MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 141
A Full content for MSA university Faculties Journals
MSA Theses 5
A digital collection of MSA University postgraduate theses, including PhD and Master’s theses, organized by academic degree and faculty.
MSA University Academic Graduation Projects 1153
A Full content for msa university Distinguished Graduation Projects Yearbook
MSA University Academic Research 3829
MSA University Campus 2
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Recent Submissions

The WHO‑ISoP Pharmacovigilance Curriculum: 2026 Update
(Springer Nature, 2026-09-20) Jürgen Beckmann; Marco Tuccori; Priya Bahri; Francesco Salvo; Mónica Tarapués; Manal M. Younus; Hussain Al Ramimmy; Mayada Alkhakany; Thamir Alshammari; Beate Aurich; Nicole Baker; Madhava Balakrishnan; Ghita Benabdallah; Pernette Bourdillon Esteve; Ian Boyd; Siva Kumar Buddha; Gianmario Candore; Emiliano Cappello; Angela Caro‑Rojas; Rebecca Chandler; Jerin Jose Cherian; Karen Cohen; Salvatore Crisafulli; Shelley Deeks; Jean‑Christophe Delumeau; Moin Don; Joan Dsouza; Ernest D. Dzidzornu; Brian D. Edwards; I. Ralph Edwards; Jefman Efendi Marzuki HY; Albert Figueras; Mohammed I. Fouda; Ayako Fukushima; Giovanni Furlan; Georgy Genov; Gloria Giraldo; Michael Gold; Tarek Hammad; Kenneth Hartigan‑Go; Maria Teresa Herdeiro; Richard Hill; Noha Iessa; Katarina Ilic; Sujeet Jain; EunMi Kim; Larissa Kopp; Veronique Kugener; Smaragda Lamprianou; Navinisha Lee; Marie Lindquist; Michaela Lucas; Viola Macolic Sarinic; Ishak Mansi; Ushma C. Mehta; Johanna C. Meyer; Joseph Mitchell; Maryam Naeem; Comfort Ogar; Ladi Owolabi; Jayesh Pandit; Lembit Rägo; Emanuel Raschi; Hadir Rostom; Mulugeta Russom; George T. Sabblah; Maribel Salas; Souad Skalli; Fumihito Takanashi; Michael Tatley; Gianluca Trifro; Claudia Vaca; Florence van Hunsel; Eugène van Puijenbroek; Jessica Liliana Vargas‑Neri; Ryan J. Walker; Xinyu Weng; Ian C. K. Wong; Qun‑Ying Yue; Li Zhang; Omar Aimer; Shanthi N. Pal
This article presents a pharmacovigilance (PV) curriculum which was jointly developed by the World Health Organization (WHO) and the International Society of Pharmacovigilance (ISoP). It is an expanded update of a PV curriculum which WHO and ISoP developed in 2014 and responds to major scientific, technological, regulatory, social and public health developments that have reshaped PV over the last 12 years. Topics such as advanced therapies, global health emergencies, antimicrobial resistance, digital health, artificial intelligence, real-world evidence, medical device safety, the environmental impact of medicines, risk communication and patient engagement are addressed. The curriculum was developed through an international collaboration involving 82 contributors from different regions and professional backgrounds. The original three-level hierarchical structure was retained, with each chapter divided into four sections and each section into five or six subsections. The number of chapters increased from 15 to 26, the number of practical tasks from 40 to 125 and the number of references from 260 to 469. Practical tasks and references are provided as Electronic Supplementary Materials. The curriculum provides a comprehensive and structured inventory of contemporary PV and thus represents a reference that lecturers and institutions can use to develop context-specific training programmes. Its structure provides conceptual clarity while allowing adaptation to different settings, learners’ roles and prior knowledge, local priorities, available time and resources. It is not intended to prescribe a single standardised course. Instead, it supports the development of introductory, advanced, comprehensive or topic-specific PV education programmes. The update reflects a shared commitment of the WHO and the ISoP to strengthening PV education and capacity across regulatory, academic, healthcare, public health and industrial settings in accordance with the recommendation of the 2026 World Health Assembly to strengthen PV.
IFRS adoption and the value relevance of accounting information: A panel data analysis of Egypt's emerging capital market
(Growing Science, 2026-06-11) Gihan M. Ali; Mohamed S. El-deeb; Mohammad Zaid Alaskar
This study examines the impact of mandatory International Financial Reporting Standards (IFRS) adoption on the value relevance of accounting information in Egypt's emerging capital market. Using a panel dataset of 631 firm-year observations from non-financial companies listed on the Egyptian Stock Exchange during 2012–2024, the study investigates the association between stock prices and two key accounting measures, earnings per share (EPS) and book value per share (BVS), before and after the mandatory adoption of IFRS in 2016. The empirical analysis employs price-level valuation models, firm fixed-effects panel regressions with interaction terms, and robustness tests incorporating macroeconomic controls and year fixed effects. The findings reveal a significant structural change in the relationship between accounting information and market values following IFRS adoption. Specifically, the interaction between book value and IFRS adoption is positive and highly significant, indicating that IFRS implementation enhances the value relevance of balance-sheet information. In contrast, the interaction between earnings and IFRS adoption is statistically insignificant, suggesting limited improvement in the contemporaneous informativeness of earnings. Additional analyses show that value relevance varies across firm characteristics, with stronger effects observed among profit-making firms, Big4-audited firms, and larger companies. Overall, the results suggest that IFRS adoption improves the usefulness of financial reporting for equity valuation primarily through enhanced balance-sheet information. The study contributes new evidence from an emerging capital market and offers insights for investors, regulators, auditors, and policymakers seeking to improve financial reporting quality and market transparency.
