Synthesis of hydrazide-hydrazone derivatives and their evaluation of antidepressant, sedative and analgesic agents

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohareb R.M.
dc.contributor.authorEl-Sharkawy K.A.
dc.contributor.authorHussein M.M.
dc.contributor.authorEl-Sehrawi H.M.
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOrganic Chemistry Department
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherEl-Wahat Road
dc.contributor.other6 October City
dc.contributor.otherEgypt; Department of Chemistry
dc.contributor.otherFaculty of Science
dc.contributor.otherCairo University
dc.contributor.otherGiza
dc.contributor.otherA. R
dc.contributor.otherEgypt; Faculty of Pharmacy (Girls)
dc.contributor.otherPharmaceutical Chemistry Department
dc.contributor.otherAl-Azhar University
dc.contributor.otherNasr City
dc.contributor.otherCairo
dc.contributor.otherA. R
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:33Z
dc.date.available2020-01-25T19:58:33Z
dc.date.issued2010
dc.descriptionScopus
dc.description.abstractThe reaction of cyanoacetylhydrazine (1) with ?-bromo(4-methoxyacetophenone) (2) gave the hydrazide-hydrazone derivative 3. Compound 3 reacted with either potassium cyanide or potassium thiocyanide to give the cyanide or thiocyanide derivatives 4a or 4b respectively. The reaction of compound 3 with either hydrazine hydrate or phenylhydrazine gave the hydrazine derivatives 6a or 6b respectively. The latter compounds underwent a series of heterocyclization when react with different reagents to give 1,3,4-triazine and pyridine derivatives. The antidepressant, sedative and analgesic activities of the newly synthesized products were evaluated.en_US
dc.identifier.doihttps://doi.org/
dc.identifier.issn9751459
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://t.ly/w1mAx
dc.language.isoEnglishen_US
dc.relation.ispartofseriesJournal of Pharmaceutical Sciences and Research
dc.relation.ispartofseries2
dc.subject1,3,4-triazineen_US
dc.subjectAntidepressanten_US
dc.subjectHydrazide-hydrazoneen_US
dc.subjectPyridineen_US
dc.subjectSedativeen_US
dc.subject3 cyano 4,6 dimethyl 2 oxo 1 imino (4 methoxy omega hydrazinoacetophenonylidieno)pyridineen_US
dc.subject3 cyano 6 hydroxy 4 methyl 2 oxo 1 imino(4 methoxy omega hydrazinoacetophenoylidieno)pyridineen_US
dc.subject4 amino 5 h 6 (4 methoxyphenyl) 3 (alpha phenylhydrazoacetonitrilo) 1,2,4 triazineen_US
dc.subject4 amino 5 h 6 (4 methoxyphenyl) 3 [alpha (3 cyano 2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiophene)acetonitrilo] 1,2,4 triazineen_US
dc.subject4 methoxy omega bromoacetophenone cyanoacetylhydrazoneen_US
dc.subject4 methoxy omega cyanoacetophenone cyanoacetylhydrazoneen_US
dc.subject4 methoxy omega hydrazinoacetophenone cyanoacetylhydrazoneen_US
dc.subject4 methoxy omega phenylhydrazinoacetophenone cyanoacetylhydrazoneen_US
dc.subject4 methoxy omega thiocyanoacetophenone cyanoacetylhydrazoneen_US
dc.subject4 phenylamino 5 h 6 (4 methoxyphenyl) 3 (alpha phenylhydrazoacetonitrilo) 1,2,4 triazineen_US
dc.subject4 phenylamino 6 (4 methoxyphenyl) 3 [alpha (3 cyano 2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiopene)acetonitrilo] 1,2,4 triazineen_US
dc.subjectalpha benzal 4 methoxy omega hydrazinoacetophenone cyanoacetylhydrazoneen_US
dc.subjectalpha benzal 4 methoxy omega phenylhydrazinoacetophenone cyanoacetylhydrazoneen_US
dc.subjectethyl 4 amino 5 h 6 (4 methoxyphenyl) 3 [alpha (2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiophene 3 carboxylate)acetonitrilo] 1,2,4 triazineen_US
dc.subjectethyl 4 phenylamino 6 (4 methoxyphenyl) 3 [alpha (2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiopen 3 carboxylate)acetonitrilo] 1,2,4 triazineen_US
dc.subjecthydrazine derivativeen_US
dc.subjecthydrazone derivativeen_US
dc.subjectimipramineen_US
dc.subjectindometacinen_US
dc.subjectunclassified drugen_US
dc.subjectanalgesic activityen_US
dc.subjectanimal experimenten_US
dc.subjectantidepressant activityen_US
dc.subjectarticleen_US
dc.subjectcontrolled studyen_US
dc.subjectcyclizationen_US
dc.subjectdrug determinationen_US
dc.subjectdrug mechanismen_US
dc.subjectdrug megadoseen_US
dc.subjectdrug potencyen_US
dc.subjectdrug screeningen_US
dc.subjectdrug structureen_US
dc.subjectdrug synthesisen_US
dc.subjectexperimental mouseen_US
dc.subjectfemaleen_US
dc.subjectforced swimming testen_US
dc.subjectlow drug doseen_US
dc.subjectmaleen_US
dc.subjectmotor activityen_US
dc.subjectmouseen_US
dc.subjectnonhumanen_US
dc.subjectsedationen_US
dc.titleSynthesis of hydrazide-hydrazone derivatives and their evaluation of antidepressant, sedative and analgesic agentsen_US
dc.typeArticleen_US
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