MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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    MiR-200c restoration inhibits FOXP3 and metastatic spread in breast cancer: evidence from in vitro and in vivo models
    (BioMed Central Ltd, 2026-02-14) Nashwa El-Khazragy; Ahmed Alsolami; Ahmed M. Aref; Marwa N. M. Hassan; Mohamed S. Othman
    Background: Metastatic breast cancer remains a leading cause of cancer-related mortality in women, often driven by molecular pathways that promote invasion and immune evasion. MicroRNA-200c (miR-200c) is a known tumor suppressor that inhibits epithelial-mesenchymal transition (EMT), while FOXP3, a transcription factor typically associated with regulatory T cells, is aberrantly expressed in breast cancer cells and may contribute to tumor progression. This study investigates whether targeting the miR-200c/FOXP3 axis can suppress metastasis in breast cancer. Methods: Metastatic (MDA-MB-361, MDA-MB-468) and non-metastatic (MCF-7) breast cancer cell lines were transfected with miR-200c mimic or inhibitor. Cell proliferation, apoptosis, and invasion were assessed using MTT, Annexin V/PI staining, and transwell assays. FOXP3 mRNA and protein levels were quantified using qRT-PCR and immunohistochemistry. A metastatic mouse model was established via intracardiac injection of tumor cells, followed by treatment with miR-200c mimic, inhibitor, or Cisplatin. Results: MiR-200c overexpression significantly suppressed proliferation and invasion and enhanced apoptosis in metastatic cells. FOXP3 mRNA and protein expression were downregulated in mimic-treated cells and tissues, while miR-200c inhibition led to increased FOXP3 expression. In vivo, miR-200c mimic treatment reduced tumor burden and metastatic infiltration in the brain and lungs. A strong inverse correlation between miR-200c and FOXP3 was observed (r = − 0.82, p < 0.01). Conclusion: MiR-200c restoration inhibits FOXP3 and suppresses metastatic progression in breast cancer. Targeting the miR-200c/FOXP3 axis presents a novel and promising therapeutic approach for advanced breast cancer.
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    Prevalence of Different Etiologies of Excessive Gingival Display: Identifying Diagnostic Patterns
    (John Wiley and Sons Ltd, 2026-01-12) Lubna Ahmad Amro; Mahetab Mohamed Abdalwahab; Nada Zazou; Ahmed Elsayed Hamed Amr
    Objectives: This study is aimed at evaluating the prevalence of etiologies of excessive gingival display (EGD) in Egyptian females including gingival enlargement (GE), altered passive eruption (APE), incisor over‐eruption (IO), protrusion (P), vertical maxillary excess (VME), short upper lip (SUL), and hyperactive upper lip (HUL) and to identify clinical diagnostic patterns. Methods: A total of 160 participants showing EGD > 2 mm were recruited. Clinical photos, videos, and measurements of facial proportions, upper lip length, upper lip mobility, incisor display upon rest, clinical crown dimensions, occlusal plane discrepancies, probing depth, transgingival probing, and keratinized gingiva were recorded and analyzed. Results: Mean age was (27.62 ± 6.21) years. Overall prevalence of EGD 13.3% among them 55.8% EGD caused by single etiology, 44.3% EGD caused by multiple etiologies. 29.4% APE, 16.3% SUL + APE, 10% VME + APE, 8.8% VME, 6.3% HUL, 5% Incisor over‐eruption, 3.8% GE, 3.8% SUL + GE, 3.1% VME + HUL, 2.5% SUL, 2.5% APE + HUL, 1.3% VME + GE, and 1.3% VME+SUL+APE... Conclusions: APE both alone and combined with another etiology is the most prevalent cause of EGD and the most common diagnostic pattern is APE + SUL among Egyptian females. Single‐factor and multifactorial EGD showed no significant difference in prevalence (p = 0.115), suggesting a similar likelihood of occurrence. Clinical Relevance: This study aimed to provide the clinician with a step‐by‐step guide for EGD comprehensive diagnosis, highlight the differences in prevalent etiologies between different populations and identify diagnostic patterns.
