The role of nitric oxide from neurological disease to cancer

Simple item page
dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMaher A.
dc.contributor.authorAbdel Rahman M.F.
dc.contributor.authorGad M.Z.
dc.contributor.otherBiochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherCairo
dc.contributor.otherEgypt; Clinical Biochemistry Unit
dc.contributor.otherFaculty of Pharmacy & Biotechnology
dc.contributor.otherGerman University in Cairo (GUC)
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:25Z
dc.date.available2020-01-09T20:41:25Z
dc.date.issued2017
dc.descriptionScopus
dc.description.abstractUntil the beginning of the 1980s, nitric oxide (NO) was just a toxic molecule of a lengthy list of environmental pollutants such as cigarette smoke and smog. In fact, NO had a very bad reputation of being destroyer of ozone, suspected carcinogen and precursor of acid rain. However, by the early 1990s it was well recognized by the medical research community. Over the last two decades, the picture has been totally changed. Diverse lines of evidence have converged to show that this sometime poison is a fundamental player in the everyday business of the human body. NO activity was probed in the brain, arteries, immune system, liver, pancreas, uterus, peripheral nerves, lungs, and almost every system in the human body. NO is a major player in the cardiovascular system as it is involved in regulating blood pressure. In the CNS, it is involved in memory formation and the regulation of cerebral blood flow to ensure adequate supply of blood to the brain. Because NO is involved in many pathways, it has a role in several diseases related to modern life as hypertension, coronary heart diseases, Alzheimer�s Disease, stroke and cancer. This chapter focuses on the discussion of the role of NO in neurological diseases and cancer and how can this Janus-faced molecule play a role in the pathology and personalized treatment of these diseases. � American Association of Pharmaceutical Scientists 2017.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=26761&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1007/978-3-319-60733-7_5
dc.identifier.doiPubMed ID 28840553
dc.identifier.issn652598
dc.identifier.otherhttps://doi.org/10.1007/978-3-319-60733-7_5
dc.identifier.otherPubMed ID 28840553
dc.identifier.urihttps://t.ly/Lv9yg
dc.language.isoEnglishen_US
dc.publisherSpringer New York LLCen_US
dc.relation.ispartofseriesAdvances in Experimental Medicine and Biology
dc.relation.ispartofseries1007
dc.subjectCanceren_US
dc.subjectCNSen_US
dc.subjectNeurodegeneration disordersen_US
dc.subjectNitric oxide (NO)en_US
dc.subjectNO signal transductionen_US
dc.subjectNO-targeted therapyen_US
dc.subjectNOS expressionen_US
dc.subjectacetylsalicylic aciden_US
dc.subjectantineoplastic agenten_US
dc.subjectcaspaseen_US
dc.subjectcyclic GMPen_US
dc.subjectcyclin dependent kinase 5en_US
dc.subjectdynamin related protein 1en_US
dc.subjectenzyme inhibitoren_US
dc.subjectglyceraldehyde 3 phosphate dehydrogenaseen_US
dc.subjectgt 094en_US
dc.subjectguanosine triphosphataseen_US
dc.subjectinducible nitric oxide synthaseen_US
dc.subjectmyocyte enhancer factor 2en_US
dc.subjectnitric oxideen_US
dc.subjectnitric oxide donoren_US
dc.subjectparkinen_US
dc.subjectprotein disulfide isomeraseen_US
dc.subjectprotein p53en_US
dc.subjectunclassified drugen_US
dc.subjectX linked inhibitor of apoptosisen_US
dc.subjectnitric oxideen_US
dc.subjectAlzheimer diseaseen_US
dc.subjectbrain blood flowen_US
dc.subjectcancer risken_US
dc.subjectcarcinogenesisen_US
dc.subjectcardiovascular systemen_US
dc.subjectcaveolaen_US
