MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 140
A Full content for MSA university Faculties Journals
MSA Theses 5
A digital collection of MSA University postgraduate theses, including PhD and Master’s theses, organized by academic degree and faculty.
MSA University Academic Graduation Projects 1153
A Full content for msa university Distinguished Graduation Projects Yearbook
MSA University Academic Research 3818
MSA University Campus 2
Images for MSA University " sites - building - landscape "

Recent Submissions

Accuracy of a deep learning–based model for treatment recommendation in adult patients with skeletal Class III malocclusion
(Elsevier Inc., 2026-09) Maha Swelam; Ahmed S. Fouda; Mostafa El Dawlatly; Farid Ali; Mona M. Salah Fayed
Introduction: Treatment planning for adult patients with skeletal Class III malocclusion remains challenging because of overlapping diagnostic criteria and subjective weighting of skeletal vs soft-tissue considerations. This retrospective study aimed to develop and evaluate the accuracy of a convolutional neural network (CNN)-based image classification in predicting treatment approach and supporting orthodontists in deciding between orthodontic camouflage and orthognathic surgery. Methods: Using 1826 pretreatment images of 166 adult patients with skeletal Class III malocclusion (86 camouflage and 80 surgical), a hybrid model was developed that combines both deep learning and machine learning. These images included lateral cephalometric and panoramic radiographs and 9 intraoral and extraoral photographs. Of note, 11 CNN models processed each image type to generate binary predictions that were combined into an 11-dimensional vector and classified using 7 conventional machine learning algorithms. Results: Support vector machine, multilayer perceptron, logistic regression, k-nearest neighbor, and naive Bayes showed no statistically significant difference compared with random forest (P >0.05). Decision tree exhibited statistically significant inferior performance compared with random forest (P <0.01). Significance analysis indicated that soft-tissue photographs had a higher correlation with treatment decisions than that of cephalometric radiographs, although clinical validity requires expert confirmation. Conclusions: A CNN-based ensemble model demonstrated high diagnostic accuracy for predicting camouflage vs surgical treatment in adult patients with skeletal Class III malocclusion within a single-center dataset.
Syringic Acid–Loaded Emulsomes as a Neuroprotective Delivery System: Formulation Optimization and In‑Vivo Pharmacokinetic Evaluation
(Springer Science and Business Media Deutschland GmbH, 2026-09-08) Nabila M. Sweed; Mahitab H. Elbishbishy; Sara S. Saleh; Marwa H. S. Dawoud
Syringic acid (SA) demonstrates significant anti-inflammatory, antioxidant, and neuroprotective properties. Unfortunately, its clinical applicability is limited by low solubility and low bioavailability. SA-loaded emulsomes were developed to overcome these limitations. The emulsomes were prepared using thin-film hydration method and optimized by a Central Composite Design. Three independent variables were studied: the solid lipid-to-phosphatidylcholine ratio, drug amount, and solid lipid type (trilaurin or tripalmitin). The measured responses were entrapment efficiency (EE%), particle size (PS), and zeta potential (ZP). The optimized formula exhibited an EE% of 61.92 ± 0.09%, a PS of 190.02 ± 0.13 nm, a PDI of 0.21 ± 0.07 and a ZP of -36.3 ± 0.98 mV. In-vitro release studies demonstrated a sustained release profile, with 92% of SA released over 24 h. The relative bioavailability of SA from the optimized formula was 219% compared to the unformulated drug. A physiologically based pharmacokinetic (PBPK) model was developed to predict plasma and tissue distribution. The model predicted a twofold increase in brain bioavailability, suggesting the potential for improved brain penetration and retention. These findings establish emulsomes as a promising nanoplatform for overcoming syringic acid's biopharmaceutical barriers and advancing its clinical potential.
Comparative optimization of the photocatalytic degradation of azithromycin using cerium oxide nanoparticles synthesized from chemical and natural sources: Sustainability assessment
(Elsevier B.V., 2026-09-03) Christine M. El-Maraghy; Ola M. El-Borady; Heba T. Elbalkiny
Antibiotics in wastewater have become a significant environmental concern, contributing to the emergence of antibiotic-resistant microorganisms and posing a growing threat to global public health. This study comparatively evaluated the effectiveness of biosynthesized and chemically synthesized CeO2 nanoparticles (CeO2NPs) for the degradation of azithromycin (AZI), one of the most frequently detected antibiotics in aquatic environments. The biosynthesized CeO2NPs were prepared using fresh Psidium guajava L. leaves. The response surface methodology, using Box–Behnken experimental design was employed to optimize the critical factors influencing the photodegradation of AZI; as initial concentration of AZI, agitation rate, pH, the contact time, the type and amount of CeO2NPs. The biosynthesized CeO2NPs demonstrated a remarkable removal efficiency of 98.6% at pH 7 and contact time of 5 h under lamp irradiation, significantly exceeding that of the chemically synthesized CeO2NPs. Additionally, the greenness profile of the solvents used was evaluated using the Greenness Index Tool and the nanomaterials performance and synthesis sustainability was assessed by the newly introduced Nanomaterials Assessment Tool (NAT). The recyclability and reusability of the biosynthesized nanoparticles were evaluated, demonstrating consistent efficiency and promising potential for water treatment applications. These findings demonstrate the significant potential of the biosynthesized CeO2NPs for mitigating antibiotic pollution, particularly in strategies aimed at combating bacterial resistance, while also promoting sustainable practices in nanotechnology applications.
