The prognostic significance of the long non-coding RNAs “CCAT1, PVT1” in t(8;21) associated Acute Myeloid Leukemia

Simple item page
dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Khazragy N.
dc.contributor.authorElayat W.
dc.contributor.authorMatbouly S.
dc.contributor.authorSeliman S.
dc.contributor.authorSami A.
dc.contributor.authorSafwat G.
dc.contributor.authorDiab A.
dc.contributor.otherClinical Pathology and Hematology Department
dc.contributor.otherFaculty of Medicine
dc.contributor.otherAin Shams University Biomedical Research Department
dc.contributor.otherP.O. Box 11381
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Medical Biochemistry
dc.contributor.otherFaculty of Medicine
dc.contributor.otherAin Shams University
dc.contributor.otherEgypt; Department of Pediatrics
dc.contributor.otherFaculty of Medicine
dc.contributor.otherAin Shams University
dc.contributor.otherEgypt; Faculty of Biotechnology
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:35Z
dc.date.available2020-01-09T20:40:35Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractLong non-coding RNA (LncRNA) is recently linked to various types of cancers, CCAT and PVT1 are two LncRNAs linked to t(8;21) associated Acute Myeloid Leukemia, the interplay between CCAT, PVT1 and the MYC proto-oncogene implicated in t(8;21) could present an opportunity for using LncRNA as prognostic biomarker or a target for therapy, We investigated the expression levels of LncRNAs in 70 patients; 30 with t(8;21) positive AML and 40 with t(8;21) negative AML, We found that CCAT1 and PVT1 are expressed in higher levels in t(8;21) positive �AML by 5.3 folds compared to t(8;21) negative group; the expression values were significantly associated with high-risk clinical criteria; moreover, they are associated with lower overall survival (OS) rate and leukemia-free survival (LFS), however we didn't find a statistically significant cut-off value of LncRNAs using the Cox regression analysis for Lnc_PVT1 except with LFS, we conclude that high expression levels of CCAT1 and PVT1 are associated with poor prognosis while being poor prognostic biomarkers in t(8;21) associated AML. � 2019 Elsevier B.V.en_US
dc.identifier.doihttps://doi.org/10.1016/j.gene.2019.03.055
dc.identifier.doiPubMedID30943439
dc.identifier.issn3781119
dc.identifier.otherhttps://doi.org/10.1016/j.gene.2019.03.055
dc.identifier.otherPubMedID30943439
dc.identifier.urihttps://t.ly/veqn7
dc.language.isoEnglishen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofseriesGene
dc.relation.ispartofseries707
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectAcute Myeloid Leukemia (AML)en_US
dc.subjectLnc-CCAT1en_US
dc.subjectLnc-PVT1en_US
dc.subjectPrognostic factoren_US
dc.subjectt(8;21)en_US
dc.subjectlong non coding RNA CCAT1en_US
dc.subjectlong non coding RNA PVT1en_US
dc.subjectlong untranslated RNAen_US
dc.subjecttumor markeren_US
dc.subjectunclassified drugen_US
dc.subjectCCAT1 long noncoding RNA, humanen_US
dc.subjectlong untranslated RNAen_US
dc.subjectMyc proteinen_US
dc.subjectMYC protein, humanen_US
dc.subjectPVT1 long-non-coding RNA, humanen_US
dc.subjecttumor markeren_US
dc.subjectacute myeloid leukemiaen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectArticleen_US
dc.subjectcancer prognosisen_US
dc.subjectcancer specific survivalen_US
dc.subjectclinical featureen_US
dc.subjectcohort analysisen_US
dc.subjectcomparative studyen_US
dc.subjectcontrolled studyen_US
dc.subjectdemographyen_US
dc.subjectfemaleen_US
dc.subjectgene expressionen_US
dc.subjectgenetic associationen_US
dc.subjecthigh risk patienten_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectoverall survivalen_US
dc.subjectpriority journalen_US
dc.subjectrisk factoren_US
dc.subjectsurvival rateen_US
dc.subjectupregulationen_US
dc.subjectacute myeloid leukemiaen_US
