MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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RESEARCH & LANGUAGES CENTERS 18

Recent Submissions

Ticagrelor as a dual RAS modulator and mitochondrial stabilizer: A multifaceted neurotherapeutic strategy in Huntington’s disease
(Elsevier Ltd, 2026-01-02) Ola E. Mohamed; Rabab H. Sayed; Dalaal M. Abdallah; Doaa Abou El-ezz; Amany El-Brairy; Hanan S. El-Abhar
The pathobiology of Huntington's disease (HD) is far from complete. Although limited, patients have been reported to exhibit altered platelet function, enhanced ENT1, and changes in renin–angiotensin system (RAS), all of which may impact cognitive function. Ticagrelor has demonstrated neuroprotective effects in stroke and parkinsonism models through mechanisms that extend beyond its therapeutic benefits as a P2Y12 receptor antagonist and ENT1 inhibitor. In this study, we investigated the potential efficiency Ticagrelor post-treatment on motor defects in a 3-nitropropionic acid (3-NP)-induced HD-like model. Symptomatic HD rats were daily treated for a week with Ticagrelor, the MAS receptor (MAS-R) antagonist A-779, or Ticagrelor + A-779. Ticagrelor amended body weight loss, motor function in open field and rotarod tests, and striatal histopathological alterations induced by 3-NP. On the striatal molecular level, Ticagrelor downregulated prorenin receptor mRNA expression but upregulated that of the MAS-R. Additionally, it decreased striatal contents of prorenin/renin and angiotensin II (Ang II), while increasing those of angiotensin-converting enzyme 2 and Ang-(1–7). Ticagrelor also hindered the phosphorylation/activation of the inositol trisphosphate receptor (IP3R), dynamin-related protein-1 (DRP-1), and PTEN-induced putative kinase 1 protein (PINK1) expressions. Additionally, it boosted the voltage-dependent anion channel-1 (VDAC-1) and Mitofusin-2 (Mnf-2) striatal contents. A-779 partially reverted Ticagrelor impact on all amendments except for prorenin receptor and p-IP3R. However, prorenin/renin correlated markedly with IP3R, DRP-1, and PINK1, but inversely with VDAC-1 and Mfn-2. In conclusion, Ticagrelor demonstrates promising neurotherapeutic effects in HD partially via the activation of MAS-R, inhibition of prorenin/renin/prorenin receptor, and improvement of mitochondrial homeostasis.
Repurposing of semaglutide by targeting SIRT1 and TGF‐β/Smad signaling in hepatic fbrosis
(Springer Science and Business Media Deutschland GmbH, 2025-10-20) Omnia A. Hawary; Walaa Wadie; Yasmin A. M. El‑Said; Omnia F. Hassan
The transforming growth factor-β (TGF-β)/Suppressor of Mothers against Decapentaplegic (Smad) signaling pathway plays an important role in the pathogenesis and progression of liver fibrosis. This current study was conducted to investigate the effect of semaglutide (SEMA), a glucagon-like peptide-1 (GLP-1) receptor agonist, in a mouse model of liver fibrosis. The mice received thioacetamide (TAA) (150 mg/kg, biweekly) via intraperitoneal (i.p.) injection for nine consecutive weeks to induce liver fibrosis. SEMA was administered orally once daily at a dose of 0.12 mg/kg. Administration of SEMA improved liver function as demonstrated by the reduction in the plasma levels of aminotransferases and gamma-glutamyl transpeptidase (GGT) along with the rise in serum albumin level. Moreover, SEMA mitigated the TAA-induced histopathological changes and reduced the content of α-smooth muscle actin (α-SMA). SEMA ameliorated the TAA-induced oxidative stress by mitigating the derangement in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, reducing glutathione (GSH) levels, and decreasing malondialdehyde (MDA) levels. The hepatic TGF-β/Smad signaling pathway was downregulated by SEMA treatment, while sirtuin 1 (SIRT1) content and phosphorylated AMP-activated protein kinase (p-AMPK) expression were upregulated. SEMA significantly reduced the severity of liver fibrosis induced by TAA through SIRT1 activation. And it holds promise as a therapeutic agent for liver fibrosis.
