Rapid validated thin-layer chromatography-densitometry for the simultaneous determination of three co-formulated drugs used for common cold treatment

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Date

2019

Journal Title

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Volume Title

Type

Article

Publisher

Akademiai Kiado Rt.

Series Info

Journal of Planar Chromatography - Modern TLC
32

Abstract

A rapid validated thin-layer chromatography (TLC).densitometric method has been developed for the simultaneous determination of 3 co-formulated drugs used for common cold and cough treatment. The studied drugs are paracetamol, pseudoephedrine, and chlorpheniramine maleate. The separation was achieved using silica gel 60 F254 plates and the developing system of methanol. toluene.acetic acid (44:16:1, v/v). Densitometry scanning was performed at 254 nm. The method was validated as per the International Conference on Harmonization (ICH) guidelines and was successfully applied for the analysis of pharmaceutical preparation containing the cited ternary mixture without interference from excipients. There is no previously published TLC.densitometric method for the determination of the previously mentioned ternary mixture. The suggested method is rapid and of low cost, so it can be used for quality control analysis. 2019 Akadmiai Kiad

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Scopus

Keywords

October University for Modern Sciences and Arts, University for Modern Sciences and Arts, MSA University, جامعة أكتوبر للعلوم الحديثة والآداب, Chlorpheniramine maleate, Common cold, Paracetamol, Pseudoephedrine, Thin-layer chromatography-densitometry, Drug products, Mixtures, Quality control, Silica, Silica gel, Chlorpheniramine maleate, Common cold, Densitometric method, International conference on harmonizations, Paracetamol, Pharmaceutical preparations, Pseudoephedrine, Simultaneous determinations, Thin layer chromatography, acetic acid, chlorpheniramine maleate, methanol, paracetamol, pseudoephedrine, silica gel, toluene, Article, common cold, comparative study, densitometry, drug determination, high performance liquid chromatography, intermethod comparison, pharmaceutics, process optimization, quality control, thin layer chromatography, validation study

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