MSA Repository "MSAR"
MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.
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Recent Submissions
Cinnamic acid Attenuates Cisplatin-Induced Hepatotoxicity and Nephrotoxicity
(National Academy of science, 2016-01-06) Amany A. Tohamy; Ahmed M. Aref; Ahmed E. Abdel Moneim; Romissaa H. Sayed
We investigated the effects of cinnamic acid (CA, 20 mg/kg body weight) on
cisplatin (CP)-induced hepto and nephrotoxicity in mice. CP (5 mg/kg bwt) was
injected intraperitoneally and CA was given by gastric gavage for 5 days pre- and
post-CP injection. After 5 days of CP injection, CP-induced injuries of the hepatic
and renal tissues which were evidenced (i) histopathological damage of the hepatic
and renal tissues, (ii) as increases in liver and kidney function parameters, (iii) as
increases in lipid peroxidation and nitric oxide, and (iv) as decrease in glutathione
content. In contrast, the oral administration of CA concurrently to CP intoxicated
mice brought back lipid peroxidation, nitric oxide, glutathione levels to near
normalcy. Moreover, the histological observations evidenced that CA effectively
rescues the liver and kidney from CP mediated oxidative damage. Therefore,
cinnamic acid can be considered a potential candidate for protection of hepato-and
nephrotoxicity induced by cisplatin.
Therapeutic Effect of Melatonin and/or Adipose-Derived Mesenchymal Stem Cells Against Doxorubicin-Induced Renal Toxicity in Wister Rats
(Institute of Advanced Studies, 2024-07-22) Romisaa Hussein Sayed; Emad M. El Zayat; Sherein S. Abdelgayed3; Jehane I. Eid; Mohamed Hosney
Doxorubicin (DOX) is highly effective against cancer, but its use is limited due to significant toxicity, particularly in the liver and kidneys. This toxicity is primarily caused by oxidative stress, which results in biochemical, histological, and genetic abnormalities, and disrupts the body's antioxidant defenses. Adipose-derived mesenchymal stem cells (ADMSCs) show promise in cell therapy applications against DOX toxicity Similarly, melatonin supplementation has demonstrated therapeutic potential in mitigating DOX-induced liver and kidney damage by reducing oxidative stress. Understanding and harnessing these therapeutic effects could lead to improved treatments for DOXinduced organ damage. Aims: This study focused on evaluating how melatonin and adipose-derived mesenchymal stem cells (ADMSCs) could mitigate renal toxicity induced by doxorubicin (DOX), a potent anthracycline chemotherapeutic drug known for its severe side effects. The research aimed to explore whether the antioxidant properties of melatonin and the regenerative capabilities of ADMSCs could synergistically alleviate the adverse effects of DOX on renal function in Wistar rats. Methods: The study included two main groups: a control group receiving saline and a DOX group receiving six doses of doxorubicin to induce renal toxicity. Subsequently, rats from both groups were assigned to receive treatments of saline, ADMSCs, melatonin, or a combination of ADMSCs and melatonin. Rats were euthanized at different time points post-treatment, and blood and kidney tissue samples were collected. The analysis included assessment of oxidative stress biomarkers, DNA damage, gene expression profiles, histopathological changes, and cell homing in the kidney tissues. Results: DOX induces oxidative stress, inflammation, and genotoxicity in kidneys while reducing antioxidant enzyme activity. Melatonin and/or ADMSC treatments effectively mitigate these effects by decreasing oxidative stress, inflammation, and DNA damage. The protective mechanisms involve modulation of apoptosis pathways, evidenced by changes in p53 and Bcl2 expression levels, as well as assessment of double-strand breaks using the neutral comet assay, and also the improvement of the inflammatory markers IL-6 & IL- 10 evidenced by the histopathological results. Conclusion: Melatonin and ADMSCs demonstrate protective effects against DOX-induced renal toxicity, potentially enhancing chemotherapy safety by reducing renal damage. The synergistic benefits of combining melatonin and ADMSC therapy in improving chemotherapy tolerability warrant further investigation in preclinical models to optimize treatment strategies and validate efficacy before clinical application.
