Phytochemical and biological activities of two asteraceae plants senecio vulgaris and pluchea dioscoridis L.

Abstract

Identifying ornamental plants as new natural anticancer sources is always of great effective for the ornamental and horticultural industries. The investigator for Senecio vulgaris were identified by GC-MS to give a total of 14 sesquiterpenoids, represents 98.53% of the total oil, while Pluchea dioscoridis L. shows the standardization of 30 compounds essential oil represents 91.28% of the total oil. Senecio vulgaris essential oil showed a high brine shrimp lethality with LC50 value of 8 μg/ml followed by Pluchea dioscoridis L with LC50 value of 24 μg/ml. Following cytotoxic activity was screened by MTT viability test against HePG2 cell line. Inhibitory activity against Hepatocellular carcinoma cells of S. vulgaris and P. dioscoridis L essential oil extract under the experimental conditions exhibited a promising IC50 of 5.63 and 11.50 µg/ml, respectively compared to Doxorubicin as a control. The results demonstrated the potential of the two plants essential oils for cancer treatments; therefore, in the future in vivo experiments are required for further understanding of the effect of these plants on cancer cells to be useful in medicine.