The role of nitric oxide from neurological disease to cancer

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Date

2017

Journal Title

Journal ISSN

Volume Title

Type

Book Chapter

Publisher

Springer New York LLC

Series Info

Advances in Experimental Medicine and Biology
1007

Abstract

Until the beginning of the 1980s, nitric oxide (NO) was just a toxic molecule of a lengthy list of environmental pollutants such as cigarette smoke and smog. In fact, NO had a very bad reputation of being destroyer of ozone, suspected carcinogen and precursor of acid rain. However, by the early 1990s it was well recognized by the medical research community. Over the last two decades, the picture has been totally changed. Diverse lines of evidence have converged to show that this sometime poison is a fundamental player in the everyday business of the human body. NO activity was probed in the brain, arteries, immune system, liver, pancreas, uterus, peripheral nerves, lungs, and almost every system in the human body. NO is a major player in the cardiovascular system as it is involved in regulating blood pressure. In the CNS, it is involved in memory formation and the regulation of cerebral blood flow to ensure adequate supply of blood to the brain. Because NO is involved in many pathways, it has a role in several diseases related to modern life as hypertension, coronary heart diseases, Alzheimer�s Disease, stroke and cancer. This chapter focuses on the discussion of the role of NO in neurological diseases and cancer and how can this Janus-faced molecule play a role in the pathology and personalized treatment of these diseases. � American Association of Pharmaceutical Scientists 2017.

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Scopus

Keywords

Cancer, CNS, Neurodegeneration disorders, Nitric oxide (NO), NO signal transduction, NO-targeted therapy, NOS expression, acetylsalicylic acid, antineoplastic agent, caspase, cyclic GMP, cyclin dependent kinase 5, dynamin related protein 1, enzyme inhibitor, glyceraldehyde 3 phosphate dehydrogenase, gt 094, guanosine triphosphatase, inducible nitric oxide synthase, myocyte enhancer factor 2, nitric oxide, nitric oxide donor, parkin, protein disulfide isomerase, protein p53, unclassified drug, X linked inhibitor of apoptosis, nitric oxide, Alzheimer disease, brain blood flow, cancer risk, carcinogenesis, cardiovascular system, caveola, cell death, cell level, cerebrovascular accident, cognition, disorders of mitochondrial functions, DNA polymorphism, drug activity, drug targeting, genotoxicity, human, malignant neoplasm, memory, metastasis, nerve cell plasticity, neurologic disease, neuroprotection, neurotoxicity, priority journal, protein misfolding, signal transduction, synthesis, tissue level, tumor suppressor gene, vascularization, animal, blood pressure, brain circulation, brain disease, metabolism, neoplasm, physiology, Animals, Blood Pressure, Brain Diseases, Cerebrovascular Circulation, Humans, Neoplasms, Nitric Oxide

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