Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on Al–Mo gel
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Springer Nature
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Journal of Radioanalytical and Nuclear Chemistry ; Volume 314 , Issue 3 , pages 2091–2098 , (2017)
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Abstract
The current study is aimed to prepare 99mTc-lidocaine as a new myocardial perfusion-imaging agent. The used 99mTc was obtained from Al–99Mo-molybdate(VI) gel matrix. 99mTc-lidocaine showed higher (15.4 ± 0.11% ID/g) and faster (15 min post injection) cardiac uptake than the recently studied 99mTc-valsartan and 99mTc-procainamide. Consequently, 99mTc-lidocaine will be a valuable myocardial SPECT agent for diagnosis of emergency patients. Besides, the receptor affinity study confirmed the selectivity of 99mTc-lidocaine for sodium channels in the heart.
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SJR 2025
0.354
Q3
H-Index
81
Subject Area and Category:
Chemistry
Analytical Chemistry
Spectroscopy
Energy
Nuclear Energy and Engineering
Environmental Science
Health, Toxicology and Mutagenesis
Pollution
Medicine
Public Health, Environmental and Occupational Health
Radiology, Nuclear Medicine and Imaging
Citation
Sakr, T. M., Ibrahim, A. B., Fasih, T. W., & Rashed, H. M. (2017). Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on Al–Mo gel. Journal of Radioanalytical and Nuclear Chemistry, 314(3), 2091–2098. https://doi.org/10.1007/s10967-017-5560-z