MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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Recent Submissions

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    Electrochemical determination of Azelastine using a Calix[4]arene-doped polyaniline screen-printed sensor in pharmaceutical and biological samples
    (Elsevier B.V., 2027-01-01) Rawan S. El Meniawy; Sarah S. Saleh; Yasmin Rostom; Mona T. Ragab
    Careful choice of ion-sensing components and substrates is the primary focus when developing ion-selective electrodes to achieve maximum sensitivity, selectivity, stability and accuracy. This study aims to develop and optimize two miniaturized screen-printed solid-contact ion-selective electrodes to quantify Azelastine HCl (AZE) in various pharmaceutical preparations and complex spiked biological samples. The electrodes' optimization involved doping ion-sensing membranes with the most selective ionophore for the studied drug, followed by electro-polymerization of polyaniline (PANI) conducting polymer at screen-printed electrode. Two screen-printed electrodes were developed for AZE determination, and their electrochemical performance was evaluated following IUPAC recommendations. The optimal calix[4]arene-doped PANI-based screen-printed electrode reached a detection limit of 2.50 × 10−6 M for AZE with a dynamic response of about 3 s. It successfully quantified AZE in its pure form, pharmaceutical dosage forms, spiked aqueous humor and plasma, which demonstrates potential applicability. Its selectivity was assessed in the presence of the induced degradation products of AZE, interfering ions, and the co-formulated drug, fluticasone propionate. A comparison regarding greenness between the developed and two reported methods was established by means of Modified Green Analytical Procedure Index (Mo-GAPI) and Analytical Greenness (AGREE) assessment tools. Sustainability profile was established using NQS index, showing alignment of the study with the UN-17 SDGs.
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    Rosemary bioactive phytochemicals as a strategy for the management of age related conditions
    (Springer Nature, 2026-07-04) Shahira M. Ezzat; Rana M. Merghany; Basma Reda; Nihal M. El Mahdy; Omnia M. Ayman; Mohamed A. Salem
    Research on plant-derived bioactive metabolites has earned growing interest in pharmaceutical applications. Rosemary (Rosmarinus officinalis L., Lamiaceae family) is one of the most used aromatic food ingredients due to a plethora of specialized metabolites with beneficial health effects. Several rosemary components, including phenolic compounds (flavonoids and phenolic acids) and terpenoids (triterpenes, phenolic diterpenes, and volatile monoterpenes), have demonstrated various biological activities, such as antioxidant, anti-inflammatory, and beneficial effects against neurological, metabolic, and age-related disorders. This review critically examines the scientific evidence supporting the use of rosemary bioactives in managing both systemic age-related diseases (e.g., neurodegenerative disorders) and dermatological aging conditions (e.g., photoaging, loss of elasticity). Additionally, recent scientific evidence related to its use in skin-aging ingredients, functional foods, and applications in aromatherapy has been detailed and critically discussed, including possible bioactive metabolites and safety concerns.
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    Fracture resistance of maxillary lateral incisors: effects of fiber post dimensions, material, and surface treatment
    (BioMed Central Ltd, 2026-07-04) Maria Reslan; Dana El Ballouli; Rana Walid Tawil; Mohamed Sayed; Maha Fouad; Alaa Mohamed Naguib; Hend Ashraf AbdelHadi; Abdelrahman Mustafa El Sokkary; Esraa AbdelGhany; Abdel Rahman O. El Mekkawi; Sahar Mokhtar; Ehab A. Farghaly; Rehab Ali Farag; Mohammad Rayyan
    Background: Fiber-reinforced posts are widely used to restore endodontically treated anterior teeth, yet the relative contributions of post length, diameter, material, and surface treatment to fracture resistance in maxillary lateral incisors remain unclear. Purpose: To determine the individual and interactive effects of fiber post length, diameter, material, and surface treatment on the fracture resistance and failure modes of endodontically treated maxillary lateral incisors restored with composite cores and monolithic zirconia crowns. Methods: In a controlled laboratory study (2 × 2 × 2 × 2 design; 16 groups; n = 10/group; N = 160), extracted maxillary lateral incisors received standardized endodontic treatment, fiber post placement, composite core build-ups, and monolithic 5Y-PSZ zirconia crowns. Factors were: post length (8 vs. 12 mm), diameter (0.9 vs. 1.1 mm), post material/system (tested glass-fiber post system vs. tested quartz-fiber post system), and surface treatment (ethanol-cleaned vs. airborne-particle abrasion + silane). A uniform 2-mm ferrule, PDL simulation, and epoxy embedding were used. Specimens were thermocycled (10,000 cycles, 5–55 °C) and loaded at 135° to the long axis with a 3-mm indenter until failure; maximum load (N) and failure mode (repairable vs. non-repairable) were recorded. Data were analyzed with fixed-effects factorial ANOVA (Tukey post hoc) and χ² tests (α = 0.05). Results: Mean fracture load ranged from 655 ± 62 N to 971 ± 65 N. Main effects were additive: 12-mm length (+ 86.9 N), 1.1-mm diameter (+ 76.7 N), the tested quartz-fiber post system (+ 55.0 N) and abrasion+silane (+ 36.3 N) increased load (all P ≤ .010), with no interactions (all P ≥ .075). Higher-strength configurations showed fewer catastrophic root fractures. Conclusions: Within the tested, anatomy-preserving ranges, longer and slightly 1.1 mm diameter posts, the tested quartz-fiber post system and abrasion-plus-silane conditioning can be combined to improve fracture resistance in restored maxillary lateral incisors, supporting strategies that maximise bonding while preserving dentine. Limitation/future work: As an in vitro static test with thermal ageing only, cyclic fatigue and long-term interface degradation remain uncertain and should be evaluated in fatigue models and clinical trials.
