MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 138
A Full content for MSA university Faculties Journals
MSA University Academic Graduation Projects 1153
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MSA University Academic Research 3685
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RESEARCH & LANGUAGES CENTERS 18

Recent Submissions

Induction of ROS-mediated genomic instability, mitochondrial deploarization and p53-independent mitochondrial apoptotic cell death by bioactive glass nanoparticles in human A431 epidermoid skin cancer cells
(BioMed Central Ltd, 2026-04-02) Hanan R H Mohamed; Shahd Mosaad; Aya A. Osman; Alaa H. Elsewedy; Habiba M. Zaki; Mayada E. Borai; Gehan Safwat
Epidermoid skin cancer remains a significant clinical challenge due to the limited selectivity, systemic toxicity, and resistance associated with conventional chemotherapies. Bioactive glass nanoparticles (BGNPs), widely recognized for their regenerative capacity and excellent biocompatibility, have recently gained attention in nanomedicine. However, their anticancer potential, particularly in epidermoid skin cancer, has not yet been investigated. Therefore, the present study was conducted to systematically evaluate, for the first time, the cytotoxic effects and underlying molecular mechanisms of BGNPs in human A431 epidermoid carcinoma cells. Cancerous A431cells were treated with BGNPs across a concentration range of 7.8–1000 µg/ml, and cytotoxicity was quantified using the MTT assay, revealing a potent concentration-dependent reduction in cell viability with an IC50 value of 187.81 µg/ml. Mechanistic analyses demonstrated that A431 cell exposure to BGNPs at the IC50 concentration led to a significant increase in intracellular reactive oxygen species (ROS), as detected using the 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) assay, accompanied by severe mitochondrial membrane depolarization and dramatic genomic DNA damage, as confirmed by Rhodamine-123 staining and alkaline comet assay. Apoptosis was validated by DAPI staining and chromatin diffusion assays, which demonstrated characteristic nuclear condensation and fragmentation, along with significant increases in the proportion of apoptotic A431 cells following BGNPs treatment compared to untreated control cells. Furthermore, qRT-PCR analysis showed significant downregulation of apoptotic p53 alongside marked upregulation of anti-apoptotic Bcl-2 and mitochondrial ND3 genes, indicating disruption of mitochondrial and apoptotic regulatory pathways. Conclusion: Collectively, this study provides novel mechanistic evidence that BGNPs induce potent cytotoxicity in A431 cells through a ROS-mediated, mitochondria-dependent apoptotic pathway. Despite being limited to a single in vitro cell line, these findings highlight BGNPs as promising multifunctional anticancer candidates, warranting further in vitro studies across additional skin cancer models and normal keratinocyte cell lines alongside n vivo validation and exploration in combination therapeutic strategies.
HybridFormer: Data-Efficient Deep Learning for High-Dimensional Spatiotemporal Classification With Application to Neural Signal Processing
(Institute of Electrical and Electronics Engineers Inc., 2026-03-20) GHADA ABDELHADY; ABDULRAHMAN GHANDOURA; ABDULLAH ALAJMI; ZIAD GHAZALY
We present HybridFormer, a hybrid deep learning architecture for data-efficient multichannel spatiotemporal classification, validated on high-gamma EEG motor imagery. The key novelty is an ordered integration pipeline: spatial CNN features are compressed via 4:1 squeeze-and-excitation channel attention before the BiLSTM, and learned Q/K/V temporal self-attention operates after recurrent encoding. This differs from prior hybrids that apply attention only post-recurrence or as simple pooling. On the 128-channel High-Gamma Dataset, HybridFormer achieves 91.2 ± 2.8% within-subject and 78.5 ± 3.4% cross-subject accuracy using stratified 10-fold and leave-one-subject-out protocols, outperforming CNN-LSTM baselines by 6.7% and 5.4% (p < 0.001). Against transformer baselines—EEG-Transformer (BENDR), Transformer-LSTM, and EEG-Conformer—HybridFormer achieves 8.5%, 7.3%, and 6.1% higher accuracy with 2.3× fewer parameters (1.8M). A strict non-overlapping temporal split experiment without augmentation confirms a 5.1% advantage over the best baseline, ruling out information leakage.Cross-dataset validation across 22–128 channels shows consistent generalization. Ablation studies confirm significant contributions from each component (CNN: 8.7%, LSTM: 6.2%, attention: 4.3%). Attention maps correlate with motor cortex activation (r = 0.76, p < 0.001) and remain stable across random seeds (cosine similarity = 0.91 ± 0.03). Real-time inference (15 ms/sample) supports resource-constrained deployment.