dc.subjectchromosome 21en_US
dc.subjectchromosome 8en_US
dc.subjectgene expression regulationen_US
dc.subjectgene translocationen_US
dc.subjectgeneticsen_US
dc.subjectmiddle ageden_US
dc.subjectprognosisen_US
dc.subjectregression analysisen_US
dc.subjectsurvival analysisen_US
dc.subjectyoung adulten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectBiomarkers, Tumoren_US
dc.subjectChromosomes, Human, Pair 21en_US
dc.subjectChromosomes, Human, Pair 8en_US
dc.subjectFemaleen_US
dc.subjectGene Expression Regulation, Neoplasticen_US
dc.subjectHumansen_US
dc.subjectLeukemia, Myeloid, Acuteen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPrognosisen_US
dc.subjectProto-Oncogene Proteins c-mycen_US
dc.subjectRegression Analysisen_US
dc.subjectRNA, Long Noncodingen_US
dc.subjectSurvival Analysisen_US
dc.subjectTranslocation, Geneticen_US
dc.subjectUp-Regulationen_US
dc.subjectYoung Adulten_US
dc.titleThe prognostic significance of the long non-coding RNAs “CCAT1, PVT1” in t(8;21) associated Acute Myeloid Leukemiaen_US
dc.typeArticleen_US
dcterms.isReferencedByBoon, R.A., Ja�, N., Holdt, L., Dimmeler, S., Long noncoding RNAs: from clinical genetics to therapeutic targets? (2016) J. Am. Coll. Cardiol., 67 (10), pp. 1214-1226. , https://www.sciencedirect.com/science/article/pii/S0735109716002242, (Internet). (cited 2018 Jul 21). Available from:; Chen, L., Wang, W., Cao, L., Li, Z., Wang, X., Long non-coding CCAT1 acts as a competing endogenous RNA to regulate cell growth and differentiation in acute myeloid leukemia (2016) Mol. Cell, 39 (4), pp. 330-336; Fan, H., Zhu, J.-H., Yao, X.-Q., Knockdown of long non-coding RNA PVT1 reverses multidrug resistance in colorectal cancer cells (2018) Mol. Med. Rep., 17 (6), pp. 8309-8315. , http://www.ncbi.nlm.nih.gov/pubmed/29693171, (Internet). (cited 2018 Jul 31). Available from:; Fatima, R., Akhade, V.S., Pal, D., Rao, S.M., Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets (2015) Mol. Cell. Ther., 3 (1), p. 5. , http://molcelltherapies.com/article/view/30, (Internet). (cited 2018 Jul 21). Available from:; Gamis, A.S., Alonzo, T.A., Perentesis, J.P., Meshinchi, S., Children's Oncology Group's 2013 blueprint for research: acute myeloid leukemia (2013) Pediatr. Blood Cancer, 60 (6), pp. 964-971. , http://doi.wiley.com/10.1002/pbc.24432, (Internet). (cited 2018 Jun 27). Available from:; Grimwade, D., Hills, R.K., Moorman, A.V., Walker, H., Chatters, S., Goldstone, A.H., Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials (2010) Blood, 116 (3), pp. 354-365. , http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-11-254441, (Internet). (cited 2018 Jun 27). Available from:; Hamilton, M.J., Young, M.D., Sauer, S., Martinez, E., The interplay of long non-coding RNAs and MYC in cancer (2015) AIMS Biophys., 2 (4), pp. 794-809. , http://www.aimspress.com/article/10.3934/biophy.2015.4.794, (Internet). Available from:; Hu, J., Han, Q., Gu, Y., Ma, J., McGrath, M., Qiao, F., Circular RNA PVT1 expression and its roles in acute lymphoblastic leukemia (2018) Epigenomics, 10 (6), pp. 723-732. , http://www.ncbi.nlm.nih.gov/pubmed/29693417, (Internet). (cited 2018 Jul 31). Available from:; Huang, C., Yu, W., Wang, Q., Cui, H., Wang, Y., Zhang, L., Increased expression of the lncRNA PVT1 is associated with poor prognosis in pancreatic cancer patients (2015) Minerva Med., 106 (3), pp. 143-149. , http://www.ncbi.nlm.nih.gov/pubmed/25668599, (Internet). (cited 2018 Jul 21). Available from:; Izadifard, M., Pashaiefar, H., Yaghmaie, M., Montazeri, M., Sadraie, M., Momeny, M., Jalili, M., Ghavamzadeh, A., Expression analysis of PVT1, CCDC26, and CCAT1 long noncoding RNAs in acute myeloid leukemia patients (2018) Genet. Test. Mol. Biomarkers, 22 (10), pp. 593-598. , https://www.ncbi.nlm.nih.gov/pubmed/30222365, 2018 Oct. Epub 2018 Sep 