Synthesis of hydrazide-hydrazone derivatives and their evaluation of antidepressant, sedative and analgesic agents
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Date
2010
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Series Info
Journal of Pharmaceutical Sciences and Research
2
2
Doi
Scientific Journal Rankings
Abstract
The reaction of cyanoacetylhydrazine (1) with ?-bromo(4-methoxyacetophenone) (2) gave the hydrazide-hydrazone derivative 3. Compound 3 reacted with either potassium cyanide or potassium thiocyanide to give the cyanide or thiocyanide derivatives 4a or 4b respectively. The reaction of compound 3 with either hydrazine hydrate or phenylhydrazine gave the hydrazine derivatives 6a or 6b respectively. The latter compounds underwent a series of heterocyclization when react with different reagents to give 1,3,4-triazine and pyridine derivatives. The antidepressant, sedative and analgesic activities of the newly synthesized products were evaluated.
Description
Scopus
Keywords
1,3,4-triazine, Antidepressant, Hydrazide-hydrazone, Pyridine, Sedative, 3 cyano 4,6 dimethyl 2 oxo 1 imino (4 methoxy omega hydrazinoacetophenonylidieno)pyridine, 3 cyano 6 hydroxy 4 methyl 2 oxo 1 imino(4 methoxy omega hydrazinoacetophenoylidieno)pyridine, 4 amino 5 h 6 (4 methoxyphenyl) 3 (alpha phenylhydrazoacetonitrilo) 1,2,4 triazine, 4 amino 5 h 6 (4 methoxyphenyl) 3 [alpha (3 cyano 2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiophene)acetonitrilo] 1,2,4 triazine, 4 methoxy omega bromoacetophenone cyanoacetylhydrazone, 4 methoxy omega cyanoacetophenone cyanoacetylhydrazone, 4 methoxy omega hydrazinoacetophenone cyanoacetylhydrazone, 4 methoxy omega phenylhydrazinoacetophenone cyanoacetylhydrazone, 4 methoxy omega thiocyanoacetophenone cyanoacetylhydrazone, 4 phenylamino 5 h 6 (4 methoxyphenyl) 3 (alpha phenylhydrazoacetonitrilo) 1,2,4 triazine, 4 phenylamino 6 (4 methoxyphenyl) 3 [alpha (3 cyano 2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiopene)acetonitrilo] 1,2,4 triazine, alpha benzal 4 methoxy omega hydrazinoacetophenone cyanoacetylhydrazone, alpha benzal 4 methoxy omega phenylhydrazinoacetophenone cyanoacetylhydrazone, ethyl 4 amino 5 h 6 (4 methoxyphenyl) 3 [alpha (2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiophene 3 carboxylate)acetonitrilo] 1,2,4 triazine, ethyl 4 phenylamino 6 (4 methoxyphenyl) 3 [alpha (2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiopen 3 carboxylate)acetonitrilo] 1,2,4 triazine, hydrazine derivative, hydrazone derivative, imipramine, indometacin, unclassified drug, analgesic activity, animal experiment, antidepressant activity, article, controlled study, cyclization, drug determination, drug mechanism, drug megadose, drug potency, drug screening, drug structure, drug synthesis, experimental mouse, female, forced swimming test, low drug dose, male, motor activity, mouse, nonhuman, sedation