Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application
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Date
2018
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Taylor and Francis Ltd
Series Info
Drug Delivery
25
25
Scientific Journal Rankings
Abstract
The current study aimed to investigate the effectiveness of a developed sodium alginate and polyvinyl-pyrrolidone K-25 (PVP K-25) polymeric wafer for the co-delivery of ketorolac and lidocaine to soft tissues for healing and pain control following gingivectomy. Nine ketorolac/lidocaine lyophilized wafers were formulated and assessed for their hydration capacity, mucoadhesion ability and in vitro release profile to select the optimum system for further clinical investigation. Wafer F6 containing 2:1 sodium alginate to PVP K-25 and 10% glycerol showed optimum properties and was selected for the clinical study. Twenty patients were included in the study and the ketorolac/lidocaine wafer was assessed versus a market product. Visual pain analog was evaluated daily for the first week and wound healing index was evaluated for one week, two weeks and one month following the procedure. The developed ketorolac/lidocaine polymeric wafer proved to be an effective method of reducing pain and discomfort together with enhancing wound healing following gingivectomy. � 2017 The Author(s).
Description
Scopus
Keywords
Gingivectomy, Ketorolac/lidocaine wafer, Polyvinylpyrrolidone K-25, Sodium alginate, Visual analogue scale (VAS), Wound healing index (WHI), alginic acid, glycerol, ketorolac trometamol, lidocaine, povidone, alginic acid, glucuronic acid, hexuronic acid, ketorolac, lidocaine, local anesthetic agent, nonsteroid antiinflammatory agent, polymer, povidone, adolescent, adult, age, Article, bone metabolism, clinical article, crown lengthening, dental procedure, drug distribution, drug formulation, effective concentration, ex vivo study, freeze drying, gingivectomy, human, hydration, in vitro study, inflammation, mucoadhesion, postoperative pain, priority journal, scanning electron microscopy, visual analog scale, water absorption, wound fluid, wound healing, chemistry, drug delivery system, drug effect, female, male, metabolism, mouth mucosa, pain, pain measurement, procedures, wound healing, young adult, Adolescent, Adult, Alginates, Anesthetics, Local, Anti-Inflammatory Agents, Non-Steroidal, Drug Delivery Systems, Female, Gingivectomy, Glucuronic Acid, Hexuronic Acids, Humans, Ketorolac, Lidocaine, Male, Mouth Mucosa, Pain, Pain Measurement, Polymers, Povidone, Wound Healing, Young Adult