Novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activity
Date
2011
Authors
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Series Info
Molecules
16
16
Scientific Journal Rankings
Abstract
The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects. � 2010 by the authors.
Description
Scopus
Keywords
3-acetylpyridine, Antitumor activity, Coumarin, Hydrazide-hydrazone, Thiophene, antineoplastic agent, azide, coumarin, coumarin derivative, hydrazone derivative, pyridine, pyridine derivative, thiazole derivative, thiophene derivative, article, cell division, chemistry, drug effect, drug screening, human, nuclear magnetic resonance spectroscopy, tumor cell line, Antineoplastic Agents, Azides, Cell Division, Cell Line, Tumor, Coumarins, Drug Screening Assays, Antitumor, Humans, Hydrazones, Magnetic Resonance Spectroscopy, Pyridines, Thiazoles, Thiophenes