Conductomtric Determination of Torasemide in Bulk Drug, in Formulations and in Plasma

Abstract

Two simple and sensitive conductometric procedures were investigated for the determination of torasemide (TOS) using potasium tetraphenyl borate (K TPB) and ammonium reineckate (Amm. RNC) were described. Optimized conditions including temperature, solvent and reagent concentration were studied. The suggested methods were used for conductometric determination of (TOS) in its pharmaceutical preparations. Precision, measured as relative standard deviation was less than 1% and accuracy was 99.76%.The obtained results were comparable with data using the reported method. The proposed procedures were successfully adapted for the determination of (TOS) in plasma. For comparison, some interference was also determined by the condutometric titrations. At equimolar concentration levels, some molecules of similar structure interfere with the original drug. A reduction in interferent concentration by a factor of 10 negated the interference.