Driving logistics and supply chain agility through supply chain digital transformation strategy implementation with the moderating role of pharmaceutical supply chains internationalization
(October University for Modern Sciences and Arts MSA , Faculty of Management Sciences, 2026-08) Heba Mohamed Adel; Salma Badawi Fathi; Muhammad Salah Nafea; Safwat Adel El-Sharkawy
The purpose of this research paper is to study the impact of implementing supply chain digital transformation strategy (SCDTSI) on fostering the logistics and supply chain agility (LSCA). It investigates the moderating effect of logistics and supply chain internationalization (LSCI) on the SCDTSI-LSCA relationship across the global pharmaceutical supply chains in Egypt. After conducting a bibliometric thematic analysis, the authors detected and bridged theoretically three active literature research themes on logistics and supply chain digital transformation, agility, and internationalization. A research model was generated and tested empirically using 250 questionnaires answered by logistics and supply chain managers at 50 international, digital, and agile pharmaceutical supply chains operating in Egypt and globally. Quantitative data were analyzed using structural equation modeling by SmartPLS-v4. Results indicated that SCDTSI has a significant positive impact on LSCA, and LSCI was found to be a significant moderator in the SCDTSI-LSCA relationship. Adopting a mixed methods approach, the authors started with exploratory then explanatory qualitative interviews with logistics and supply chain experts to obtain a comprehensive analysis of this technologically-evolving industry. The authors contributed graphically by illustrating a supply chain map of these internationally-oriented digitally-transformed agile pharmaceutical networks in Egypt. This study presented practical and social implications to logistics and supply chain professionals and policy makers on implementing supply chain digital transformation strategies with the aid of creating global partnerships and strategic alliances to reinforce a digitally-driven logistics and supply chain agility within this vital pharmaceutical industry, which will then have an ecofriendly contribution to the society.
Comparative genomic and phenotypic biosafety assessment of plant-associated Klebsiella pneumoniae species complex strains isolated from faba bean root nodules
(Elsevier GmbH, 2026-09-18) Sameh H. Youseif; Fayrouz H. Abd El-Megeed; May S. Soliman; Monerah S.M. Alqahtani; Jawaher I. Alahadeb; Amr Ageez; Akram H. Mohamed; Amani A. El-Kholy
Plant-associated members of the Klebsiella pneumoniae species complex (KpSC) may harbor genomic traits of potential agricultural relevance while also carrying resistance- and virulence-associated determinants of biosafety concern. Here, whole-genome sequencing and comparative genomic analyses were used to characterize nine KpSC strains isolated from Vicia faba root nodules, comprising three Klebsiella quasipneumoniae and six Klebsiella variicola isolates. Genome-based taxonomic analysis identified four sequence types (ST-355, ST-3956, ST-4200, and ST-4574), with phylogenomic analysis indicating that genomic relatedness was more strongly associated with sequence type than isolation source. Comparative analyses revealed lineage-associated differences in resistance- and virulence-associated genomic profiles, while multidrug non-susceptibility was phenotypically observed in K. quasipneumoniae NGB-FR79 and K. variicola NGB-FR73 and NGB-FR75. The genomes also carried genes putatively associated with agriculturally relevant traits, including nitrogen fixation, phosphorus metabolism, iron acquisition, auxin-associated pathways, and adaptation to abiotic stresses. Phenotypic assays further evaluated tolerance to salt and elevated temperature. Collectively, these findings demonstrate that nodule-associated KpSC strains combine putative plant-beneficial genomic traits with resistance- and virulence-associated determinants, emphasizing the need for strain-level genomic and phenotypic biosafety assessment before consideration for agricultural applications.
Pioglitazone protects against thioacetamide-induced liver fibrosis via AMPK-mediated inhibition of the TGF-β/Smad fibrotic cascade
(Springer Science and Business Media Deutschland GmbH, 2026-09-15) Omnia A. Hawary; Walaa Wadie; Yasmin A. M. El-Said; Omnia F. Hassan
Hepatic fibrosis is a progressive liver disorder driven largely by inflammation and oxidative stress. AMP-activated protein kinase (AMPK) plays a pivotal role in regulating hepatic fibrogenesis and represents a promising therapeutic target. Therefore, this study aimed to investigate the hepatoprotective effects of pioglitazone (PIO) and to evaluate whether AMPK activation contributes to its protective actions against thioacetamide (TAA)-induced hepatic injury and fibrosis. Liver injury was induced by intraperitoneal administration of TAA (150 mg/kg, twice weekly) for 9 weeks. During the last 3 weeks, mice received PIO (3 mg/kg/day, orally). Hepatic injury and fibrosis were assessed using biochemical, histopathological, and molecular analyses. PIO treatment significantly attenuated TAA-induced hepatic injury and fibrosis, as demonstrated by improved liver histology, reduced plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels and gamma-glutamyl transferase (GGT) activity, restoration of plasma albumin, and decreased α-smooth muscle actin (α-SMA) expression. These beneficial effects were associated with increased hepatic p-AMPK expression and reduced oxidative stress, evidenced by decreased malondialdehyde (MDA) and nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) levels and restoration of reduced glutathione (GSH) content, as well as suppression of the transforming growth factor-β (TGF-β)/suppressor of mothers against decapentaplegic (Smad) signaling pathway. PIO mitigates TAA-induced hepatic fibrosis, potentially through AMPK activation and subsequent suppression of the TGF-β/Smad signaling pathway, highlighting its potential as a promising antifibrotic agent.