14; Johansen, L.M., Iwama, A., Lodie, T.A., Sasaki, K., Felsher, D.W., Golub, T.R., c-Myc is a critical target for C/EBP in granulopoiesis (2001) Mol. Cell. Biol., 21 (11), pp. 3789-3806. , http://www.ncbi.nlm.nih.gov/pubmed/11340171, Internet. (cited 2018 Jun 27). Available from; Klein, K., Kaspers, G., Harrison, C.J., Beverloo, H.B., Reedijk, A., Bongers, M., Clinical impact of additional cytogenetic aberrations, cKIT and RAS mutations, and treatment elements in pediatric t(8;21)-AML: results from an international retrospective study by the international Berlin-Frankfurt-M�nster study group (2015) J. Clin. Oncol., 33 (36), pp. 4247-4258. , http://ascopubs.org/doi/10.1200/JCO.2015.61.1947, (Internet). (cited 2018 Jun 27). Available from:; M�ller-Tidow, C., Steffen, B., Cauvet, T., Tickenbrock, L., Ji, P., Diederichs, S., Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells (2004) Mol. Cell. Biol., 24 (7), pp. 2890-2904. , http://www.ncbi.nlm.nih.gov/pubmed/15024077, Internet. (cited 2018 Jun 27). Available from; Nucifora, G., Rowley, J.D., AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia (1995) Blood, 86 (1), pp. 1-14. , http://www.ncbi.nlm.nih.gov/pubmed/7795214, (Internet). (cited 2018 Jun 27). Available from:; Pan, J.-Q., Zhang, Y.-Q., Wang, J.-H., Xu, P., Wang, W., lncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia (2017) Int. J. Mol. Med., , http://www.spandidos-publications.com/10.3892/ijmm.2017.2888, (Internet). Available from; Quek, X.C., lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs (2015) Nucleic Acids Res., 43 (D1), pp. D168-D173; Saus, E., Brunet-Vega, A., Iraola-Guzm�n, S., Pegueroles, C., Gabald�n, T., Pericay, C., Long non-coding RNAs as potential novel prognostic biomarkers in colorectal cancer (2016) Front. Genet., 7, p. 54. , http://www.ncbi.nlm.nih.gov/pubmed/27148353, (Internet). (cited 2018 Jul 21). Available from; Siegel, R.L., Miller, K.D., Jemal, A., Cancer statistics (2017) CA Cancer J. Clin., 67 (1), pp. 7-30. , (Internet). 2017 Jan (cited 2018 Jun 27). Available from:; Slovak, M.L., Ho, J.P., Pettenati, M.J., Khan, A., Douer, D., Lal, S., Localization of amplified MYC gene sequences to double minute chromosomes in acute myelogenous leukemia (1994) Genes Chromosomes Cancer, 9 (1), pp. 62-67. , http://www.ncbi.nlm.nih.gov/pubmed/7507702, (Internet). (cited 2018 Jun 27). Available from:; Tobal, K., Newton, J., Machida, M., Chang, J., Morgenstern, G., Evans, P.A., Molecular quantitation of minimal residual disease in acute myeloid leukemia with t(8;21) can identify patients in durable remission and predict clinical relapse (2000) Blood, 95 (3), pp. 815-819. , http://www.ncbi.nlm.nih.gov/pubmed/10648391, Internet. (cited 2018 Jun 27). Available from; Wheatley, K., Burnett, A.K., Goldstone, A.H., Gray, R.G., Hann, I.M., Harrison, C.J., http://www.ncbi.nlm.nih.gov/pubmed/10520026, A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukemia derived from the MRC AML 10 trial. United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties. Br. J. Haematol. (Internet). 1999 Oct (cited 2018 Jun 27);107(1):69�79. Available from:; Yang, X., Xie, X., Xiao, Y.-F., Xie, R., Hu, C.-J., Tang, B., The emergence of long non-coding RNAs in the tumorigenesis of hepatocellular carcinoma (2015) Cancer Lett., 360 (2), pp. 119-124. , http://www.ncbi.nlm.nih.gov/pubmed/25721084, (Internet). (cited 2018 Jul 31). Available from:; Zeng, C., Yu, X., Lai, J., Yang, L., Chen, S., Li, Y., Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia (2015) J. Hematol. Oncol., 8, p. 126. , http://www.ncbi.nlm.nih.gov/pubmed/26545364, (Internet). (cited 2018 Jul 31). Available from:
dcterms.sourceScopus

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
avatar_scholar_256.png
Size:
6.31 KB
Format:
Portable Network Graphics
Description:
Download

Collections

Faculty of Biotechnology Research Paper