Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on AlMo gel
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Springer Netherlands
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Journal of Radioanalytical and Nuclear Chemistry
314
314
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Abstract
The current study is aimed to prepare 99mTc-lidocaine as a new myocardial perfusion-imaging agent. The used 99mTc was obtained from Al. 99Mo-molybdate(VI) gel matrix. 99mTc-lidocaine showed higher (15.4. 0.11% ID/g) and faster (15. min post injection) cardiac uptake than the recently studied 99mTc-valsartan and 99mTc-procainamide. Consequently, 99mTc-lidocaine will be a valuable myocardial SPECT agent for diagnosis of emergency patients. Besides, the receptor affinity study confirmed the selectivity of 99mTc-lidocaine for sodium channels in the heart. 2017, Akadmiai Kiad, Budapest, Hungary.
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Keywords
October University for Modern Sciences and Arts, University for Modern Sciences and Arts, MSA University, جامعة أكتوبر للعلوم الحديثة والآداب, 99Mo/99mTc generator, Heart imaging, Lidocaine, Myocardial perfusion, aluminum, lidocaine, molybdenum 99, molybdic acid, procainamide, technetium 99m, valsartan, animal experiment, animal tissue, Article, cardioselectivity, controlled study, elution, gel, isotope labeling, mouse, myocardial perfusion imaging, nonhuman, radioactivity, receptor affinity, structure analysis