The Usage of Albedo Orange Methanol and Ethanol Extraction as Anticancer Agent

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMoenes, Yara
dc.contributor.authorNada, Ahmed
dc.contributor.authorFahmy Mohamed, Aly
dc.date.accessioned2020-02-02T09:39:25Z
dc.date.available2020-02-02T09:39:25Z
dc.date.issued2017
dc.descriptionMSA Google Scholaren_US
dc.description.abstractThe present study aimed to evaluate the anticancer activity of methanol/ ethanol Orange Albedo extracts where test extracts showed antiproliferative activity. Also, the test extract viability % were concentration, IC50 value and cell type dependent. Also, there was a significant up / down regulation of pro/ anti apoptotic genes. Also the cell cycle profile indicated cell arrest at the G2 / M phase compared with the control accompanied with apoptotic profile significantly elevated than non treated cell control (P<0.05).en_US
dc.identifier.citation1. Abeysinghe D, Li X, Sun C, Zhang W, Zhou C, et al. Bioactive compounds and antioxidant capacities in different edible tissues of Citrus fruit of four species. Food chemistry, 104(4): 1338-1344. 2007. 2. Aggarwal BB, Vijayalekshmi R, Sung B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, longterm foe. Clinical Cancer Research, 15: 425- 430. Jan.2009. 3. Ali M M, El Kader M A A. The influence of naringin on the oxidative state of rats with streptozotocin-induced acute hyperglycaemia. Zeitschrift fur Naturforschung C, 59: 726-733. 2004. 4. Ames B N, Gold L S. Animal cancer tests and cancer prevention. Journal of the National Cancer Institute. Monographs, (12): 125- 132.1991. 5. Angst E, Park J L, Moro A, et al. The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo. Pancreas, 42(2): 223. Mar.2013. 6. Annadurai T, Thomas P A, Geraldine P. Ameliorative effect of naringenin on hyperglycemia-mediated inflammation in hepatic and pancreatic tissues of Wistar rats with streptozotocin- nicotinamide-induced experimental diabetes mellitus. Free Radical Research, 47(10): 793-803. 20137. Anthracene-induced rat mammary carcinoma. The Journal of nutritional biochemistry, 25(11): 1140-1153. 2014. 8. Aoki K, Yokosuka A, Mimaki Y, et al. Nobiletin induces inhibitions of Ras activity and mitogenactivated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells. Biological and Pharmaceutical Bulletin, 36(4): 540-547. 2013. 9. Aranganathan S, Nalini N. Antiproliferative efficacy of hesperetin (Citrus Flavanoid) in 1, 2- Dimethylhydrazine-induced colon cancer. Phytotherapy Research, 27(7): 999–1005. 2013. 10. Arivazhagan L, Pillai SS. Tangeretin, a Citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7, 12-dimethylbenz (α) 11. B Gil, MJ Sanz, MC Tereniao, ML Ferrándiz, G Bustos, et al. Effects of flavonoids on Naja naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice. Life Sciences, 54(20). 1994. 12. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? The lancet, 357(9255): 539-545. 2001. 13. Bartsch H, Nair J. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbeck's Archives of Surgery, 391(5): 499-510. 2006. 14. Bast RC, Kufe DW, Pollock RE, Weichselbaum RR, Holland JF, et al. Cell Proliferation, Differentiation, and Apoptosis. BC Decker, Hamilton, 2000. 15. Belinha I, Amorim M A, Rodrigues P, et al. Quercetin Increases Oxidative Stress Resistance and Longevity in Saccharomyces cerevisiae. Journal of agricultural and food chemistry, 55(6): 2446-2451. 2007. 16. Benavente-García O, Castillo J, Marin FR, Ortuño A, Del Río JA. Uses and properties of Citrus flavonoids. Journal of Agricultural and Food Chemistry, 45(12): 4505-4515. 1997. 17. Bensaad K, Vousden KH. Savior and slayer: the two faces of p53. Nature medicine, 11(12): 1278-1279. 2005. 18. Benz C C, Campisi J, Cohen H J, et al. Meeting report: Translational Research at the Aging and Cancer Interface. Cancer research, 4560-4563. 007. 19. Bermejo A, Llosá MJ, Cano A. Analysis of bioactive compounds in seven Citrus cultivars. Food Science and Technology International: 1082013210368556. Mar.2011. 