Marginal Adaptation and Fracture Resistance of Nanozirconia and Zirconium Dioxide All Ceramic Restoration: An In Vitro Study
(John Wiley and Sons Ltd, 2026-03-26) Mustafa M. Al-Haddad; Ahmed M. Hamdy; Mohamed A. Mokhtar
Background: The importance of marginal adaptation for long-term success in all-ceramic crowns is highlighted, especially considering the mechanical strength of zirconia, although concerns about its hydrothermal aging and low-temperature degradation (LTD) persist. To overcome these challenges, researchers have developed NANOZR, a nanocomposite that outperforms traditional yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) in terms of strength and resistance to aging degradation in dental applications. Aim: To evaluate the marginal adaptation and fracture resistance of NANOZR and Y-TZP CAD/CAM restorations before and after thermomechanical aging. Methodology: The study involved fabricating crowns using two types of zirconia framework materials (NANOZR and Katana Y-TZP) on epoxy resin dies, with and without thermomechanical aging. Standard tooth preparation procedures were followed, including silicone index fabrication, chamfer preparation, and ensuring total occlusal convergence (TOC). The process included reference die fabrication, scanning, framework designing, milling, sintering, veneering, cementation, and aging using a chewing simulator and thermocycling protocol. Marginal adaptation and fracture resistance were evaluated using digital image analysis and a materials testing machine, respectively. Results: Y-TZP and NANOZR showed marginal gap differences before and after thermomechanical aging, with Y-TZP exhibiting a higher gap postaging. NANOZR demonstrated significantly higher fracture resistance compared to Y-TZP. A negative correlation was observed between fracture resistance and marginal gap, indicating that higher marginal gaps were associated with lower fracture resistance. Conclusion: NANOZR restorations have superior marginal adaptability compared to Y-TZP restorations following thermocycling.
Liver Enzymes in Non-Alcoholic Fatty Liver Diseases: Response to Pyramidal Versus Continuous Aerobic Training
(SINAPS LLC, 2025-12-20) Ali Mohamed Ali Ismail; Sallam Ali S. Sallam; Ibrahim Abdelrafea Salem; Asmaa M. Al-Emrany; Momen ELsaied ELsagher; Amira Hassan Abdelaziz; Ahmed Yasser Mostafa Marouf; Ramy Salama Draz
Purpose: The effect of choosing the type of exercise — the first-line conservative non-pharmacological therapy in managing non-alcoholic fatty liver disease (NAFLD) — on improving liver enzymes has not been fully investigated.: This was a comparative trial aimed to examine the response of liver enzymes to pyramidal progressive-intensity (interval) versus continuous moderate-intensity aerobic training in NAFLD women. Materials and Methods: Thirty-eight NAFLD women were randomized into a pyramidal training group (n=19) and a group of continuous moderate-intensity exercise (n=19). Both groups followed a reviewed 12-week low-calorie diet and received exercise training thrice weekly. Besides body mass index (BMI) and abdominal circumference (AC), NAFLD patients’ serum alanine transaminase enzyme (ALTE), alkaline phosphatase enzyme (ALPE), high-density lipoprotein (HDL), aspartate transaminase enzyme (ASTE), triglycerides (TGs), and gamma-glutamyl-transpeptidase enzyme (GGTE) were assessed before and after 12 weeks. Results: Significant improvements in all outcomes occurred after finishing both training forms. The pyramidal aerobic form produced more significant and pronounced improvements in the tested outcomes compared to the other form of exercise, moderate-intensity aerobic exercise. Conclusion: Both training forms, moderate-intensity aerobic exercise or pyramidal training, significantly improved NAFLD patients’ ALTE, BMI, ASTE, HDL, GGTE, AC, ALPE, and TGs, but the pyramidal form of exercise is more efficient than the continuous moderate-intensity form. © (2025), (SINAPS LLC). All rights reserved.
Evaluating responsive façade shading for enhancing daylighting performance in university classrooms across Egyptian regions
(Springer Nature, 2026-02-22) Manar Eltanbouly
Daylight quality and visual comfort are critical parameters in learning environments, particularly in climates with intense solar exposure. This study investigates responsive façade shading as a climate-adaptive strategy to improve indoor daylight performance in university classrooms across four Egyptian regions: West Cairo, Aswan, Alexandria, and Hurghada. A parametric simulation workflow was developed using Rhino, Grasshopper, Ladybug, Honeybee, Galapagos, and Wallacei-x to analyze annual daylight metrics (DA, UDI), visual comfort (DGP), and Quality of View (QV) under static and adaptive façade configurations. Findings demonstrate strong climatic dependence. Responsive shading consistently reduced over-lighting and lowered DGP, with the 50% opening ratio providing the most effective glare mitigation, while the 80% configuration improved daylight uniformity. Hurghada achieved the most balanced performance, combining stable DA and high QV with moderate glare levels. West Cairo maintained high DA but exhibited significant UDI instability, requiring finer modulation. Alexandria showed limited added benefit from responsiveness, and Aswan remained glare-dominated, indicating the need for additional control strategies. The study concludes that responsive shading should be deployed selectively and tailored to the climate, offering region-specific recommendations for future educational building design in Egypt.