MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 138
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RESEARCH & LANGUAGES CENTERS 18

Recent Submissions

Iron-based dendritic nanostructures incorporating curcumin and ibuprofen for possible multi-therapeutic applications
(Elsevier Ltd, 2026-04-01) Richard Alkabalan; Ziad Mohamed; Doaa Abou El-ezz; Badriah Saad Al-Farhan; Laila H. Abdel-Rahman; Brian D. Wagner; Amani A. Abdelghani
To create multifunctional dendritic nanostructures with antioxidant, antimicrobial, and anti-inflammatory properties, a total of nine dendrimers (D1–D9) were synthesized across three successive generations (G1–G3) with three different terminal groups: chloro, hydroxyl, and ibuprofen. Among these, the ibuprofen-terminated dendrimers across the three generations (G1-D3, G2-D6, and G3-D9) were selected for biological investigation owing to their potential therapeutic relevance. Structural confirmation was achieved for all dendrimers using 1H NMR and ATR-FTIR spectroscopy, while comprehensive physicochemical characterization was performed by SEM, CV, TGA, and fluorescence spectroscopy. SEM analysis revealed generation-dependent surface morphologies, ranging from amorphous-crystalline hybrids in G1-D3 to rough and highly crystalline domains in G3-D9, with G2-D6 exhibiting a uniform amorphous structure suitable for biological applications. TGA profiles indicated consistent three-step thermal degradation across generations, and CV demonstrated generation-dependent shifts in redox potential corresponding to the accumulation of redox-active cyclopentadienyliron centres. Among the synthesized dendrimers, the second-generation ibuprofen-functionalized dendrimer (G2-D6) emerged as the most promising therapeutic candidate. It exhibited superior DPPH radical scavenging activity (IC₅₀ = 16.25 μg/mL), surpassing free curcumin, ibuprofen, and the reference ascorbic acid, likely due to the combined effects of ibuprofen and organoiron moieties. G2-D6 also demonstrated potent antimicrobial and antifungal activity against E. coli, S. aureus, C. albicans, and A. niger, with antifungal performance against A. niger (inhibition zone: 37.0 ± 1.0 mm) exceeding that of Nystatin. Moreover, it achieved up to 96% inhibition in anti-denaturation assays, comparable to pure ibuprofen, highlighting its strong anti-inflammatory potential. These results position G2-D6 as a versatile, multifunctional nanotherapeutic with enhanced efficacy compared to its individual components and other dendrimer generations.
Carbon dioxide capture, utilization, and storage: recent approaches, challenges, and future prospects toward a carbon-free world
(Springer Science and Business Media Deutschland GmbH, 2026-02-02) Nourhan S. Sultan; Eman M. Hieba; Rewida R. Hamed; Hagar L. Mostafa; Wael M. Elshemey; A. Ismael; Heba M. Fahmy
In recent decades, numerous greenhouse gases have been released into the atmosphere, resulting in climatic changes and rising global temperatures. Various methods have been devised to reduce the emission of carbon dioxide (CO2) and appropriately address this issue. Carbon capture, use, and storage (CCUS) are currently embraced as a potential method, among several others. The current review article examines CCUS and its influence on mitigating the impact of carbon dioxide on the environment. Carbon dioxide capture and storage conditions are analyzed, and various technologies, transportation methods, and storage options are evaluated. The prerequisites and techniques for prolonged carbon dioxide sequestration are discussed, involving the insertion of supercritical carbon dioxide into subsurface geological formations. The economic feasibility of CO2 collection and utilization is evaluated, encompassing the integration of CCUS with electricity-producing infrastructures and the application of CO2 in the production of biofuel. Artificial intelligence plays a crucial role in evaluating CCUS criteria. Therefore, its growing significance is explored. Examining political policies, budgetary challenges, and incentives for CCUS is conducted within the framework of its 2050 forecast. Attention is also given to safety, environmental, cost, and economic considerations that significantly influence the capacity of CCUS initiatives to get adequate finance and garner governmental backing.
Caprolactam-rich vapor from copper leaching and pyrolysis of copper-impregnated nylon fishing net waste: Kinetics, thermodynamics and artificial neural network
(Elsevier B.V., 2026-01-29) Justas Eimontas; Samy Yousef; Nerijus Striūgas; Mohammed Ali Abdelnaby
This study aimed to extract copper and caprolactam from copper-impregnated nylon fishing net waste (CFNW) using chemical leaching and pyrolysis, respectively. Leaching was carried out using nitric acid, and the extraction parameters were then optimized until copper-free nylon fishing net waste was produced. Subsequently, the thermal decomposition characteristics of the leached CFNW (LCFNW) were investigated using thermogravimetric analyser (TGA) as an analytical pyrolysis reactor. The composition of the emitted pyrolysis vapors was determined using TG-FTIR and GC-MS techniques. Kinetic and thermodynamic models of LCFNW were constructed using various methods to study the reaction pathway and the complexities of its decomposition. Finally, an artificial neural network (ANN) was used to simulate the decomposition of LCFNW under unknown decomposition conditions. The optimized leaching process successfully dissolved over 99 % of copper. The TGA results showed that copper removal from CFNW reduces the its decomposition temperature to 490 °C and increases weight loss by up to 92 wt%. Simultaneously, GC-MS analysis revealed a significant increase in caprolactam content (96 %) in the pyrolysis vapors. However, leaching resulted in a slight increase in activation energy in the range of 193–302 kJ/mol with R2 ≥ 0.925. Furthermore, a trained ANN can be adapted as an advanced machine learning tool to monitor the decomposition of LCFNW under undefined conditions with R² = 1. Accordingly, leaching and pyrolysis process offer significant potential for extracting copper and caprolactam from CFNW and simplifying their decomposition process, contributing to the reduction of marine plastic pollution and the protection of aquatic ecosystems.