20. Birbrair A, Zhang T, Wang Z M, et al. Type-1 Pericytes Participate in Fibrous Tissue Deposition in Aged Skeletal Muscle. American Journal of Physiology-Cell Physiology, 305(11): C1098-C1113. 2013. 21. Bocco A, Cuvelier M-E, Richard H, Berset C. Antioxidant activity and phenolic composition of Citrus peel and seed extracts. Journal of Agricultural and Food Chemistry, 46(6): 2123- 2129. 1998. 22. Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutrition reviews, 56(11): 317-333. 1998. 23. Bulzomi P, Bolli A, Galluzzo P, Leone S, Acconcia F, et al. Naringenin and 17ȕ‐ estradiol coadministration prevents hormone‐ induced human cancer cell growth. IUBMB Life, 62(1): 51-60. 2009. 24. Buscemi S, Rosafio G, Arcoleo G, et al. Effects of red orange juice intake on endothelial function and inflammatory markers in adult subjects with increased cardiovascular risk, The American journal of clinical nutrition, 95(5): 1089-1095. 2012. 25. Campisi J, Aging, cellular senescence, and cancer. Annual review of physiology, 75: 685. Sep.2013. 26. Chen H J, Lin C M, Lee C Y, et al. Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells. Oncology reports, 30(2): 925-932. 2013. 27. Coussens L M, Werb Z. Inflammation and cancer. Nature, 420(6917): 860-867. 2002. 28. Crifò T, Petrone G, Lo Cicero L, et al. Short cold storage enhances the anthocyanin contents and level of transcripts related to their biosynthesis in blood oranges. Journal of agricultural and food chemistry, 60(1): 476-481. 2011. 29. Dana, R., H. L. Malech, and R. Levy. The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils. Biochem. Journal, 297: 217-223. Mar. 1994. 30. Deryugina E I, Quigley J P. Matrix metalloproteinases and tumor metastasis. Cancer and Metastasis Reviews, 25(1): 9-34.. 2006. 31. Devaraj S, Jialal I, Rockwood J, Zak D. Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity. Clinical nutrition, 30(5): 668-671.2011. 32. Dulak J, Józkowicz A. Anti-angiogenic and antiinflammatory effects of statins: relevance to anti-cancer therapy. Current Cancer Drug Targets, 5(8): 579. 2005. 33. Ekbom A, Adami H O, Helmick C, et al. Increased risk of large-bowel cancer in Crohn's disease with colonic involvement. Lancet, 336 (8711): 357-359. 1990. 34. Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C, et al. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nature Reviews Cancer, 13(11): 759-771. 2013. 35. Escobedo-Avellanedaa, Z., Serment-Morenoa, V., Valdez-Fragosoa, A., Mujica-Paza, H., & Welti-Chanesa, J. Phytochemicals and antioxidant activity of comminuted orange (Citrus sinensis L.). 36. Ferrero Miliani L, Nielsen O, Andersen P, Girardin S. Chronic inflammation: importance of NOD2 and NALP3 in interleukin‐ 1ȕ generation. Clinical & Experimental Immunology, 147(2): 227-235. 2007. 37. Folkman J, Merler E, Abernathy C, et al. Isolation of a tumor factor responsible for angiogenesis. The Journal of Experimental Medicine, 133(2): 275-288. 1971. 38. Franco C A, Liebner S, Gerhardt H. Vascular morphogenesis: a Wnt for every vessel?. Current Opinion in Genetics & Development, 19(5): 476-483. 2009. 39. Geiger, H., Pawar, S. A., Kerschen, E. J., Nattamai, K. J., Hernandez, I., Liang, H. P. H., ... & Schambach, A. (2012). Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nature medicine, 18(7), 1123-1129. 40. Getoff N, Anti-aging and aging factors in life. The role of free radicals. Radiation Physics and Chemistry, 76(10): 1577-1586. 2007. 41. Ghasemi K, Ghasemi Y, Ebrahimzadeh M A. Antioxidant activity, phenol and flavonoid contents of 13 Citrus species peels and tissues. Pak J Pharm Sci, 22(3): 277-281. 2009. 42. Ghorbani A, Nazari M, Jeddi-Tehrani M, et al. The Citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARȖ-dependent mechanism. European journal of nutrition, 51(1): 39-46. 2012. 43. Gillen C D, Walmsley R S, Prior P, et al. Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gut, 35(11): 1590-1592. 1994. 44. Goncharova E A, Ammit A J, Irani C, et al. PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells. American Journal of Physiology-Lung Cellular and Molecular Physiology, 283(2): L354-L363. 