The prognostic significance of the long non-coding RNAs “CCAT1, PVT1” in t(8;21) associated Acute Myeloid Leukemia
Date
2019
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Elsevier B.V.
Series Info
Gene
707
707
Scientific Journal Rankings
Abstract
Long non-coding RNA (LncRNA) is recently linked to various types of cancers, CCAT and PVT1 are two LncRNAs linked to t(8;21) associated Acute Myeloid Leukemia, the interplay between CCAT, PVT1 and the MYC proto-oncogene implicated in t(8;21) could present an opportunity for using LncRNA as prognostic biomarker or a target for therapy, We investigated the expression levels of LncRNAs in 70 patients; 30 with t(8;21) positive AML and 40 with t(8;21) negative AML, We found that CCAT1 and PVT1 are expressed in higher levels in t(8;21) positive �AML by 5.3 folds compared to t(8;21) negative group; the expression values were significantly associated with high-risk clinical criteria; moreover, they are associated with lower overall survival (OS) rate and leukemia-free survival (LFS), however we didn't find a statistically significant cut-off value of LncRNAs using the Cox regression analysis for Lnc_PVT1 except with LFS, we conclude that high expression levels of CCAT1 and PVT1 are associated with poor prognosis while being poor prognostic biomarkers in t(8;21) associated AML. � 2019 Elsevier B.V.
Description
Scopus
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MSA Google Scholar
Keywords
October University for Modern Sciences and Arts, جامعة أكتوبر للعلوم الحديثة والآداب, University of Modern Sciences and Arts, MSA University, Acute Myeloid Leukemia (AML), Lnc-CCAT1, Lnc-PVT1, Prognostic factor, t(8;21), long non coding RNA CCAT1, long non coding RNA PVT1, long untranslated RNA, tumor marker, unclassified drug, CCAT1 long noncoding RNA, human, long untranslated RNA, Myc protein, MYC protein, human, PVT1 long-non-coding RNA, human, tumor marker, acute myeloid leukemia, adult, aged, Article, cancer prognosis, cancer specific survival, clinical feature, cohort analysis, comparative study, controlled study, demography, female, gene expression, genetic association, high risk patient, human, major clinical study, male, overall survival, priority journal, risk factor, survival rate, upregulation, acute myeloid leukemia, chromosome 21, chromosome 8, gene expression regulation, gene translocation, genetics, middle aged, prognosis, regression analysis, survival analysis, young adult, Adult, Aged, Biomarkers, Tumor, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 8, Female, Gene Expression Regulation, Neoplastic, Humans, Leukemia, Myeloid, Acute, Male, Middle Aged, Prognosis, Proto-Oncogene Proteins c-myc, Regression Analysis, RNA, Long Noncoding, Survival Analysis, Translocation, Genetic, Up-Regulation, Young Adult