dc.subjectcell deathen_US
dc.subjectcell levelen_US
dc.subjectcerebrovascular accidenten_US
dc.subjectcognitionen_US
dc.subjectdisorders of mitochondrial functionsen_US
dc.subjectDNA polymorphismen_US
dc.subjectdrug activityen_US
dc.subjectdrug targetingen_US
dc.subjectgenotoxicityen_US
dc.subjecthumanen_US
dc.subjectmalignant neoplasmen_US
dc.subjectmemoryen_US
dc.subjectmetastasisen_US
dc.subjectnerve cell plasticityen_US
dc.subjectneurologic diseaseen_US
dc.subjectneuroprotectionen_US
dc.subjectneurotoxicityen_US
dc.subjectpriority journalen_US
dc.subjectprotein misfoldingen_US
dc.subjectsignal transductionen_US
dc.subjectsynthesisen_US
dc.subjecttissue levelen_US
dc.subjecttumor suppressor geneen_US
dc.subjectvascularizationen_US
dc.subjectanimalen_US
dc.subjectblood pressureen_US
dc.subjectbrain circulationen_US
dc.subjectbrain diseaseen_US
dc.subjectmetabolismen_US
dc.subjectneoplasmen_US
dc.subjectphysiologyen_US
dc.subjectAnimalsen_US
dc.subjectBlood Pressureen_US
dc.subjectBrain Diseasesen_US
dc.subjectCerebrovascular Circulationen_US
dc.subjectHumansen_US
dc.subjectNeoplasmsen_US
dc.subjectNitric Oxideen_US
dc.titleThe role of nitric oxide from neurological disease to canceren_US
dc.typeBook Chapteren_US
dcterms.isReferencedByMoncada, S., Palmer, R.M., Higgs, E.A., The discovery of nitric oxide as the endogenous nitrovaso-dilator (1988) Hypertension, 12, pp. 365-372; Ignarro, L.J., Endothelium-derived nitric oxide: Actions and properties (1989) FASEB J, 3, pp. 31-36; Murad, F., Nitric oxide: The coming of the second messenger (2011) Rambam Maimonides Med J, 2; Thomas, D.D., Breathing new life into nitric oxide signaling: A brief overview of the interplay between oxygen and nitric oxide (2015) Redox Biol, 5, pp. 225-233; Forstermann, U., Sessa, W.C., Nitric oxide synthases: Regulation and function (2012) Eur Heart J, 33, pp. 829-837; Alderton, W.K., Cooper, C.E., Knowles, R.G., Nitric oxide synthases: Structure, function and inhibition (2001) Biochem J, 357, pp. 593-615; Bian, K., Murad, F., What is next in nitric oxide research? From cardiovascular system to cancer biology (2014) Nitric Oxide, 43, pp. 3-7; El-Sehemy, A., Postovit, L.-M., Fu, Y., Nitric oxide signaling in human ovarian cancer: A potential therapeutic target (2016) Nitric Oxide Biol Chem, 54, pp. 30-37; Adams, L., Franco, M.C., Estevez, A.G., Reactive nitrogen species in cellular signaling (2015) Exp Biol Med (Maywood), 240, pp. 711-717; (2006) Public Health Challenges WHO Library Cataloguing-In-Publication Data, , World Health Organization; Thakur, K.T., Chapter 5 Neurological disorders (2016) Ment Neurol Subst Use Disord Dis Control Priorities, Third Ed, 4, p. 265; Jiang, Z., Role of nitric oxide synthases in early blood-brain barrier disruption following transient focal cerebral ischemia (2014) Plos One, 9; Kudlow, P., Cha, D.S., Carvalho, A.F., McIntyre, R.S., Nitric oxide and major depressive disorder: Pathophysiology and treatment implications (2016) Curr Mol Med, 16, pp. 206-215; Calabrese, V., Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity (2007) Nat Rev Neurosci, 8, pp. 766-775; Benarroch, E.E., Nitric oxide: A pleiotropic signal in the nervous system (2011) Neurology, 77, pp. 1568-1576; Pierrefiche, O., Naassila, M., Endogenous nitric oxide but not exogenous no-donor S-nitroprussiate facilitates NMDA excitation in spontaneous rhythmic neonatal rat brainstem slice (2014) Brain Res, 1543, pp. 9-16; Prast, H., Philippu, A., Nitric oxide as modulator of neuronal function (2001) Prog Neurobiol, 64, pp. 51-68; Dash, P.R., Fas ligand-induced apoptosis is regulated by nitric oxide through the inhibition of fas receptor clustering and the nitrosylation of protein kinase C? (2007) Exp Cell Res, 313, pp. 3421-3431; Benarroch, E.E., NMDA receptors: Recent insights and clinical correlations (2011) Neurology, 76, pp. 1750-1757; Um, H.