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    Artificial Intelligence Translation of Arabic Funny Comics by ChatGPT and Transmonkey
    (CDELT, 2025-10-02) Safa ’a A. Ahmed; Rawan Mohamed Elhamzawy
    The translation of funny comics from Arabic into English is a complicated task because of the interaction between linguistic, cultural, and visual factors. The present study aims to investigate this issue. Sample data is collected from some chosen Arabic funny comics and their machine translations by ChatGPT and Transmonkey The approach is based on content analysis and a comparison of textual and visual elements, to explore the way the linguistic, cultural and visual content is transferred. It delves into the theory of acculturation by John Berry (1997) that contributes to the explanation of linguistic and cultural adaptation in such funny comics. It concludes that Artificial Intelligence may fail to translate both the message and the visual content in Arabic comics and that translation depended on cultural strategies, specifically integration, in order to make the message and the funny comic effect as accessible as possible to the English target readers.
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    Dose-dependent effects of camel milk on immune function and metabolic health in weaning rats
    (Nature Research, 2026-02-05) Alyaa Farid; Mahy Mohamed; Maryam Amr; Gehan Safwat
    Breastfeeding cannot fulfill an infant’s nutritional needs beyond six months, necessitating theintroduction of alternative milk sources. Camel milk has emerged as a promising candidate due to itsrich profile of nutrients and immunomodulatory properties. This study evaluated the dose-dependenteffects of camel milk on general health and immune response in post-weaning rats, with particularattention to sex-specific differences. Male and female rats were divided into: control (GI), and fourtreatment groups receiving 2.4 mL (GII), 3.4 mL (GIII), 4.4 mL (GIV), or 5.4 mL (GV) of camel milkdaily for six weeks. Serum biochemical parameters, including lipid profile, liver and kidney functionmarkers, and immunological responses were assessed before and after immunization with sheep redblood cells. While higher doses (4.4–5.4 mL) significantly enhanced immune response and bone health,they concurrently elevated liver and kidney function parameters. The 3.4 mL dose balanced benefits,showing significant immune enhancement and bone health improvement without adverse metaboliceffects. These findings demonstrated that camel milk (3.4 mL for rats/473 mL for infants) safelyenhanced immune function, while higher doses risk metabolic stress. The results supported camelmilk’s potential as a nutritional supplement during weaning but emphasized the importance of dose regulation.
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    Therapeutic potential of mesenchymal stem cells in cisplatin-induced acute kidney injury via ASK-1/ TXNIP pathway modulation
    (Termedia Publishing House Ltd., 2025-01-04) Amal Abdelaziz; Radwa Y. Mekky; Omnia F. Hassan; Sherine M. Ibrahim
    Introduction: Acute kidney injury (AKI) is a diverse set of illnesses characterized by a rapid decline in kidney function. However, kidney transplantation and supportive therapies still have many limitations in slowing the progression of kidney diseases. The effective role of mesenchymal stem cells (MSCs) in cell-based therapy and endogenous repair for AKI is still under investigation. Several studies have indicated that MSCs could both repair and ameliorate kidney injury due to its anti-inflammatory and anti-apoptotic potential effects. The aim of this study was to evaluate the effects of MSCs on renal cell apoptosis in cisplatin-induced AKI rats and examine the underlying molecular mechanisms. Material and methods: Characteristics and homing of MSCs to kidney tissues were identified by flow cytometry and differentiation capability. After AKI induction by cisplatin injection in sixteen albino rats, the AKI rats were further subdivided into three subgroups. The first subgroup served as a positive control and the second one received 2 mg/kg furosemide (FUR), which served as a standard drug. The third subgroup received a single dose of 5 × 106 MSCs via tail vein injection once a week for 2 consecutive weeks. AKI-related biochemical parameters were assayed at 2 weeks after MSC treatment. Kidney histological changes were also evaluated. Moreover, apoptosis of kidney cells and expression of apoptosis-related proteins were assessed by western blot. Results: Compared with AKI rats, rats treated with MSCs showed suppressed serum levels of creatinine and blood urea nitrogen. MSC treatment alleviated the pathological abnormalities in the kidneys of AKI rats as shown by H&E staining. Furthermore, MSC treatment suppressed apoptosis of kidney cells in AKI rats via downregulation of apoptotic proteins: thioredoxin-interacting protein (TXNIP) and apoptosis signal-regulating kinase 1 (ASK1). Most importantly, MSC treatment promoted the expression of vascular endothelial growth factor (VEGF) in the kidneys of AKI rats. Conclusions: Our results suggest that MSCs could ameliorate renal injury of AKI rats via their anti-apoptotic properties. Also, the protective effects of MSCs may be mediated by their potential angiogenic effects.