Up-regulation of Notch-1 in psoriasis: An immunohistochemical study

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAbdou A.G.
dc.contributor.authorMaraee A.H.
dc.contributor.authorSharaf A.
dc.contributor.authorElnaidany N.F.
dc.contributor.otherPathology Department
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenofiya University
dc.contributor.otherShebein Elkom
dc.contributor.otherEgypt; Dermatology and Andrology Department
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenofiya University
dc.contributor.otherShebein Elkom
dc.contributor.otherEgypt; Faculty of Pharmacy
dc.contributor.otherMSA University
dc.contributor.otherOctober City
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:27Z
dc.date.available2020-01-25T19:58:27Z
dc.date.issued2012
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractThe Notch pathway plays a key role in differentiation, proliferation, and influencing cell fate decision in multiple organisms and tissues including the epidermis and its appendages. The role of Notch-1 in psoriasis has not been widely evaluated; therefore, the current study aimed to evaluate its role in etiopathogenesis of this common skin disease. The current study used immunohistochemical technique to evaluate Notch-1 expression in 35 lesional biopsies of patients having chronic plaque psoriasis in comparison with normal skin biopsies, representing the control group. Notch-1 was expressed in the epidermis of both normal and psoriatic skins; however, the intensity was in favor of psoriatic lesion, and the nuclear form of Notch-1 was more frequently and diffusely seen in psoriasis. Exacerbation of psoriasis as assessed by the Psoriasis Area and Severity Index score was significantly associated with intense (P =.005) and nuclear form of Notch-1 expression (P =.0001). The nuclear form of Notch-1 was also correlated with female sex (P =.043). From this study, up-regulation and not down-regulation of Notch-1 may have a role in pathogenesis of psoriasis. The nuclear form is responsible for the exacerbation of symptoms, and it is the one that may disappear by the effect of psoralen and ultraviolet A radiation (PUVA) therapy. � 2012 Elsevier Inc.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=27475&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.anndiagpath.2011.09.005
dc.identifier.doiPubMed ID 22197545
dc.identifier.issn10929134
dc.identifier.otherhttps://doi.org/10.1016/j.anndiagpath.2011.09.005
dc.identifier.otherPubMed ID 22197545
dc.identifier.urihttps://t.ly/W5kPm
dc.language.isoEnglishen_US
dc.relation.ispartofseriesAnnals of Diagnostic Pathology
dc.relation.ispartofseries16
dc.subjectImmunohistochemistryen_US
dc.subjectNotch-1en_US
dc.subjectPsoriasisen_US
dc.subjectPUVAen_US
dc.subjectNotch1 receptoren_US
dc.subjectpsoralenen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectchronic diseaseen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectcorrelation analysisen_US
dc.subjectdisease exacerbationen_US
dc.subjectepidermisen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectimmunohistochemistryen_US
dc.subjectmaleen_US
dc.subjectpriority journalen_US
dc.subjectprotein expressionen_US
dc.subjectPsoriasis Severity Indexen_US
dc.subjectpsoriasis vulgarisen_US
dc.subjectPUVAen_US
dc.subjectskin biopsyen_US
dc.subjectupregulationen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectChilden_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPsoriasisen_US
dc.subjectPUVA Therapyen_US
dc.subjectReceptor, Notch1en_US
dc.subjectSkinen_US
dc.subjectUp-Regulationen_US
dc.subjectYoung Adulten_US
dc.titleUp-regulation of Notch-1 in psoriasis: An immunohistochemical studyen_US
dc.typeArticleen_US
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