Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on AlMo gel

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorSakr T.M.
dc.contributor.authorIbrahim A.B.
dc.contributor.authorFasih T.W.
dc.contributor.authorRashed H.M.
dc.contributor.otherRadioactive Isotopes and Generators Department
dc.contributor.otherHot Laboratories Centre
dc.contributor.otherAtomic Energy Authority
dc.contributor.otherCairo
dc.contributor.other13759
dc.contributor.otherEgypt; Pharmaceutical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University of Modern Sciences and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Labeled Compounds Department
dc.contributor.otherHot Labs Center
dc.contributor.otherAtomic Energy Authority
dc.contributor.otherP.O. Box 13759
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:10Z
dc.date.available2020-01-09T20:41:10Z
dc.date.issued2017
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractThe current study is aimed to prepare 99mTc-lidocaine as a new myocardial perfusion-imaging agent. The used 99mTc was obtained from Al. 99Mo-molybdate(VI) gel matrix. 99mTc-lidocaine showed higher (15.4. 0.11% ID/g) and faster (15. min post injection) cardiac uptake than the recently studied 99mTc-valsartan and 99mTc-procainamide. Consequently, 99mTc-lidocaine will be a valuable myocardial SPECT agent for diagnosis of emergency patients. Besides, the receptor affinity study confirmed the selectivity of 99mTc-lidocaine for sodium channels in the heart. 2017, Akadmiai Kiad, Budapest, Hungary.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24060&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1007/s10967-017-5560-z
dc.identifier.doiPubMed ID :
dc.identifier.issn2365731
dc.identifier.otherhttps://doi.org/10.1007/s10967-017-5560-z
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/R0Kzv
dc.language.isoEnglishen_US
dc.publisherSpringer Netherlandsen_US
dc.relation.ispartofseriesJournal of Radioanalytical and Nuclear Chemistry
dc.relation.ispartofseries314
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subject99Mo/99mTc generatoren_US
dc.subjectHeart imagingen_US
dc.subjectLidocaineen_US
dc.subjectMyocardial perfusionen_US
dc.subjectaluminumen_US
dc.subjectlidocaineen_US
dc.subjectmolybdenum 99en_US
dc.subjectmolybdic aciden_US
dc.subjectprocainamideen_US
dc.subjecttechnetium 99men_US
dc.subjectvalsartanen_US
dc.subjectanimal experimenten_US
dc.subjectanimal tissueen_US
dc.subjectArticleen_US
dc.subjectcardioselectivityen_US
dc.subjectcontrolled studyen_US
dc.subjectelutionen_US
dc.subjectgelen_US
dc.subjectisotope labelingen_US
dc.subjectmouseen_US
dc.subjectmyocardial perfusion imagingen_US
dc.subjectnonhumanen_US
dc.subjectradioactivityen_US
dc.subjectreceptor affinityen_US
dc.subjectstructure analysisen_US
dc.titlePreparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on AlMo gelen_US
dc.typeArticleen_US
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