2002. 45. Gordon M S, Mendelson D S, Kato G. Tumor angiogenesis and novel antiangiogenic strategies. International Journal of Cancer, 126(8): 1777-1787. 2010. 46. Grivennikov S I, Greten F R, Karin M. Immunity, inflammation, and cancer. Cell, 140(6): 883–899. 2010. 47. Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation. cell, 144(5): 646-674. 2011. 48. Harborne J B, Williams C A. Advances in flavonoid research since 1992. Phytochemistry, 55(6): 481-504. 2000. 49. Herrmann K. Flavonols and flavones in food plants: a review. International Journal of Food Science & Technology, 11(5): 433-448. 1976. 50. Hillebrand S, Schwarz M, Winterhalter P. Characterization of anthocyanins and pyranoanthocyanins from blood orange [Citrus sinensis (L.) Osbeck] juice. Journal of Agricultural and Food Chemistry, 52(24): 7331- 7338. 2004. 51. Hirata A, Murakami Y, Shoji M, Kadoma Y, Fujisawa S. Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression. Anticancer research, 25(5): 3367-3374. 2005. 52. Ho S C, Kuo C T. Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citrus reticulatae pericarpium). Food and Chemical Toxicology, 71: 176-182. Sep.2014. 53. Ho, K. Y., Gan, T. J., & Habib, A. S. (2006). Gabapentin and postoperative pain–a systematic review of randomized controlled trials. Pain, 126(1), 91-101. 54. Horowitz R, Gentili B. Flavonoid constituents of Citrus. Citrus science and technology, 1(1): 397- 426.1997. 55. Hsiao P C, Lee W J, Yang S F, et al. Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells. Tumor Biology, 35(12): 11903-11911. 2014. 56. Ishiwa J, Sato T, Mimaki Y, et al. A Citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts. The Journal of Rheumatology, 27(1): 20-25. 2000. 57. Johnson J L, Mejia E G. Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of GSK-3ȕ/NF-κB signaling cascade. Molecular Nutrition & Food Research, 57(12): 2112-2127. 2013. 58. Journal of Food and Nutrition Research 350 59. Jung HA, Jung MJ, Kim JY, Chung HY, Choi JS. Inhibitory activity of flavonoids fromPrunus davidiana and other flavonoids on total ROS and hydroxyl radical generation. Archives of pharmacal research, 26(10): 809-815. 2003. 60. Jung UJ, Lee M-K, Park YB, Kang MA, Choi MS. Effect of Citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. The international journal of biochemistry & cell biology, 38(7): 1134-1145. 2006. 61. Kandaswami C, Perkins E, Soloniuk D S, et al. Antiproliferative effects of Citrus flavonoids on a human squamous cell carcinoma in vitro. Cancer Letters, 56(2): 147-152. 1991. 62. Kang D H. Oxidative stress, DNA damage, and breast cancer. AACN Advanced Critical Care, 13(4): 540-549. 2002. 63. Kawaii S, Tomono Y, Katase E, et al. Antiproliferative activity of flavonoids on several cancer cell lines. Bioscience Biotechnology and Biochemistry, 63(5): 896- 899. 1999. 64. Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M. Quantitation of flavonoid constituents in Citrus fruits. Journal of Agricultural and Food Chemistry, 47(9): 3565-3571. 1999. 65. Kelebek H, Canbas A, Selli S. Determination of phenolic composition and antioxidant capacity of blood orange juices obtained from cvs. Moro and Sanguinello (Citrus sinensis (L.) Osbeck) grown in Turkey. Food Chemistry, 107(4): 1710-1716. 2008. 66. Khan A R, James M N G. Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes. Protein Science, 7(4): 815- 836. 1998. 67. Klaunig J E, Xu Y, Isenberg J S, et al. The role of oxidative stress in chemical carcinogenesis. Environmental Health Perspectives, 106(Suppl 1): 289.Feb.1998. 68. Koumoutsakos P, Pivkin I, Milde F. The fluid mechanics of cancer and its therapy. Annual review of fluid mechanics, 45(1): 325. 2013. 69. Krishnaiah D, Sarbatly R, Bono A. Phytochemical antioxidants for health and medicine–A move towards nature. Biotechnol Mol Biol Rev, 1(4): 97-104. 2007. 