Nanoparticles Modified Solid-Contact Potentiometric Sensor for Selective Nanomolar Citicoline Determination
(Institute of Physics, 2025-04-08) Passant M. Medhat; Heba-Alla H. Abd-ElSalam; Manal Mohamed Fouad; Amr M. Mahmoud; Hany H. Monir; Nermine S. Ghoniem
Highlights Citicoline sodium is administered by post-COVID-19 patients for the treatment of brain fog. Cobalt oxide nanoparticles, and copper nanoparticles modified glassy carbon potentiometric sensors were fabricated to detect Citicoline Sodium selectively. Cobalt oxide and copper nanoparticles were characterized using TEM, FTIR, and XRD. Determination of Citicoline sodium in its pharmaceutical dosage form and spiked human plasma. The proposed method was assessed for greenness using GAPI and AGREE greenness assessment tools and Whiteness assessment using RGB-12 proving its environmental safety. © 2025 The Electrochemical Society (“ECS”). Published on behalf of ECS by IOP Publishing Limited. All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Novel strategies for vancomycin-resistant Enterococcus faecalis bioflm control: bacteriophage (vB_EfaS_ZC1), propolis, and their combined efects in an ex vivo endodontic model
(BioMed Central Ltd, 2025-04-10) Toka A. Hakim; Bishoy Maher Zaki; Dalia A. Mohamed; Bob Blasdel; Mohamed A. Gad; Mohamed S. Fayez; Ayman El‑Shibiny
Background Endodontic treatment failures are predominantly attributed to Enterococcus faecalis (E. faecalis)
infection, a Gram-positive coccus. E. faecalis forms bioflms, resist multiple antibiotics, and can withstand endodontic
disinfection protocols. Vancomycin-resistant strains, in particular, are challenging to treat and are associated
with serious medical complications.
Methods A novel phage, vB_EfaS_ZC1, was isolated and characterized. Its lytic activity against E. faecalis was assessed
in vitro through time-killing and bioflm assays. The phage’s stability under various conditions was determined.
Genomic analysis was conducted to characterize the phage and its virulence. The phage, propolis, and their
combination were evaluated as an intracanal irrigation solution against a 4-week E. faecalis mature bioflm, using
an ex vivo infected human dentin model. The antibioflm activity was analyzed using a colony-forming unit assay, feld
emission scanning electron microscopy, and confocal laser scanning microscopy.
Results The isolated phage, vB_EfaS_ZC1, a siphovirus with prolate capsid, exhibited strong lytic activity
against Vancomycin-resistant strains. In vitro assays indicated its efectiveness in inhibiting planktonic growth
and disrupting mature bioflms. The phage remained stable under wide range of temperatures (− 80 to 60 °C),
tolerated pH levels from 4 to 11; however the phage viability signifcantly reduced after UV exposure. Genomic
analysis strongly suggests the phage’s virulence and suitability for therapeutic applications; neither lysogeny markers
nor antibiotic resistance markers were identifed. Phylogenetic analysis clustered vB_EfaS_ZC1 within the genus
Saphexavirus. The phage, both alone and in combination with propolis, demonstrated potent antibioflm efects
compared to conventional root canal irrigation.
Conclusion Phage vB_EfaS_ZC1 demonstrates a promising therapy, either individually or in combination
with propolis, for addressing challenging endodontic infections caused by E. faecalis
Development and optimization of lyophilized dry emulsion tablet for improved oral delivery of Ivermectin
(Editions de Sante, 2025-04-18) Eiman Abdalla Madawi; Hanan M. El-Laithy; Nihal Mohamed Elmahdy Elsayyad; Mutasem Rawas-Qalaji; Amjad Alhalaweh; Iman Saad Ahmed
Ivermectin (IVM) is a widely used antiparasitic agent and has been repurposed for the treatment of COVID-19.
However, its poor water solubility and low bioavailability present significant challenges, often requiring large
doses for therapeutic effectiveness. This poses a burden on patients, as they need to take multiple tablets at once,
which is both inconvenient and uncomfortable. This study aims to develop and optimize rapidly disintegrating
lyophilized dry emulsion tablets (LDET) containing IVM using a quality by design (QbD) approach to enhance its
solubility, dispersibility, wettability, and dissolution rate, thereby improving its absorption and bioavailability
following oral administration. Oil-in-water (O/W) emulsions were prepared using sweet almond oil or Miglyol
840 as the oil phase, along with stabilizers. The optimal emulsion was subsequently lyophilized to produce IVMLDET. Tablets’ characteristics were assessed in vitro for their properties including solubility, disintegration, and
dissolution, and in vivo in rabbits for their pharmacokinetic (PK) profile. Results indicated a remarkable 600-fold
increase in IVM solubility in the optimal emulsion formulation. IVM-LDET significantly enhanced the extent and
rate of dissolution compared to raw IVM and the marketed tablet, Iverzine®. Furthermore, the PK profile of IVM
from LDET showed a 30 % increase in maximum plasma concentration (Cmax) and area under the curve (AUC),
and reduced time to reach maximum concentration (tmax) by 4 h compared to Iverzine® tablets. In conclusion,
the developed IVM-LDET formulation presents a promising therapeutic alternative to conventional oral IVM
products for treating parasitic or viral infections, potentially leading to improved therapeutic outcomes and
patient compliance.