Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on Al–Mo gel

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorSakr T.M.
dc.contributor.authorIbrahim A.B.
dc.contributor.authorFasih T.W.
dc.contributor.authorRashed H.M.
dc.contributor.otherOctober University of Modern Sciences and Arts (MSA)
dc.date.accessioned2020-01-09T20:41:10Z
dc.date.available2020-01-09T20:41:10Z
dc.date.issued20-10-2017
dc.descriptionSJR 2025 0.354 Q3 H-Index 81 Subject Area and Category: Chemistry Analytical Chemistry Spectroscopy Energy Nuclear Energy and Engineering Environmental Science Health, Toxicology and Mutagenesis Pollution Medicine Public Health, Environmental and Occupational Health Radiology, Nuclear Medicine and Imaging
dc.description.abstractThe current study is aimed to prepare 99mTc-lidocaine as a new myocardial perfusion-imaging agent. The used 99mTc was obtained from Al–99Mo-molybdate(VI) gel matrix. 99mTc-lidocaine showed higher (15.4 ± 0.11% ID/g) and faster (15 min post injection) cardiac uptake than the recently studied 99mTc-valsartan and 99mTc-procainamide. Consequently, 99mTc-lidocaine will be a valuable myocardial SPECT agent for diagnosis of emergency patients. Besides, the receptor affinity study confirmed the selectivity of 99mTc-lidocaine for sodium channels in the heart. en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24060&tip=sid&clean=0
dc.identifier.citationSakr, T. M., Ibrahim, A. B., Fasih, T. W., & Rashed, H. M. (2017). Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on Al–Mo gel. Journal of Radioanalytical and Nuclear Chemistry, 314(3), 2091–2098. https://doi.org/10.1007/s10967-017-5560-z ‌
dc.identifier.doihttps://doi.org/10.1007/s10967-017-5560-z
dc.identifier.issn2365731
dc.identifier.otherhttps://doi.org/10.1007/s10967-017-5560-z
dc.identifier.urihttps://t.ly/R0Kzv
dc.language.isoEnglishen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofseriesJournal of Radioanalytical and Nuclear Chemistry ; Volume 314 , Issue 3 , pages 2091–2098 , (2017)
dc.subjectMyocardial perfusion; 99Mo/99mTc generator; Lidocaine; Heart imaging
dc.titlePreparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on Al–Mo gelen_US
dc.typeArticleen_US
dcterms.sourceScopus

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