Design, Sequential Synthesis, Kinase Inhibitors Comparative Docking, MD Simulations, 99mTc-Coupling and In-Vivo Studies of Novel Pyrazolopyrimidine Derivatives

dc.AffiliationOctober University for modern sciences and Arts MSA
dc.contributor.authorWafaa Zaghary
dc.contributor.authorDina Adel
dc.contributor.authorBasma M Essa
dc.contributor.authorTamer Nasr
dc.contributor.authorKhaled El-Adl
dc.contributor.authorTamer M Sakr
dc.date.accessioned2025-04-15T13:42:14Z
dc.date.available2025-04-15T13:42:14Z
dc.date.issued2025-04-10
dc.descriptionSJR 2024 0.269 Q3 H-Index 36
dc.description.abstractPyrazolopyrimidine derivative was synthesized and labeled with 99mTc using sodium dithionite as reducing agents. The purity of radiochemical 99mTc(Na2 S2O4 )-compound was 93.4%, and the synthesized complex was stable in vitro for 6 hours. Furthermore, using a radiolabeling technique, a bio-distribution investigation showed that tumor-bearing mice exhibited a remarkable absorption of [99mTc]Tc-complex, with a significant concentration in tumor tissues and a T/NT of 6.58 after 60 minutes after injection. These encouraging results mean that the synthesized compound offers a potential radio-carrier that can be used as a tumor marker and, following additional preclinical research, can be used for cancer therapy. Molecular dynamic simulation confirmed the stability of this compound in the active sites of both EGFR and VEGFR-2 receptors.
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=145358&tip=sid&clean=0
dc.identifier.citationZaghary, W. A., Adel, D., Mohamed, B., Nasr, T., El-Adl, K., & Sakr, T. M. (2024). Design, sequential synthesis, kinase inhibitors comparative docking, MD simulations, 99mTc-coupling and in-vivo studies of novel pyrazolopyrimidine derivatives. Egyptian Journal of Chemistry, 0(0), 0. https://doi.org/10.21608/ejchem.2024.302958.9979
dc.identifier.doihttps://doi.org/10.21608/ejchem.2024.302958.9979
dc.identifier.otherhttps://doi.org/10.21608/ejchem.2024.302958.9979
dc.identifier.urihttps://repository.msa.edu.eg/handle/123456789/6380
dc.language.isoen_US
dc.publisherNational Information and Documentation Center (NIDOC)
dc.relation.ispartofseriesEgyptian Journal of Chemistry ; Volume 68, Issue 4, Pages 267 - 280 , April 2025
dc.subjectPyrazolopyrimidines
dc.subjectComparative docking
dc.subjectKinase inhibitors
dc.subject99mTc-coupling
dc.subjectTumor imaging
dc.subjectMD simulation
dc.titleDesign, Sequential Synthesis, Kinase Inhibitors Comparative Docking, MD Simulations, 99mTc-Coupling and In-Vivo Studies of Novel Pyrazolopyrimidine Derivatives
dc.typeArticle

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