Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Feky G.S.
dc.contributor.authorAbdulmaguid R.F.
dc.contributor.authorZayed G.M.
dc.contributor.authorKamel R.
dc.contributor.otherDepartment of Pharmaceutical Technology
dc.contributor.otherNational Research Center
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Pharmaceutics
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Oral Medicine and Periodontology
dc.contributor.otherDepartment Faculty of Dentistry
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Pharmaceutics and Industrial Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAl-Azhar University at Assiut
dc.contributor.otherAssiut
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:06Z
dc.date.available2020-01-09T20:41:06Z
dc.date.issued2018
dc.descriptionScopus
dc.description.abstractThe current study aimed to investigate the effectiveness of a developed sodium alginate and polyvinyl-pyrrolidone K-25 (PVP K-25) polymeric wafer for the co-delivery of ketorolac and lidocaine to soft tissues for healing and pain control following gingivectomy. Nine ketorolac/lidocaine lyophilized wafers were formulated and assessed for their hydration capacity, mucoadhesion ability and in vitro release profile to select the optimum system for further clinical investigation. Wafer F6 containing 2:1 sodium alginate to PVP K-25 and 10% glycerol showed optimum properties and was selected for the clinical study. Twenty patients were included in the study and the ketorolac/lidocaine wafer was assessed versus a market product. Visual pain analog was evaluated daily for the first week and wound healing index was evaluated for one week, two weeks and one month following the procedure. The developed ketorolac/lidocaine polymeric wafer proved to be an effective method of reducing pain and discomfort together with enhancing wound healing following gingivectomy. � 2017 The Author(s).en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=20770&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1080/10717544.2017.1413445
dc.identifier.doiPubMed ID 29226726
dc.identifier.issn10717544
dc.identifier.otherhttps://doi.org/10.1080/10717544.2017.1413445
dc.identifier.otherPubMed ID 29226726
dc.identifier.urihttps://t.ly/lW82R
dc.language.isoEnglishen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofseriesDrug Delivery
dc.relation.ispartofseries25
dc.subjectGingivectomyen_US
dc.subjectKetorolac/lidocaine waferen_US
dc.subjectPolyvinylpyrrolidone K-25en_US
dc.subjectSodium alginateen_US
dc.subjectVisual analogue scale (VAS)en_US
dc.subjectWound healing index (WHI)en_US
dc.subjectalginic aciden_US
dc.subjectglycerolen_US
dc.subjectketorolac trometamolen_US
dc.subjectlidocaineen_US
dc.subjectpovidoneen_US
dc.subjectalginic aciden_US
dc.subjectglucuronic aciden_US
dc.subjecthexuronic aciden_US
dc.subjectketorolacen_US
dc.subjectlidocaineen_US
dc.subjectlocal anesthetic agenten_US
dc.subjectnonsteroid antiinflammatory agenten_US
dc.subjectpolymeren_US
dc.subjectpovidoneen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectageen_US
dc.subjectArticleen_US
dc.subjectbone metabolismen_US
dc.subjectclinical articleen_US
dc.subjectcrown lengtheningen_US
dc.subjectdental procedureen_US
dc.subjectdrug distributionen_US
dc.subjectdrug formulationen_US
dc.subjecteffective concentrationen_US
dc.subjectex vivo studyen_US
dc.subjectfreeze dryingen_US
dc.subjectgingivectomyen_US
dc.subjecthumanen_US
dc.subjecthydrationen_US
dc.subjectin vitro studyen_US
dc.subjectinflammationen_US
dc.subjectmucoadhesionen_US
dc.subjectpostoperative painen_US
dc.subjectpriority journalen_US
dc.subjectscanning electron microscopyen_US
dc.subjectvisual analog scaleen_US
dc.subjectwater absorptionen_US
dc.subjectwound fluiden_US
dc.subjectwound healingen_US
dc.subjectchemistryen_US
dc.subjectdrug delivery systemen_US
dc.subjectdrug effecten_US
dc.subjectfemaleen_US
dc.subjectmaleen_US
dc.subjectmetabolismen_US
dc.subjectmouth mucosaen_US
dc.subjectpainen_US
dc.subjectpain measurementen_US
dc.subjectproceduresen_US
dc.subjectwound healingen_US
dc.subjectyoung adulten_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAlginatesen_US
dc.subjectAnesthetics, Localen_US
dc.subjectAnti-Inflammatory Agents, Non-Steroidalen_US
dc.subjectDrug Delivery Systemsen_US
dc.subjectFemaleen_US
dc.subjectGingivectomyen_US
dc.subjectGlucuronic Aciden_US
dc.subjectHexuronic Acidsen_US
dc.subjectHumansen_US
dc.subjectKetorolacen_US
dc.subjectLidocaineen_US
dc.subjectMaleen_US
dc.subjectMouth Mucosaen_US
dc.subjectPainen_US
dc.subjectPain Measurementen_US
dc.subjectPolymersen_US
dc.subjectPovidoneen_US
dc.subjectWound Healingen_US
dc.subjectYoung Adulten_US
dc.titleMucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental applicationen_US
dc.typeArticleen_US
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