Up-regulation of Notch-1 in psoriasis: An immunohistochemical study
Date
2012
Authors
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Series Info
Annals of Diagnostic Pathology
16
16
Scientific Journal Rankings
Abstract
The Notch pathway plays a key role in differentiation, proliferation, and influencing cell fate decision in multiple organisms and tissues including the epidermis and its appendages. The role of Notch-1 in psoriasis has not been widely evaluated; therefore, the current study aimed to evaluate its role in etiopathogenesis of this common skin disease. The current study used immunohistochemical technique to evaluate Notch-1 expression in 35 lesional biopsies of patients having chronic plaque psoriasis in comparison with normal skin biopsies, representing the control group. Notch-1 was expressed in the epidermis of both normal and psoriatic skins; however, the intensity was in favor of psoriatic lesion, and the nuclear form of Notch-1 was more frequently and diffusely seen in psoriasis. Exacerbation of psoriasis as assessed by the Psoriasis Area and Severity Index score was significantly associated with intense (P =.005) and nuclear form of Notch-1 expression (P =.0001). The nuclear form of Notch-1 was also correlated with female sex (P =.043). From this study, up-regulation and not down-regulation of Notch-1 may have a role in pathogenesis of psoriasis. The nuclear form is responsible for the exacerbation of symptoms, and it is the one that may disappear by the effect of psoralen and ultraviolet A radiation (PUVA) therapy. � 2012 Elsevier Inc.
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Keywords
Immunohistochemistry, Notch-1, Psoriasis, PUVA, Notch1 receptor, psoralen, adult, article, chronic disease, clinical article, controlled study, correlation analysis, disease exacerbation, epidermis, female, human, immunohistochemistry, male, priority journal, protein expression, Psoriasis Severity Index, psoriasis vulgaris, PUVA, skin biopsy, upregulation, Adolescent, Adult, Aged, Child, Female, Humans, Immunohistochemistry, Male, Middle Aged, Psoriasis, PUVA Therapy, Receptor, Notch1, Skin, Up-Regulation, Young Adult