Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAl-Olayan E.M.
dc.contributor.authorEl-Khadragy M.F.
dc.contributor.authorAlajmi R.A.
dc.contributor.authorOthman M.S.
dc.contributor.authorBauomy A.A.
dc.contributor.authorIbrahim S.R.
dc.contributor.authorAbdel Moneim A.E.
dc.contributor.otherKing Saud University
dc.contributor.otherDepartment of Zoology
dc.contributor.otherFaculty of Science
dc.contributor.otherRiyadh
dc.contributor.otherSaudi Arabia; University of Helwan
dc.contributor.otherDepartment of Zoology and Entomology
dc.contributor.otherFaculty of Science
dc.contributor.otherCairo
dc.contributor.otherEgypt; University of Hail
dc.contributor.otherFaculty of Preparatory year
dc.contributor.otherHail
dc.contributor.otherSaudi Arabia; October University for Modern Science and Arts (MSA)
dc.contributor.otherFaculty of Biotechnology
dc.contributor.otherGiza
dc.contributor.otherEgypt; Qassim University
dc.contributor.otherLaboratory Sciences Department
dc.contributor.otherCollege of Science and Arts
dc.contributor.otherAl-Rass
dc.contributor.otherSaudi Arabia; National Organization for Drug Control and Research (NODCAR)
dc.contributor.otherMolecular Drug Evaluation Department
dc.contributor.otherGiza
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:33Z
dc.date.available2020-01-09T20:41:33Z
dc.date.issued2016
dc.descriptionScopus
dc.description.abstractBackground: Schistosomiasis is a prevalent parasitic disease found predominantly in tropical and sub-tropical areas of the developing world, with the second highest socioeconomic and public health burden despite strenuous control efforts. In the present study, we aimed to investigate the ameliorative effects of Ceratonia siliqua pod extract (CPE) on liver fibrosis and oxidative stress in mice infected with Schistosoma mansoni. Methods: The schistosomal hepatopathologic mouse model was established by tail immersion with schistosomal cercaria. The extract was given daily for 10 days beginning 42 days post-infection. Liver samples were obtained from mice sacrificed 9 weeks after infection. Liver histopathological changes were observed with hematoxylin-eosin and Masson trichrome staining. Results: Typical schistosomal hepatopathologic changes were induced in the untreated mice. However, the oral administration of CPE was effective in reducing worm number and the egg load in the liver. This treatment also decreased granuloma size and collagen deposition by inhibiting tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Schistosomal infection induced oxidative stress by increasing lipid peroxidation (LPO) and nitrite/nitrate (nitric oxide; NO) production along with concomitant decreases in glutathione (GSH) and various antioxidant enzymes, including superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. However, treatment of mice with CPE at 300 or 600 mg/kg inhibited LPO and NO production, increased GSH content, and restored the activities of the antioxidant enzymes compared with untreated infected mice. Furthermore, treatment with CPE inhibited apoptosis, as indicated by the reduced Bax expression in hepatic tissue. Conclusion: These data indicated that extracts from Ceratonia siliqua pods may play an important role in combating schistosomal hepatopathology and may inhibit granuloma formation and liver fibrosis through down-regulation of TIMP-2 expression. 2016 The Author(s).en_US
dc.identifier.doihttps://doi.org/10.1186/s12906-016-1389-1
dc.identifier.doiPubMedID27821159
dc.identifier.issn14726882
dc.identifier.otherhttps://doi.org/10.1186/s12906-016-1389-1
dc.identifier.otherPubMedID27821159
dc.identifier.urihttps://t.ly/6xx8Z
dc.language.isoEnglishen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofseriesBMC Complementary and Alternative Medicine
dc.relation.ispartofseries16
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectCeratonia siliquaen_US
dc.subjectLiver fibrosisen_US
dc.subjectOxidative stressen_US
dc.subjectSchistosoma mansonien_US
dc.subjectTIMP-2en_US
dc.subjectalkaloid derivativeen_US
dc.subjectantiparasitic agenten_US
dc.subjectcatalaseen_US
dc.subjectCeratonia siliqua extracten_US
dc.subjectcinnamic acid derivativeen_US
dc.subjectcollagenen_US
dc.subjectgallic aciden_US
dc.subjectglutathioneen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectglutathione reductaseen_US
dc.subjectkaempferolen_US
dc.subjectnitrateen_US
dc.subjectnitric oxideen_US
dc.subjectnitriteen_US
dc.subjectpiceiden_US
dc.subjectplant extracten_US
dc.subjectpraziquantelen_US
dc.subjectprotein Baxen_US
dc.subjectquercitrinen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjecttannin derivativeen_US
dc.subjecttissue inhibitor of metalloproteinase 2en_US
dc.subjectunclassified drugen_US
dc.subjectantioxidanten_US
dc.subjectcatalaseen_US
dc.subjectglutathioneen_US
dc.subjectplant extracten_US
dc.subjectsuperoxide dismutaseen_US
dc.subjecttissue inhibitor of metalloproteinase 2en_US
dc.subjectanimal cellen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectbiosynthesisen_US
dc.subjectCeratonia siliquaen_US
dc.subjectcercariaen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug effecten_US
dc.subjectdrug efficacyen_US
dc.subjectenzyme activityen_US
dc.subjecthistopathologyen_US
dc.subjectlegumeen_US
dc.subjectlipid peroxidationen_US
dc.subjectliver fibrosisen_US
dc.subjectliver granulomaen_US
dc.subjectmaleen_US
dc.subjectmouseen_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectparasite identificationen_US
dc.subjectparasite loaden_US
dc.subjectprotein contenten_US
dc.subjectprotein expressionen_US
dc.subjectSchistosoma mansonien_US
dc.subjectschistosomiasis mansonien_US
dc.subjecttreatment durationen_US
dc.subjecttreatment responseen_US
dc.subjecttumor volumeen_US
dc.subjectanimalen_US
dc.subjectchemistryen_US
dc.subjectdrug effectsen_US
dc.subjectenzymologyen_US
dc.subjectFabaceaeen_US
dc.subjectgeneticsen_US
dc.subjecthumanen_US
dc.subjectliveren_US
dc.subjectliver cirrhosisen_US
dc.subjectmetabolismen_US
dc.subjectoxidative stressen_US
dc.subjectparasitologyen_US
dc.subjectphysiologyen_US
dc.subjectschistosomiasis mansonien_US
dc.subjectAnimalsen_US
dc.subjectAntioxidantsen_US
dc.subjectCatalaseen_US
dc.subjectFabaceaeen_US
dc.subjectGlutathioneen_US
dc.subjectHumansen_US
dc.subjectLipid Peroxidationen_US
dc.subjectLiveren_US
dc.subjectLiver Cirrhosisen_US
dc.subjectMaleen_US
dc.subjectMiceen_US
dc.subjectOxidative Stressen_US
dc.subjectPlant Extractsen_US
dc.subjectSchistosoma mansonien_US
dc.subjectSchistosomiasis mansonien_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectTissue Inhibitor of Metalloproteinase-2en_US
dc.titleCeratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stressen_US
dc.typeArticleen_US
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