Phytochemical and biological activities of two asteraceae plants senecio vulgaris and pluchea dioscoridis L.

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorHamed M.M.
dc.contributor.authorAbd El-Mobdy M.A.
dc.contributor.authorKamel M.T.
dc.contributor.authorMohamed H.I.
dc.contributor.authorBayoumi A.E.
dc.contributor.otherMedicinal Chemistry Department
dc.contributor.otherTheodor Bilharz Research Institute
dc.contributor.otherGiza
dc.contributor.otherEgypt; Faculty of Biotechnology
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherEgypt; Biological and Geological Sciences Department
dc.contributor.otherFaculty of Education
dc.contributor.otherAin Shams University
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:34Z
dc.date.available2020-01-09T20:40:34Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractIdentifying ornamental plants as new natural anticancer sources is always of great effective for the ornamental and horticultural industries. The investigator for Senecio vulgaris were identified by GC-MS to give a total of 14 sesquiterpenoids, represents 98.53% of the total oil, while Pluchea dioscoridis L. shows the standardization of 30 compounds essential oil represents 91.28% of the total oil. Senecio vulgaris essential oil showed a high brine shrimp lethality with LC50 value of 8 ?g/ml followed by Pluchea dioscoridis L with LC50 value of 24 ?g/ml. Following cytotoxic activity was screened by MTT viability test against HePG2 cell line. Inhibitory activity against Hepatocellular carcinoma cells of S. vulgaris and P. dioscoridis L essential oil extract under the experimental conditions exhibited a promising IC50 of 5.63 and 11.50 �g/ml, respectively compared to Doxorubicin as a control. The results demonstrated the potential of the two plants essential oils for cancer treatments; therefore, in the future in vivo experiments are required for further understanding of the effect of these plants on cancer cells to be useful in medicine. � 2019, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.en_US
dc.identifier.issn18278620
dc.identifier.urihttps://t.ly/pywKA
dc.language.isoEnglishen_US
dc.publisherSILAE (Italo-Latin American Society of Ethnomedicine)en_US
dc.relation.ispartofseriesPharmacologyonline
dc.relation.ispartofseries2
dc.subjectCytotoxic activityen_US
dc.subjectPluchea dioscoridis Len_US
dc.subjectSenecio vulgarisen_US
dc.subjectVolatile oilen_US
dc.subjectdoxorubicinen_US
dc.subjectessential oilen_US
dc.subjectplant extracten_US
dc.subjectPluchea dioscoridis extracten_US
dc.subjectSenecio vulgaris extracten_US
dc.subjectsesquiterpenoiden_US
dc.subjectunclassified drugen_US
dc.subjectanimal experimenten_US
dc.subjectArtemiaen_US
dc.subjectArticleen_US
dc.subjectAsteraceaeen_US
dc.subjectbiological activityen_US
dc.subjectcell viability assayen_US
dc.subjectcontrolled studyen_US
dc.subjectcytotoxicityen_US
dc.subjectdrug identificationen_US
dc.subjectdrug screeningen_US
dc.subjectdrug structureen_US
dc.subjectHep-G2 cell lineen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectIC50en_US
dc.subjectLC50en_US
dc.subjectlethalityen_US
dc.subjectmass fragmentographyen_US
dc.subjectMTT assayen_US
dc.subjectnonhumanen_US
dc.subjectphytochemistryen_US
dc.subjectPluchea dioscoridisen_US
dc.subjectSenecio vulgarisen_US
dc.subjectstandardizationen_US
dc.titlePhytochemical and biological activities of two asteraceae plants senecio vulgaris and pluchea dioscoridis L.en_US
dc.typeArticleen_US
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