70. Krtolica A, Campisi J, Cancer and aging: a model for the cancer promoting effects of the aging stroma. The international journal of biochemistry & cell biology, 34(11): 1401-1414. 2002. 71. Lai C S, Li S, Miyauchi Y, et al. Potent anticancer effects of Citrus peel flavonoids in human prostate xenograft tumors. Food & Function, 4(6): 944-949. 2013. 72. Lam I K, Alex D, Wang Y H, et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Molecular Nutrition & Food Research, 56(6): 945-956. 2012. 73. Lam K H, Alex D, Lam I K, et al. Nobiletin, a polymethoxylated flavonoid from Citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model. Journal of Cellular Biochemistry, 112(11): 3313-3321. 2011 74. Landolfi R, Mower RL, Steiner M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids: structure-activity relations. Biochemical pharmacology, 33(9): 1525-1530. 984. 75. Lee AC-L, Hsiao W-C, Wright DE, Chong SY, Leow SK, et al. Induction of GADD45α expression contributes to the anti-proliferative effects of polymethoxyflavones on colorectal cancer cells. Journal of Functional Foods, 5(2): 616–624. 2013. 76. Lee E J, Kim D I, Kim W J, et al. Naringin inhibits matrix metalloproteinase‐ 9 expression and AKT phosphorylation in tumor necrosis factor‐ α‐ induced vascular smooth muscle cells. Molecular Nutrition & Food Research, 53(12): 1582-1591.Dce. 2009. 77. Lee Y C, Cheng T H, Lee J S, et al. Nobiletin, a Citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells. Molecular and Cellular Biochemistry, 347(1-2): 103-115. 2011. 78. Lentini A, Forni C, Provenzano B, et al. Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. Amino acids, 32(1): 95-100. 2007. 79. Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Molecular Cancer Research, 4(4): 221-233. 2006. 80. Luo J, Kamata H, Karin M. IKK/NF-κB signaling: balancing life and death - a new approach to cancer therapy. Journal of Clinical Investigation, 115(10) : 2625-2632. 2005. 81. Manthey J A, Guthrie N. Antiproliferative activities of Citrus flavonoids against six human cancer cell lines. Journal of Agricultural and Food Chemistry, 50(21): 5837-5843. 2002. 82. Manthey JA, Guthrie N, Grohmann K. Biological properties of Citrus flavonoids pertaining to cancer and inflammation. Current Medicinal Chemistry, 8(2): 135-153. 2001. 83. Mantovani A. Cancer: inflammation by remote control. Nature, 435: 752-753. Jun. 2005. 84. Massagué J, Gupta GP. Cancer Metastasis: Building a Framework. Cell, 127(4):679-695. 2006. 85. Miyake Y, Mochizuki M, Okada M, Hiramitsu M, Morimitsu Y, et al. Isolation of antioxidative phenolic glucosides from lemon [Citrus limon] juice and their suppressive effect on the expression of blood adhesion molecules. Bioscience, Biotechnology and Biochemistry (Japan), Aug. 2007. 86. Miyake Y, Yamamoto K, Morimitsu Y, Osawa T. Isolation of C-glucosylflavone from lemon peel and antioxidative activity of flavonoid compounds in lemon fruit. Journal of agricultural and food chemistry, 45(12): 4619- 4623. 1997. 87. Miyake Y, Yamamoto K, Morimttsu y, et al. Characteristics of Antioxidative Flavonoid Glycosides in Lemon Fruit. Food Science and Technology International, Tokyo, 4(1): 48-53. 1998. 88. Miyata Y, Sato T, Imada K, et al. A Citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells. Biochemical and Biophysical Research Communications, 366(1): 168-173. 2008. 89. Murakami A, Nakamura Y, Torikai K, et al. Inhibitory effect of Citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Cancer research, 60(18): 5059-5066. 2000. 90. Nile S H, Park S W. Edible berries: bioactive components and their effect on human health. Nutrition, 30(2): 134-144. 2014. 91. Nogata Y, Sakamoto K, Shiratsuchi H, et al. Flavonoid composition of fruit tissues of Citrus species. Bioscience, biotechnology, and biochemistry, 70(1): 178-192. 2006. 92. Okuyama S, Yamamoto K, Mori H, et al. Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain. Evidence-Based Complementary and Alternative Medicine, 42: 743-767. May.2014. 93. Ortuno A, Benavente-Garcia O, Castillo J, et al. Beneficial Action of Citrus Flavonoids on Multiple Cancer-Related Biological Pathways. Current cancer drug targets, 7(8): 795-809. 