Toxin to Treatment; A Narrative Review of Botulinum Toxin Applications in Dentistry
(October University for Modern Sciences and Arts MSA , Faculty of Dentistry, 2025-10-21) Lubna Ahmad Amro; Dina Mohamed Elawady; Nada Abdelmoneim Zazou
The integration of Botulinum Toxin in treatment plans has become very essential in the field of dentistry. The purpose of this review is to examine the different numerous uses of Botulinum Toxin in the dental field. Data was obtained with keywords “Botulinum Toxin”, “Botox”,” Gummy Smile”,” “Bruxism”. A Literature search was conducted using PubMed, Scopus databases, and Google Scholar. A total of 122 published articles, including case reports, case series, observational and interventional clinical trials, and systematic reviews were included in this narrative review after reviewing the literature and including the relevant studies. Botulinum Toxin could be used as an adjunct treatment or as a treatment for; Bruxism, Facial Palsy, chronic facial pain, Excessive Gingival display, papilla reconstruction, salivary gland hypersecretion, TMJ disorders, some Maxillofacial traumas and with cancer treatments. Botulinum Toxin has given dentists a less invasive treatment modality for several conditions; however, dentists should make sure they have the full knowledge and expertise before incorporating botulinum toxin in their treatment plans.
MSA at ImageCLEF 2025 Multimodal Reasoning: Multilingual Multimodal Reasoning With Ensemble Vision-Language Models
(CEUR-WS, 2025-09-09) Seif Ahmed; Mohamed T. Younes; Abdelrahman Moustafa; Abdulrahman Allam; Hamza Moustafa
We present a robust ensemble-based system for multilingual multimodal reasoning, designed for the ImageCLEF 2025 EXAMS-V challenge. Our approach integrates Gemini 2.5 Flash for visual description, Gemini 1.5 Pro for caption refinement and consistency checks, and Gemini 2.5 Pro as a reasoner which handles final answer selection, all coordinated through carefully engineered few-shot and zero-shot prompts. We conducted an extensive ablation study, training several large language models (Gemini 2.5 Flash, Phi-4, Gemma-3, Mistral) on an English dataset and its multilingual augmented version. Additionally, we evaluated Gemini 2.5 Flash in a zero-shot setting for comparison and found it to substantially outperform the trained models. Prompt design also proved critical: enforcing concise, language-normalized formats and prohibiting explanatory text boosted model accuracy on the English validation set from 55.9% to 61.7%. On the official leaderboard, our system (Team MSA) achieved first place overall in the multilingual track with 81.4% accuracy, and led 11 out of 13 individual language tracks, with top results such as 95.07% for Croatian and 92.12% for Italian. These findings highlight that lightweight OCR–VLM ensembles, when paired with precise prompt strategies and cross-lingual augmentation, can outperform heavier end-to-end models in high-stakes, multilingual educational settings.
How TikTok's AI Algorithms are Driving Customer Engagement in the age of Social Media Marketing
(IGI Global, 2025-08-12) Ayat Ahmed Mahmoud Kamal Embabi
The current chapter investigates TikTok's AI personalization tools which revolutionize marketing approaches as they redefine digital engagement. TikTok employs machine learning alongside natural language processing and computer vision to provide hyper-personalized content based on user behaviour analysis (Zaharia et al., 2024). AI systems optimize campaign targeting efforts while increasing ROI and adapting to user preference changes in real time (Babadoğan, 2024; Gungunawat et al., 2024). Growing concerns about data privacy issues alongside algorithmic bias and manipulation exist according to recent research by Saura et al., 2024 and Sarioguz & Miser, 2024. Personalization triggers user discomfort when it becomes intrusive (Ding et al., 2024), which underscores the necessity of ethical AI governance (Vukmirović et al., 2025). Using case studies this chapter demonstrates that real- time analytics and influencer campaigns boost engagement while providing a conceptual framework to explain how AI creates stronger brand-audience relationships (Lu, 2024; Shen, 2023; Suhardi et al., 2024).