-C., Jang, J.-H., Kim, D.-H., Lee, C., Surh, Y.-J., Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells (2011) Nitric Oxide, 25, pp. 161-168; Knott, A.B., Bossy-Wetzel, E., Nitric oxide in halth and disease of the nervous system (2009) Antioxid Redox Signal, 11, pp. 541-553; Nakamura, T., Lipton, S.A., Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases (2011) Cell Death Differ, 18, pp. 1478-1486; Linares, D., Neuronal nitric oxide synthase plays a key role in CNS demyelination (2006) J Neurosci, 26, pp. 12672-12681; Calabrese, V., Nitric oxide in cell survival: A janus molecule (2009) Antioxid Redox Signal, 11, pp. 2717-2739; 2016 Alzheimer�s disease facts and figures (2016) Alzheimers Dement, 12, pp. 459-509; Rivera, D.S., Inestrosa, N.C., Bozinovic, F., On cognitive ecology and the environmental factors that promote Alzheimer disease: Lessons from Octodon degus (Rodentia: Octodontidae) (2016) Biol Res, 49, p. 10; Querfurth, H.W., Laferla, F.M., Alzheimer�s Disease (2010) N Engl J Med, 362, pp. 329-344; Berridge, M.J., Calcium regulation of neural rhythms, memory and Alzheimer�s disease (2014) J Physiol, 592, pp. 281-293; Iqbal, K., Liu, F., Gong, C.-X., Alzheimer disease therapeutics: Focus on the disease and not just plaques and tangles (2014) Biochem Pharmacol, 88, pp. 631-639; Bird, T.D., Genetic aspects of Alzheimer disease (2008) Genet Med, 10, pp. 231-239; Holmes, C., Systemic inflammation and disease progression in Alzheimer disease (2009) Neurology, 73, pp. 768-774; Balez, R., Ooi, L., Getting to NO Alzheimer�s disease: Neuroprotection versus neurotoxicity mediated by nitric oxide (2016) Oxidative Med Cell Longev, 2016; Guo, H., FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects (2017) Neuropharmacology, 116, pp. 260-269; Franco, M.C., Nitration of Hsp90 on tyrosine 33 regulates mitochondrial metabolism (2015) J Biol Chem, 290, pp. 19055-19066; Guivernau, B., Amyloid- peptide nitrotyros-ination stabilizes oligomers and enhances NMDAR-mediated toxicity (2016) J Neurosci, 36, pp. 11693-11703; Ryan, S.D., Isogenic human iPSC parkinson�s model shows nitrosative stress-induced dysfunction in MEF2-PGC1? transcription (2013) Cell, 155, pp. 1351-1364; Nakamura, T., Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases (2015) Neurobiol Dis, 84, pp. 99-108; Xu, B., Alpha-synuclein oligomerization in manganese-induced nerve cell injury in brain slices: A role of NO-mediated S-nitrosylation of protein disulfide isomerase (2014) Mol Neurobiol, 50, pp. 1098-1110; Uehara, T., S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration (2006) Nature, 441, pp. 513-517; Benskey, M.J., Perez, R.G., Manfredsson, F.P., The contribution of alpha synuclein to neuronal survival and function � implications for Parkinson�s disease (2016) J Neurochem, 137, pp. 331-359; Cho, D.-H., Nakamura, T., Lipton, S.A., Mitochondrial dynamics in cell death and neurodegeneration (2010) Cell Mol Life Sci, 67, pp. 3435-3447; Haun, F., S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in huntington�s disease (2013) Antioxid Redox Signal, 19, pp. 1173-1184; Qu, J., S-nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by -amyloid peptide (2011) Proc Natl Acad Sci, 108, pp. 14330-14335; Nakamura, T., Cho, D.-H., Lipton, S.A., Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases (2012) Exp Neurol, 238, pp. 12-21; Bae, B.