2007. 94. Pandya N M, Dhalla N S, Santani D D. Angiogenesis—a new target for future therapy. Vascular Pharmacology, 44(5): 265-274. 2006. 95. Pap M, Cooper G M. Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3- Kinase/Akt Cell Survival Pathway. The Journal of Biological Chemistry, 273(32): 19929-19932. 1998. 96. Park H Y, Choi H D, Eom H, et al. Enzymatic modification enhances the protective activity of Citrus flavonoids against alcohol-induced liver disease. Food Chemistry, 139(1): 231-240. 2013. 97. Park K-I, Park H-S, Kim M-K, Hong G-E, Nagappan A, et al. Flavonoids identified from Korean Citrus aurantium L. inhibit Non-Small Cell Lung Cancer growth in vivo and in vitro. Journal of Functional Foods, 7: 287-297. Mar.2014. 98. Peterson JJ, Beecher GR, Bhagwat SA, Dwyer JT, Gebhardt SE, et al. Flavanones in grapefruit, lemons, and limes: A compilation and review of the data from the analytical literature. Journal of food composition and analysis, 19: S74-S80. Aug.2006. 99. Peterson JJ, Dwyer JT, Beecher GR, Bhagwat SA, Gebhardt SE, et al. Flavanones in oranges, tangerines (mandarins), tangors, and tangelos: a compilation and review of the data from the analytical literature. Journal of Food Composition and Analysis, 19: S66-S73. Aug.2006. 100. Philip M, Rowley DA, Schreiber H, Philip M, Rowley. DA Inflammation as a tumor promoter in cancer induction. Seminars in Cancer Biology, 14(6): 433-439. 2004. 101. Protti M, Valle F, Poli F, et al. Bioactive molecules as authenticity markers of Italian Chinotto (Citrus× myrtifolia) fruits and beverages. Journal of pharmaceutical and biomedical analysis, 104: 75-80. Feb.2015. 102. Radhika G, Sudha V, Mohan Sathya R, et al. Association of fruit and vegetable intake with cardiovascular risk factors in urban south Indians. British Journal of Nutrition, 99(02): 398-405. 2008. 103. Rapisarda P, Fanella F, Maccarone E. Reliability of analytical methods for determining anthocyanins in blood orange juices. Journal of Agricultural and Food Chemistry, 48(6): 2249- 2252. 2000. 104. Rice-Evans C A, Miller N J, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free radical biology and medicine, 20(7): 933-956.1996. 105. Rooprai HK, Kandanearatchi A, Maidment SL, Christidou M, Trillo-Pazos G, et al. Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro. Neuropathology and Applied Neurobiology, 27(1): 29-39. 2001. 106. Salthouse T A. When does age-related cognitive decline begin? Neurobiology of aging, 30(4): 507-514. 2009. 107. Sankpal U T, Pius H, Khan M, et al. Environmental factors in causing human cancers: emphasis on tumorigenesis. Tumor Biology, 33(5): 1265-1274. 2012. 108. Schaie K W. Developmental influences on adult intelligence: The Seattle longitudinal study. Oxford University Press, 2012. 109. Schetter A J, Heegaard N H H, Harris C C. Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis, 31(1): 37-49. 2010. 110. Schulte-Hermann R, Timmermann-Trosiener I, Barthel G, Bursch W. DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. Cancer research, 50(16): 5127-5135.1990. 111. Senderowicz A M. Development of cyclindependent kinase modulators as novel therapeutic approaches for hematological malignancies. Leukemia, 15(1): 1-9. 2001. 112. Seo J, Lee H S, Ryoo S, et al. Tangeretin, a Citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic 351 Journal of Food and Nutrition Research smooth muscle cells by blocking AKT activation. European journal of pharmacology, 673(1): 56-64. 2011. 113. Shakibaei M, Harikumar K B, Aggarwal B B. Resveratrol addiction: to die or not to die. Molecular nutrition & food research, 53(1): 115–128. 2009. 114. Sharma V, Shakya A, Arya G S, et al. Chemical and potenial aspects of anthocyanins--a water soluble vacuolar flavonoid pigments: a review. International Journal of Pharmaceutical Sciences Review & Research, 6(1). 2011. 115. Shi M D, Liao Y C, Shih Y W, et al. Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. Phytomedicine, 20(8): 743-752. 