Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities
| dc.Affiliation | October University for modern sciences and Arts MSA | |
| dc.contributor.author | Laila H. Abdel-Rahman | |
| dc.contributor.author | Doaa Abou El-ezz | |
| dc.contributor.author | Abdel-Mawgoud M. Abdel-Mawgoud | |
| dc.contributor.author | Mohamed R. Shehata | |
| dc.contributor.author | Mahmoud Abd El Aleem Ali Ali El-Remaily | |
| dc.contributor.author | Mohamed AbdelHameed | |
| dc.contributor.author | Shaaban K. Mohamed | |
| dc.date.accessioned | 2026-03-30T09:24:49Z | |
| dc.date.issued | 2026-03-07 | |
| dc.description | SJR 2024 0.874 Q1 H-Index 347 Subject Area and Category: Multidisciplinary Multidisciplinary | |
| dc.description.abstract | This study presents the synthesis and comprehensive characterization of four novel metal-complexes formed from the reaction of copper(II), nickel(II), zinc(II), and vanadium(IV) salts with the bidentate ibuprofen Schiff base ligand (HL) in 1:1 metal-to-ligand ratio. The copper complex shows the highest antibacterial and cytotoxicity efficiency, in addition to a strong binding interactions with DNA. The in-vitro anti-inflammatory and anti-COVID-19 potencies of HL and its complexes were assessed, ranking them as: CuL > NiL > ZnL > VOL > HL. | |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=21100200805&tip=sid&clean=0 | |
| dc.identifier.citation | Abdel-Rahman, L. H., El-ezz, D. A., Abdel-Mawgoud, A.-M. M., Shehata, M. R., El-Remaily, M. A. E. A. A. A., Abdel-Hameed, M., & Mohamed, S. K. (2026). Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities. Scientific Reports, 16(1). https://doi.org/10.1038/s41598-026-38270-8 | |
| dc.identifier.doi | https://doi.org/10.1038/s41598-026-38270-8 | |
| dc.identifier.other | https://doi.org/10.1038/s41598-026-38270-8 | |
| dc.identifier.uri | https://repository.msa.edu.eg/handle/123456789/6686 | |
| dc.language.iso | en_US | |
| dc.publisher | Nature Research | |
| dc.relation.ispartofseries | Scientific Reports ; volume 16 , Article number: 8501 , (2026) | |
| dc.subject | Ibuprofen | |
| dc.subject | o-vanillin | |
| dc.subject | antimicrobial | |
| dc.subject | anticancer | |
| dc.subject | DNA interaction | |
| dc.subject | DFT | |
| dc.subject | Vanadium | |
| dc.subject | Copper | |
| dc.subject | Nickel | |
| dc.subject | Zinc. | |
| dc.title | Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities | |
| dc.type | Article |