-I., Mutant huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH (2006) Proc Natl Acad Sci, 103, pp. 3405-3409; Wu, H., Caspases: A molecular switch node in the crosstalk between autophagy and apoptosis (2014) Int J Biol Sci, 10, pp. 1072-1083; Tsang, A.H.K., S-nitrosylation of XIAP compromises neuronal survival in Parkinson�s disease (2009) Proc Natl Acad Sci U S A, 106, pp. 4900-4905; Nakamura, T., Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death (2010) Mol Cell, 39, pp. 184-195; Nakamura, T., Lipton, S.A., Protein S-nitrosylation as a therapeutic target for neurodegenerative diseases (2016) Trends Pharmacol Sci, 37, pp. 73-84; Okamoto, S., Lipton, S.A., S-nitrosylation in neurogenesis and neuronal development (2015) Biochim Biophys Acta, 1850, pp. 1588-1593; Garry, P.S., Ezra, M., Rowland, M.J., Westbrook, J., Pattinson, K.T.S., The role of the nitric oxide pathway in brain injury and its treatment � from bench to bedside (2015) Exp Neurol, 263, pp. 235-243; Attwell, D., Glial and neuronal control of brain blood flow (2010) Nature, 468, pp. 232-243; Minamino, T., Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation: Role of nitric oxide (1998) Circulation, 98, pp. 1721-1727; Sabri, M., Mechanisms of microthrombi formation after experimental subarachnoid hemorrhage (2012) Neuroscience, 224, pp. 26-37; Dreier, J.P., Reiffurth, C., The stroke-migraine depolarization continuum (2015) Neuron, 86, pp. 902-922; Kim, J.Y., Park, J., Chang, J.Y., Kim, S.-H., Lee, J.E., Inflammation after ischemic stroke: The role of leukocytes and glial cells (2016) Exp Neurobiol, 25, pp. 241-251; Garcia-Bonilla, L., Inducible nitric oxide synthase in neutrophils and endothelium contributes to ischemic brain injury in mice (2014) J Immunol, 193, pp. 2531-2537; Ridnour, L.A., The biphasic nature of nitric oxide responses in tumor biology (2006) Antioxid Redox Signal, 8, pp. 1329-1337; Mart�nez, M.C., Andriantsitohaina, R., Reactive nitrogen species: Molecular mechanisms and potential significance in health and disease (2009) Antioxid Redox Signal, 11, pp. 669-702; Oronsky, B., Fanger, G.R., Oronsky, N., Knox, S., Scicinski, J., The implications of hyponitroxia in cancer (2014) Transl Oncol, 7, pp. 167-173; Lechner, M., Lirk, P., Rieder, J., Inducible nitric oxide synthase (INOS) in tumor biology: The two sides of the same coin (2005) Semin Cancer Biol, 15, pp. 277-289; Ridnour, L.A., Molecular mechanisms for discrete nitric oxide levels in cancer (2008) Nitric Oxide, 19, pp. 73-76; Vannini, F., Kashfi, K., Nath, N., The dual role of iNOS in cancer (2015) Redox Biol, 6, pp. 334-343; Criss, W.E., Murad, F., Kimura, H., Morris, H.P., Properties of guanylate cyclase in adult rat liver and several Morris hepatomas (1976) Biochim Biophys Acta Enzymol, 445, pp. 500-508; Zhu, H., Restoring soluble guanylyl cyclase expression and function blocks the aggressive course of glioma (2011) Mol Pharmacol, 80, p. 1076; Singh, S.K., Identification of human brain tumour initiating cells (2004) Nature, 432, pp. 396-401; Albina, J.E., Cui, S., Mateo, R.B., Reichner, J.S., Nitric oxide-mediated apoptosis in murine peritoneal macrophages (1993) J Immunol, 150, pp. 5080-5085; Messmer, U.K., Br�ne, B., Nitric oxide-induced apoptosis: P53-dependent and p53-independent signalling pathways (1996) Biochem J, 319, pp. 299-305; Chipuk, J.E., Direct activation of bax by p53 mediates mitochondrial membrane permeabili-zation and apoptosis (2004) Science, 80, pp. 1010-1014; Mihara, M., P53 has a direct apoptogenic role at the mitochondria (2003) Mol Cell, 11, pp. 577-590; Tovar, C., MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models (2013) Cancer Res, 73, pp. 2587-2597; Lujambio, A., Non-cell-autonomous tumor suppression by p53 (2013) Cell, 153, pp. 449-460; Strasser, A., Harris, A.W., Jacks, T., Cory, S., DNA damage can induce apoptosis in proliferat- ing lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2 (1994) Cell, 79, pp. 329-339; Bicknell, G.R., Snowden, R.T., Cohen, G.M., Formation of high molecular mass DNA fragments is a marker of apoptosis in the human leukaemic cell line, U937 (1994) J Cell Sci, 107, p. 2483; Xu, W., Lliu, L.Z., Loizidou, M., Ahmed, M., Charles, I.G., The role of nitric oxide in cancer (2002) Cell Res, 12, pp. 311-320; Jaiswal, M., Larusso, N., Burgart, L., Gores, G., Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism (2000) Cancer Res, 60 (1), pp. 184-190; Mocellin, S., Bronte, V., Nitti, D., Nitric oxide, a double edged sword in cancer biology: Searching for therapeutic opportunities (2007) Med Res Rev, 27, pp. 317-352; Thomsen, L.L., Nitric oxide synthase activity in human breast cancer (1995) Br J Cancer, 72, pp. 41-44; Reveneau, S., Nitric oxide synthase in human breast cancer is associated with tumor grade, proliferation rate, and expression of progesterone receptors (1999) Lab Investig, 79, pp. 1215-1225; Vakkala, M., Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas (2000) Clin Cancer Res, 6, pp. 2408-2416; Loibl, S., Expression of endothelial and inducible nitric oxide synthase in benign and malignant lesions of the breast and measurement of nitric oxide using electron paramagnetic resonance spectroscopy (2002) Cancer, 95, pp. 1191-1198; Nathan, C., Xie, Q.W., Nitric oxide synthases: Roles, tolls, and controls (1994) Cell, 78, pp. 915-918; Lim, K.-H., Ancrile, B.B., Kashatus, D.F., Counter, C.M., Tumour maintenance is mediated by eNOS (2008) Nature, 452, pp. 646-649; Martinez-Outschoorn, U.E., Sotgia, F., Lisanti, M.P., Caveolae and signalling in cancer (2015) Nat Rev Cancer, 15, pp. 225-237; Feron, O., Saldana, F., Michel, J.B., Michel, T., The endothelial nitric-oxide synthase-caveolin regulatory cycle (1998) J Biol Chem, 273, pp. 3125-3128; Cleeter, M.W.J., Cooper, J.M., Darley-Usmar, V.M., Moncada, S., Schapira, A.H.V., Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide (1994) FEBS Lett, 345, pp. 50-54; Martinez-Outschoorn, U.E., Lisanti, M.P., Sotgia, F., Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth (2014) Semin Cancer Biol, 25, pp. 47-60; Witkiewicz, A.K., An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers (2009) Am J Pathol, 174, pp. 2023-2034; Sloan, E.K., Stromal cell expression of caveolin-1 predicts outcome in breast cancer (2009) Am J Pathol, 174, pp. 2035-2043; Goetz, J.G., Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis (2011) Cell, 146, pp. 148-163; Ayala, G., Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression (2013) J Pathol, 231, pp. 77-87; Zhao, X., Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer (2013) Plos One, 8; Kim, Y.M., Bombeck, C.A., Billiar, T.R., Nitric oxide as a bifunctional regulator of apoptosis (1999) Circ Res, 84, pp. 253-256; Choi, B.-M., Pae, H.-O., Jang, S.I.I., Kim, Y.-M., Chung, H.-T., Nitric oxide as a pro-apoptotic as well as anti-apoptotic modulator endogenous NO production and NO donors (2002) J Biochem Mol Biol, 35, pp. 116-126; Genaro, A.M., Hortelano, S., Alvarez, A., Mart�nez, C., Bosc�, L., Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels (1995) J Clin Invest, 95, pp. 1884-1890; Li, J., Yang, S., Billiar, T.R., Cyclic nucleotides suppress tumor necrosis factor alpha-mediated apoptosis by inhibiting caspase activation and cytochrome c release in primary hepatocytes via a mechanism independent of Akt activation (2000) J Biol Chem, 275, pp. 13026-13034; Kim, Y., Nitric oxide prevents tumor necrosis factor ?�induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8 (2000) Hepatology, 32, pp. 770-778; Kim, Y.M., Talanian, R.V., Billiar, T.R., Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms (1997) J Biol Chem, 272, pp. 31138-31148; Ceneviva, G.D., Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells (1998) Am J Phys, 275, pp. L717-L728; Mannick, J.B., Asano, K., Izumi, K., Kieff, E., Stamler, J.S., Nitric oxide produced by human B lymphocytes inhibits apoptosis and epstein-barr virus reactivation (1994) Cell, 79, pp. 1137-1146; Hussain, A.R., Xiap over-expression is a poor prognostic marker in breast cancer and can be targeted to induce efficient apoptosis (2015) Cancer Res, 75; Ji, J., XIAP maintains the characteristics of cancer stem cells and is a therapeutic target in nasopharyngeal carcinoma (2015) Cancer Res, 75; Gu, L., Discovery of dual inhibitors of MDM2 and XIAP for cancer treatment (2016) Cancer Cell, 30, pp. 623-636; Yang, J., Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked (1997) Science, 275, pp. 1129-1132; Kim, Y.M., Chung, H.T., Simmons, R.L., Billiar, T.R., Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition (2000) J Biol Chem, 275, pp. 10954-10961; Li, H., Zhu, H., Cj, X., Yuan, J., Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis (1998) Cell, 94, pp. 491-501; Kim, Y.-M., Bergonia, H., Lancaster, J.R., Nitrogen oxide-induced autoprotection in isolated rat hepatocytes (1995) FEBS Lett, 374, pp. 228-232; Kim, Y.M., De Vera, M.E., Watkins, S.C., Billiar, T.R., Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression (1997) J Biol Chem, 272, pp. 1402-1411; Liu, D., Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (INOS-/-) (2000) Diabetes, 49, pp. 1116-1122; R�ssig, L., Nitric oxide down-regulates MKP-3 mRNA levels: Involvement in endothelial cell protection from apoptosis (2000) J Biol Chem, 275, pp. 25502-25507; Choudhari, S.K., Chaudhary, M., Bagde, S., Gadbail, A.R., Joshi, V., Nitric oxide and cancer: A review (2013) World J Surg Oncol, 11, p. 118; Ziche, M., Morbidelli, L., Nitric oxide and angiogenesis (2000) J Neuro-Oncol, 50, pp. 139-148; Jenkins, D.C., Roles of nitric oxide in tumor growth (1995) Proc Natl Acad Sci U S A, 92, pp. 4392-4396; Morbidelli, L., Donnini, S., Ziche, M., Role of nitric oxide in tumor angiogenesis (2004) Cancer Treat Res, 117, pp. 155-167; Gallo, O., Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer (1998) J Natl Cancer Inst, 90, pp. 587-596; Franchi, A., Inducible nitric oxide synthase expression in laryngeal neoplasia: Correlation with angiogenesis (2002) Head Neck, 24, pp. 16-23; Hoeben, A., Vascular endothelial growth factor and angiogenesis (2004) Pharmacol Rev, 56; Wiseman, H., Halliwell, B., Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer (1996) Biochem J, 313, pp. 17-29; Sappayatosok, K., Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in oral squamous cell carcinoma (OSCC), relationship with angiogenesis and their clinico-pathological correlation (2009) Med Oral Patol Oral Cir Bucal, 14, pp. E319-E324; Medeiros, R.M., Outcome in prostate cancer: Association with endothelial nitric oxide synthase Glu-Asp298 polymorphism at exon 7 (2002) Clin Cancer Res, 8, pp. 3433-3437; Ghilardi, G., Vascular invasion in human breast cancer is correlated to T-->786C polymorphism of NOS3 gene (2003) Nitric Oxide Biol Chem, 9, pp. 118-122; Tatemichi, M., Increased risk of intestinal type of gastric adenocarcinoma in Japanese women associated with long forms of CCTTT pentanucleo-tide repeat in the inducible nitric oxide synthase promoter (2005) Cancer Lett, 217, pp. 197-202; Marangoni, K., Ara�jo, T.G., Neves, A.F., Goulart, L.R., The -786T>C promoter polymorphism of the NOS3 gene is associated with prostate cancer progression (2008) BMC Cancer, 8, p. 273; Lee, K.