Comparative Formulation and Evaluation of Ginger Nano-emulgel and Glucosamine Sulphate Gel for Adjunctive Periodontal Therapy
(Springer, 2026-09-01) Rana A. El-Gohary; Dina A. Osman; Hala A. Abuel Ela; Maha K.A. Khalifa; Susan Sarhan; Olfat G. Shaker
Background: Local drug delivery systems have emerged as promising adjuncts to non-surgical periodontal therapy (NSPT) by enhancing drug bioavailability within periodontal pockets. This study aimed to formulate and evaluate a ginger essential oil (GEO) nano-emulgel and compare its clinical efficacy with glucosamine sulphate (GS) gel as adjuncts to NSPT. The primary objective of this work was to evaluate the effectiveness of the local application of Ginger essential oil (GEO) nano-emulgel versus Glucosamine sulphate (GS) gel on clinical parameters of periodontitis, including the plaque index (PI), mean sulcus bleeding index (MSBI), clinical attachment level (CAL), and probing depth (PD) in adjunct to non-surgical periodontal therapy. The secondary objective is to detect the effect of both gels on Receptor activator of nuclear factor kappa B ligand (RANKL) levels in the gingival crevicular fluid (GCF). Methods: GEO nano-emulgel and GS gel were formulated and characterized for physicochemical properties, rheology, and in vitro drug release. GEO nano-emulgel was further evaluated for particle size, polydispersity index, zeta potential, and morphology. A randomized controlled clinical trial was conducted on 30 patients with periodontitis allocated to either the GEO nano-emulgel or GS gel group (n = 15 each) following scaling and root surface debridement. Clinical periodontal parameters were assessed at baseline and after 3 months, while GCF RANKL levels were measured at baseline, 1 month, and 3 months using enzyme-linked immunosorbent assay. Results: The optimized GEO nano-emulgel exhibited favorable physicochemical characteristics, sustained diffusion-controlled drug release, and pseudoplastic flow behavior. Both formulations significantly improved plaque index, mean sulcus bleeding index, probing depth, and clinical attachment level after treatment. No significant intergroup differences were observed in clinical parameters. However, GEO nano-emulgel achieved a significantly greater reduction in GCF RANKL levels than GS gel (p = 0.013). Conclusion: GEO nano-emulgel demonstrated promising adjunctive therapeutic potential for periodontitis by improving clinical outcomes and significantly reducing inflammatory RANKL levels compared with GS gel. Larger, long-term clinical trials are warranted to confirm these findings.
Effect of cupping therapy versus moderate-intensity aerobic exercise on the lipid profile in women with diabetes
(Universidad de Murcia, 2026-07-06) Moustafa Ibrahim Ahmed Elnaggar; Wessam Ali Alkholy; Alyaa Abdallah Atallah Ahmed Zaid; Mohamed Mohamed Mazen; Mai Mahmoud Abo Sabee Abo Sabee Sherif; Tarek H. Mahmoud; Entesar Hussein Zaky
This study aimed to find out the effect of wet cupping versus moderate-intensity aerobic exercise on lipid profile and blood sugar in diabetic obese women. Sixty diabetic women took part in this study; their ages ranged from 40 to 60 years, and their Body Mass Index (BMI) ranged from 30 to 34.9 kg/m2. They were randomly allocated into two groups; group A received medication and moderate aerobic exercise three times per week for eight weeks, and group B received medication and wet cupping two times at two months. Triglycerides, cholesterol, LDL cholesterol, and HDL cholesterol were measured before and after eight weeks at the end of the study. The study demonstrated a statistically significant reduction in the triglyceride levels (p<0.01). Total cholesterol (p<0.01) and LDL (p<0.05) levels decreased significantly in both groups. HDL levels increased significantly in Group A (p<0.01), whereas no significant increase was observed in Group B (p>0.05). It was that aerobic exercise was more effective than wet cupping therapy on the lipid profile in diabetic women.