Rapid validated thin-layer chromatography-densitometry for the simultaneous determination of three co-formulated drugs used for common cold treatment

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorFouad M.M.
dc.contributor.authorEl-Maraghy C.M.
dc.contributor.otherAnalytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherEgypt; Analytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAl-Azhar University
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:42Z
dc.date.available2020-01-09T20:40:42Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractA rapid validated thin-layer chromatography (TLC).densitometric method has been developed for the simultaneous determination of 3 co-formulated drugs used for common cold and cough treatment. The studied drugs are paracetamol, pseudoephedrine, and chlorpheniramine maleate. The separation was achieved using silica gel 60 F254 plates and the developing system of methanol. toluene.acetic acid (44:16:1, v/v). Densitometry scanning was performed at 254 nm. The method was validated as per the International Conference on Harmonization (ICH) guidelines and was successfully applied for the analysis of pharmaceutical preparation containing the cited ternary mixture without interference from excipients. There is no previously published TLC.densitometric method for the determination of the previously mentioned ternary mixture. The suggested method is rapid and of low cost, so it can be used for quality control analysis. 2019 Akadmiai Kiaden_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24059&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1556/1006.2019.32.2.8
dc.identifier.doiPubMed ID :
dc.identifier.issn9334173
dc.identifier.otherhttps://doi.org/10.1556/1006.2019.32.2.8
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/j62NJ
dc.language.isoEnglishen_US
dc.publisherAkademiai Kiado Rt.en_US
dc.relation.ispartofseriesJournal of Planar Chromatography - Modern TLC
dc.relation.ispartofseries32
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectChlorpheniramine maleateen_US
dc.subjectCommon colden_US
dc.subjectParacetamolen_US
dc.subjectPseudoephedrineen_US
dc.subjectThin-layer chromatography-densitometryen_US
dc.subjectDrug productsen_US
dc.subjectMixturesen_US
dc.subjectQuality controlen_US
dc.subjectSilicaen_US
dc.subjectSilica gelen_US
dc.subjectChlorpheniramine maleateen_US
dc.subjectCommon colden_US
dc.subjectDensitometric methoden_US
dc.subjectInternational conference on harmonizationsen_US
dc.subjectParacetamolen_US
dc.subjectPharmaceutical preparationsen_US
dc.subjectPseudoephedrineen_US
dc.subjectSimultaneous determinationsen_US
dc.subjectThin layer chromatographyen_US
dc.subjectacetic aciden_US
dc.subjectchlorpheniramine maleateen_US
dc.subjectmethanolen_US
dc.subjectparacetamolen_US
dc.subjectpseudoephedrineen_US
dc.subjectsilica gelen_US
dc.subjecttolueneen_US
dc.subjectArticleen_US
dc.subjectcommon colden_US
dc.subjectcomparative studyen_US
dc.subjectdensitometryen_US
dc.subjectdrug determinationen_US
dc.subjecthigh performance liquid chromatographyen_US
dc.subjectintermethod comparisonen_US
dc.subjectpharmaceuticsen_US
dc.subjectprocess optimizationen_US
dc.subjectquality controlen_US
dc.subjectthin layer chromatographyen_US
dc.subjectvalidation studyen_US
dc.titleRapid validated thin-layer chromatography-densitometry for the simultaneous determination of three co-formulated drugs used for common cold treatmenten_US
dc.typeArticleen_US
dcterms.isReferencedByYacobi, A., Stoll, R.G., Chao, G.C., Carter, J.E., Baaske, D.M., Kamath, B.L., Amann, A.H., Lai, C.M., (1980) J. Pharm. Sci., 69, pp. 1077-1081; Chua, S.S., Benrimoj, S.I., Gordon, R.D., Williams, G., (1991) Br. J. Clin. Pharmacol., 31, pp. 360-362; Brunton, L.L., Parker, K.L., (2008) Goodman & Gilman's Manual of Pharmacology and Therapeutics, , McGraw-Hill, New York, NY; Murtha, J.L., Julian, T.N., Radebaugh, G.W., (1988) J. Pharm. Sci., 77, pp. 715-718; Rohman, A., Ardiyanti, Y., Sudjadi, S., Riyanto, S., (2015) J. Med. Sci., 15, pp. 221-228; Pyreddy, V.R., Mallu, U.R., Bobbarala, V., Penumajji, S., (2011) J. Pharm. Res., 4, pp. 1225-1227; Al-Rimawi, F., (2010) Saudi Pharm. J., 18, pp. 103-106; Rajurkar, S., (2011) IJLPR, 1, pp. 94-100; Al-Akraa, H., Sarkis, N., Alshehaby, M., (2013) Int. J. Pharm. Pharm. Sci., 5, pp. 234-241; Lou, H.-G., Yuan, H., Ruan, Z.-R., Jiang, B., (2010) J. Chromatogr. B, 878, pp. 682-688; Liao, Q., Xie, Z., Pan, B., Zhu, C., Yao, M., Xu, X., Wan, J., (2008) Chromatographia, 67, pp. 687-694; Zou, H., Gao, S., Chen, W., Yanqiang, Z., Xuetao, J., Yuanying, P., (2008) Chromatographia, 68, pp. 251-257; (2005) ICH, International Conference on Harmonization, of Technical Requirements for Registration of Pharmaceuticals for Human Use Topic Q2 (R1), Validation of Analytical Procedures: Text and Methodology, , Geneva
dcterms.sourceScopus

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