-M., Nitric oxide synthase gene polymorphisms and prostate cancer risk (2009) Carcinogenesis, 30, pp. 621-625; Gao, X., Wang, J., Wang, W., Wang, M., Zhang, J., ENOS genetic polymorphisms and cancer risk a meta-analysis and a case�control study of breast cancer (2015) Medicine (Baltimore), 94, pp. 1-10; Jiao, J., Wu, J., Huang, D., Liu, L., Lack of association of the iNOS gene polymorphism with risk of cancer: A systematic review and Meta-Analysis (2015) Sci Rep, 5, p. 9889; Koppula, S., Kumar, H., Kim, I.S., Choi, D.-K., Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson�s disease (2012) Mediat Inflamm, 2012; God�nez-Rub�, M., Rojas-Mayorqu�n, A.E., Ortu�o-Sahag�n, D., Nitric oxide donors as neuroprotective agents after an ischemic stroke-related inflammatory reaction (2013) Oxidative Med Cell Longev, 2013; Atochin, D.N., A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia�reperfusion injury in mice (2016) Neurosci Lett, 618, pp. 45-49; Woodhouse, L., Effect of hyperacute administration (Within 6 hours) of transdermal glyc-eryl trinitrate, a nitric oxide donor, on outcome after stroke (2015) Stroke, 46, pp. 3194-3201; Hickok, J.R., Thomas, D.D., Nitric oxide and cancer therapy: The emperor has NO clothes (2010) Curr Pharm Des, 16, pp. 381-391; Kanayama, N., Yamaguchi, K., Nagasaki, Y., PEGylated polymer micelle-based nitric oxide (NO) photodonor with NO-mediated antitumor activity (2010) Chem Lett, 39, pp. 1008-1009; Kim, J., Yung, B.C., Kim, W.J., Chen, X., Combination of nitric oxide and drug delivery systems: Tools for overcoming drug resistance in chemotherapy (2016) J Control Release; Chakrapani, H., Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound (2008) Bioorg Med Chem, 16, pp. 2657-2664; Kiziltepe, T., JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells (2007) Blood, 110, pp. 709-718; Dong, R., Effects of JS-K, a novel anti-cancer nitric oxide prodrug, on gene expression in human hepatoma Hep3B cells (2017) Biomed Pharmacother, 88, pp. 367-373; Liu, J., Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells (2009) Genomics, 94, pp. 32-38; Hagos, G.K., Colon cancer chemopre-vention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo (2007) Mol Cancer Ther, 6, pp. 2230-2239; Gao, J., Liu, X., Rigas, B., Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress (2005) Proc Natl Acad Sci, 102, pp. 17207-17212; Aliev, G., Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overpro- liferation and deletion (2013) Oxidative Med Cell Longev, 2013; Stewart, B., Wild, C.P., (2014) International Agency for Research on Cancer, , W World Cancer Rep 2014; (2014) World Cancer Factsheet; Fidler, I., Timeline, J., The pathogenesis of cancer metastasis: The �seed and soil� hypothesis revisited (2003) Nat Rev Cancer, 3, pp. 453-458; Nishida, N., Yano, H., Nishida, T., Kamura, T., Kojiro, M., Angiogenesis in cancer (2006) Vasc Health Risk Manag, 2, pp. 213-219
dcterms.sourceScopus

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
avatar_scholar_128.png
Size:
2.73 KB
Format:
Portable Network Graphics
Description:
Download
Thumbnail Image
Name:
2017_Book_PersonalisedMedicine.pdf
Size:
10.29 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Faculty Of Pharmacy Research Paper