Significance of MALAT1 long non-coding RNA and miR-20a-5p in regulating epithelial mesenchymal transition in luminal breast cancer patients
(Springer Science and Business Media Deutschland GmbH, 2026-02-02) Gehad Tarek; Manar Fouda; Mohamed Omran; Gehan Safwat; Mahmoud Kamel; Abdel Hady Abdel Wahab
Background: Luminal breast cancer (LBC) is the most common subtype of breast cancer affecting women worldwide. Although luminal breast cancer typically has a better prognosis, it mostly responds poorly to neoadjuvant chemotherapy. Non-coding RNAs, especially long non-coding RNAs and microRNAs are crucial in regulating biological processes that contribute to breast cancer development. MALAT1, a long non-coding RNA, is pivotal in the progression of breast cancer. Epithelial-mesenchymal transition (EMT) is critical for cell movement during embryonic development. Clarifying this role could pave various avenues for developing innovative strategies for combating this subtype of malignancy. The present study aimed to investigate the expression profiles and clinical relevance of MALAT1 level and EMT-related miRNAs (miR-17-5p, miR-20a-5p, miR-93-5p, miR-135b-5p, and miR-146a-5p) alongside EMT markers (E-cadherin, N-cadherin, vimentin, fibronectin, twist, SNAI1, Slug, ZEB1, and ZEB2) in LBC patients. Methods: Fresh tissues were collected from fifty patients and twenty noncancerous controls. Differential expression of the markers was evaluated using qRT-PCR assay. Spearman Rho test assessed the relationship between the expression levels. Linear regression test evaluated the correlation between the parameters and various clinico-pathological features. Results: Our results revealed an overall upregulation of MALAT1 in breast cancer tissues although this increase did not reach statistical significance. Overexpression of miR-20a-5p, miR-135b, and ZEB2 was reported, whereas miR146a-5p, ZEB1 and Vimentin levels were suppressed. Correlation analysis demonstrated that miR-20a-5p was positively correlated with SNAI1, E-cadherin, N-cadherin and Slug also it was significantly associated with family history and tumor laterality. Conclusions: Our findings suggest that miR-20a-5p plays an oncogenic role in luminal breast cancer by promoting EMT, while MALAT1 may contribute to disease progression through indirect regulatory mechanisms. Finally, MALAT1 and miR-20a-5p might serve as potential therapeutic and prognostic targets in LBC.
Management of IBD through improving intestinal barrier function by a novel Lactiplantibacillus plantarum C4 strain
(Springer Science and Business Media Deutschland GmbH, 2026-01-21) Ahmed Samir; Amira Abdeldaim
Inflammatory bowel disease (IBD) is a globally wide spread chronic disease with remittent attacks. It causes many stressful symptoms which decrease the quality of life of the patients remarkably. IBD requires long term treatment due to its chronic nature. Probiotics are promising treatment approach for IBD due to its improve of the composition of the gut microbiota which have a great role in the development of colitis, in addition to its safety on the long term use in comparison to traditional treatment options. A novel promising Lactiplantibacillus strain, with superior probiotic potential, is tested for the management of colitis. Colitis was induced in different mice groups using dextran sodium sulphate. One group is treated by a commercial probiotic preparation, another group was treated with sulfasalazine and the last group was treated by the novel Lactiplantibacillus strain. Inflammation was assessed by measuring pro-inflammatory markers such as IL-6, IL1-β and TNF-α. Oxidative stress was determined by measuring, Catalase and SOD activities in addition to malondialdehyde level. The effect of Lactiplantibacillus strain on the intestinal barrier function was examined by measuring the expression levels of tight junction proteins of claudin1, occludin and zonula occludens1 in mice colon and CaCo2 cell line. The novel Lactiplantibacillus strain significantly decreased the inflammatory markers level and oxidative stress. It also strengthens the intestinal barrier by increasing the expression of tight junction proteins in colon tissue and CaCo2 cell line. The effect of the novel Lactiplantibacillus strain was comparable to sulfasalazine and over performed commercial probiotic preparation.