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    Epstein-Barr Virus MicroRNAs as Key Regulators of Lymphoma Pathogenesis: Immune Evasion Mechanisms and Therapeutic Opportunities
    (John Wiley and Sons Inc, 2026-06-28) Rasha Abu-Khudir; Ahmed S. Doghish; Hend H. Mohamed; Nehal I. Rizk; Haidy Adel Fahmy; Salma Zaki Fayez; Yara Ashraf; Ayatallah Elgohary; Hager Nasser Selim; Moustafa Mahmoud Abdelaziz; Osama A. Mohammed; Sherif S. Abdel Mageed; Rabab S. Hamad; Reda M. Mansour
    The ubiquitous human gamma-herpesvirus Epstein–Barr virus (EBV) infects over 90% of adults globally and was the first human virus identified with oncogenic potential. EBV enters a lifelong persistence in the host via a finely regulated life-cycle comprising primary infection, latency and lytic reactivation. Within infected B-cells and epithelial cells, EBV encodes a distinct repertoire of microRNAs (miRNAs), primarily from the BART (BamHI A rightward transcript) and BHRF1 (BamHI H rightward open reading frame) clusters, which play pivotal roles in modulating both viral and host gene expression. These viral miRNAs contribute to key oncogenic processes: by dampening apoptotic responses (e.g., via targeting PUMA, Bim, and PTEN), promoting proliferation of latently-infected B-cells, inhibiting host immune responses (e.g., via down-regulation of CXCL-11 by miR-BHRF1-3), and promoting epithelial-mesenchymal transition (EMT) and metastasis through modulation of E-cadherin and other adhesion molecules. In human lymphomas, such as Burkitt lymphoma, Hodgkin lymphoma, and EBV-positive diffuse large B-cell lymphoma, the interplay of latent viral gene expression, miRNA-mediated regulatory networks, and host microenvironmental factors underlies malignant transformation and disease progression. Emerging evidence also supports the utility of EBV-encoded miRNAs as diagnostic and prognostic biomarkers in EBV-associated cancers. Importantly, therapeutic strategies aimed at interrupting viral miRNA function, restoring host tumor-suppressor pathways, and re-sensitizing tumor cells to immune surveillance hold promise. This review synthesizes current mechanistic insights into EBV-encoded miRNAs in oncogenesis, elaborates on their roles in lymphoma pathogenesis, and evaluates the translational potential of miRNA-targeted therapies in EBV-associated malignancies.
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    Framing Inclusive Heritage Urbanism Reconfiguring Publicness in Mosque-Centered Precincts in Historic Cairo
    (Publisher Mansoura University, Faculty of Engineering, 2026-06-12) Ghada S. Ghazala
    Mosque-centered precincts in historical cities face a continuous tension between touristic-led redevelopments, security management policies and urban life of commons. Recently in Historic Cairo state-led interventions occur in major mosque-centered settings with upgrading intent by enhancing visual order, crowd control and visitors’ experience, yet socio-spatial inclusivity stayed insufficiently incorporated in those implications. This study discourses this gap by initiating the Heritage Socio-spatial Inclusivity Framework (HSIF) to assess inclusivity across major mosque-centered realms – AL-Hussein Mosque & Al-Sayida Zeinab Mosque precincts . HSIF synthesized urban design & heritage conservation concepts through indicators covering aspects like communal livability, users experience, governance & heritage sustainability. The study aimed to propose context-sensitive guidelines that balance tourism pressures, governance and locals’ rights to urban heritage, through operationalizing HSIF as a diagnostic tool afore prescriptive model. Empirically; the study adopted a triangulated methodology of analysis by integrating users’ surveys, mapped on-site observations & historical precedence of urban morphological evolutions. The outcomes demonstrated an operational imbalance; as the state-led interventions helped enhancing the precincts’ vitality, temporal inclusivity, visual and spatial experience yet a vivid weakness in participatory governance, access equity and heritage incorporation in everyday life was witnessed. These results exhibited that inclusivity in rich-heritage precincts exists yet reshaped in a form of consumption-oriented publicness marginalizing commons needs and authenticity. Therefore, the study proposed three clusters of context-sensitive guidelines and their implementations each address a weakness while strategically leveraging high performing indicators for inclusive outcomes; paving the road for a sustaining users’ sense of inclusivity in rich-heritage precincts.