Novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activity

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohareb R.M.
dc.contributor.authorFleita D.H.
dc.contributor.authorSakka O.K.
dc.contributor.otherDepartment of Organic Chemistry
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherOctober City
dc.contributor.otherAR
dc.contributor.otherEgypt; Department of Chemistry
dc.contributor.otherFaculty of Science
dc.contributor.otherCairo University
dc.contributor.otherGiza
dc.contributor.otherAR
dc.contributor.otherEgypt; Department of Chemistry
dc.contributor.otherFaculty of Science
dc.contributor.otherAmerican University in Cairo
dc.contributor.other5th Settlement
dc.contributor.otherAR
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:32Z
dc.date.available2020-01-25T19:58:32Z
dc.date.issued2011
dc.descriptionScopus
dc.description.abstractThe reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects. � 2010 by the authors.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=26370&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.3390/molecules16010016
dc.identifier.doiPubMed ID 21187814
dc.identifier.issn14203049
dc.identifier.otherhttps://doi.org/10.3390/molecules16010016
dc.identifier.otherPubMed ID 21187814
dc.identifier.urihttps://t.ly/ge8P2
dc.language.isoEnglishen_US
dc.relation.ispartofseriesMolecules
dc.relation.ispartofseries16
dc.subject3-acetylpyridineen_US
dc.subjectAntitumor activityen_US
dc.subjectCoumarinen_US
dc.subjectHydrazide-hydrazoneen_US
dc.subjectThiopheneen_US
dc.subjectantineoplastic agenten_US
dc.subjectazideen_US
dc.subjectcoumarinen_US
dc.subjectcoumarin derivativeen_US
dc.subjecthydrazone derivativeen_US
dc.subjectpyridineen_US
dc.subjectpyridine derivativeen_US
dc.subjectthiazole derivativeen_US
dc.subjectthiophene derivativeen_US
dc.subjectarticleen_US
dc.subjectcell divisionen_US
dc.subjectchemistryen_US
dc.subjectdrug effecten_US
dc.subjectdrug screeningen_US
dc.subjecthumanen_US
dc.subjectnuclear magnetic resonance spectroscopyen_US
dc.subjecttumor cell lineen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectAzidesen_US
dc.subjectCell Divisionen_US
dc.subjectCell Line, Tumoren_US
dc.subjectCoumarinsen_US
dc.subjectDrug Screening Assays, Antitumoren_US
dc.subjectHumansen_US
dc.subjectHydrazonesen_US
dc.subjectMagnetic Resonance Spectroscopyen_US
dc.subjectPyridinesen_US
dc.subjectThiazolesen_US
dc.subjectThiophenesen_US
dc.titleNovel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activityen_US
dc.typeArticleen_US
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