhanced Nrf2 expression compared to amygdalin monotherapy. Correlation analysis revealed strong associations between markers of necroinflammation and oxidative stress, reinforcing the mechanistic interplay between these pathways. HSP90 emerged in the current study as an intermediate modulator linking necroinflammation to oxidative responses. Importantly, the combined therapy exerted a synergistic effect by effectively modulating HSP90 and associated signaling cascades, underscoring its potential as a superior therapeutic strategy.
Rumex Species: Phytochemistry, Pharmacology and Nutritional Potential for Food and Health Applications
(John Wiley and Sons Ltd, 2025-12-19) Mai Mohamed Gohar; Shahira Mohamed Ezzat; Balakyz Yeskaliyeva; Seham Salaheldin Elhawary; Farid Noshey Kirollos; Aya Khouchlaa; Abdelhakim Bouyahya; Daniela Calina; Javad Sharifi-Rad; William N. Setzer; Miquel Martorell
The genus Rumex (Polygonaceae), comprising about 193 species, is widely distributed across temperate and subtropical regions of Europe, Asia, Africa, and North America, and has long been used in traditional medicine worldwide. These species are rich in diverse phytochemicals, including anthraquinones, flavonoids, tannins, naphthalenes, and stilbenes, which contribute to a broad range of biological activities. This review provides an updated synthesis of current knowledge on the taxonomy, phytochemistry, and pharmacological properties of Rumex species. Particular attention is given to R. dentatus, R. vesicarius and R. crispus, which exhibit antioxidant, anti-inflammatory, antimicrobial, hepatoprotective, antidiabetic, and anticancer effects in both in vitro and in vivo studies. Clinical and toxicological aspects, including oxalate accumulation and anthraquinone-associated adverse effects, are also discussed. Major research limitations include the lack of standardized extracts, insufficient clinical evidence, and poor bioavailability of key compounds. Enhancing bioavailability is vital because many bioactive compounds in Rumex are poorly absorbed and rapidly metabolized, which restricts their therapeutic potential. Environmental factors and phenological stages influencing phytochemical expression are highlighted as additional underexplored determinants of bioactivity. By integrating ethnopharmacological knowledge with experimental data, this review identifies future research priorities, including the optimization of formulation strategies, pharmacokinetic evaluation, and clinical validation. Collectively, these efforts may support the development of safe and effective Rumex-based nutraceuticals and therapeutic products.