2013. 116. Shih Y W, Chen P S, Wu C H, et al. αChaconine-reduced metastasis involves a PI3K/Akt signaling pathway with downregulation of NF-κB in human lung adenocarcinoma A549 cells. Journal of Agricultural and Food Chemistry, 55(26): 11035-11043. 2007. 117. Shu Z, Yang B, Zhao H, Xu B, Jiao W, et al. Tangeretin exerts anti-neuroinflammatory effects via NF-κB modulation in lipopolysaccharide-stimulated microglial cells. International Immunopharmacology, 19(2): 275- 282. 2014. 118. Sosa V, Moliné T, Somoza R, Paciucci R, Kondoh H, et al. Oxidative stress and cancer: an overview. Ageing research reviews, 12(1): 376- 390.2013. 119. Sun K, Xiang L, Ishihara S, et al. Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression. Bioscience, Biotechnology, and Biochemistry, 76(4): 640- 645. 2012. 120. Tan T W, Chou Y E, Yang W H, et al. Naringin suppress chondrosarcoma migration through inhibition vascular adhesion molecule-1 expression by modulating miR-126. International Immunopharmacology, 22(1): 107- 114. 2014. 121. Toumi ML, Merzoug S, Boutefnouchet A, Tahraoui A, Ouali K, et al. Hesperidin, a natural Citrus flavanone, alleviates hyperglycaemic state and attenuates embryopathies in pregnant diabetic mice. Journal of Medicinal Plants Research, 3(11): 862-869. 2009. 122. Tripoli E, La Guardia M, Giammanco S, et al. Citrus flavonoids: Molecular structure, biological activity and nutritional properties: A review. Food chemistry, 104(2): 466-479. 2007. 123. Wang Y C, Chuang Y C, Hsu H W. The flavonoid, carotenoid and pectin content in peels of Citrus cultivated in Taiwan. Food chemistry, 106(1): 277-284. 2008. 124. Wang Y C, Chuang Y C, Ku Y H. Quantitation of bioactive compounds in Citrus fruits cultivated in Taiwan. Food chemistry, 102(4): 1163-1171. 2007. 125. Wilmsen PK, Spada DS, Salvador M. Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. Journal of agricultural and food chemistry, 53(12): 4757- 4761. 2005. 126. World Health Organization. World Cancer Report 2014 (ePUB). WHO. int. http://apps. who. int/bookorders/anglais/detart1. jsp, 2014. 127. Xi W, Fang B, Zhao Q, Jiao B, Zhou Z. Flavonoid composition and antioxidant activities of Chinese local pummelo (Citrus grandis Osbeck.) varieties. Food chemistry, 161: 230- 238. 2014. 128. Yoshida H, Watanabe W, Oomagari H, et al. Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes. The Journal of nutritional biochemistry, 24(7): 1276-1284. 2013. 129. Yoshimizu N, Otani Y, Saikawa Y, et al. Antitumour effects of nobiletin, a Citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation. Alimentary Pharmacology & Therapeutics, 20(s1): 95–101. 2004. 130. Yu J, Wang L, Walzem RL, Miller EG, Pike LM, et al. Antioxidant activity of Citrus limonoids, flavonoids, and coumarins. Journal of agricultural and food chemistry, 53(6): 2009- 2014. 2005. 131. Zallen G, Moore E E, Johnson J L, et al. New mechanisms by which secretory phospholipase A2 stimulates neutrophils to provoke the release of cytotoxic agents. Archives of Surgery, 133(11): 1229-1232. 1998. 132. Zhang Y, Dou H, Li H, et al. The Citrus flavonoid nobiletin inhibits proliferation and induces apoptosis in human pancreatic cancer cells in vitro. Food Science and Biotechnology, 23(1): 225-229. 2014. 133. Zhang Y, Sun Y, Xi W, Shen Y, Qiao L, et al. Phenolic compositions and antioxidant capacities of Chinese wild mandarin (Citrus reticulata Blanco) fruits. Food Chemistry, 145: 674-680. 2014.en_US
dc.identifier.issn2454-1362
dc.identifier.urihttps://t.ly/v8PKY
dc.language.isoenen_US
dc.publisherImperial Journal of Interdisciplinary Researchen_US
dc.relation.ispartofseriesImperial Journal of Interdisciplinary Research;Vol-3, Issue-6, 2017
dc.subjectCanceren_US
dc.subjectAlbedo orangeen_US
dc.subjectLungen_US
dc.subjectLarynxen_US
dc.subjectPro-apoptoticen_US
dc.subjectAnti-apoptoticen_US
dc.titleThe Usage of Albedo Orange Methanol and Ethanol Extraction as Anticancer Agenten_US
dc.typeArticleen_US

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