IL-10 and TGF-?: Roles in chondroprotective effects of Glucosamine in experimental Osteoarthritis?
| dc.Affiliation | October University for modern sciences and Arts (MSA) | |
| dc.contributor.author | Waly N.E. | |
| dc.contributor.author | Refaiy A. | |
| dc.contributor.author | Aborehab N.M. | |
| dc.contributor.other | Department of Physiology | |
| dc.contributor.other | Faculty of Medicine | |
| dc.contributor.other | Helwan University | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | 11795 | |
| dc.contributor.other | Egypt; Department of Pathology Faculty of Medicine | |
| dc.contributor.other | Assiut University | |
| dc.contributor.other | Assiut | |
| dc.contributor.other | 71515 | |
| dc.contributor.other | Egypt; Department of Biochemistry | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | MSA University | |
| dc.contributor.other | Giza | |
| dc.contributor.other | 11787 | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:41:22Z | |
| dc.date.available | 2020-01-09T20:41:22Z | |
| dc.date.issued | 2017 | |
| dc.description | Scopus | |
| dc.description.abstract | Objective Osteoarthritis (OA) is a complex disease of the whole joint. Glucosamine (GlcN) treatment may have a chondroprotective effect on OA. We investigated the mechanism of action of glucosamine treatment through interleukin-10 (Il-10) and transforming growth factor ?-1 (TGF ?-1). Methods Thirty male albino rats were used. A single intraarticular (i.a.) injection of 2�mg of Monosodium Iodoacetate (MIA) was injected into the knee joint of anesthetized rats. GlcN (50 or 100�mg/kg/day, p.o. for 2 month) was administered orally. Serum levels of Il-10 and TGF-?1 were determined by ELISA. Histopathological changes in treated and control joints were examined using hematoxylin-eosin (H & E) staining. Results The mean serum level of IL-10 significantly decreased in the OA group compared to control group (P value�<�0.0001). On the other hand, mean serum level of IL-10 significantly increased in GlcN treated groups when compared to the OA group (P value�<�0.0001). Serum level of TGF ?-1 was significantly elevated in OA group compared to control group (P value�<�0.0001). On the other hand, the mean serum level of TGF ?-1 was significantly decreased in the GlcN treated groups when compared to the OA group (P value�<�0.0001). Histopathological evaluation of GlcN treated groups showed different grades of healing, according to Osteoarthritis Research Society International (OARSI) grading system. Conclusion Our results showed that IL-10 and TGF-?1 possibly mediate GlcN chondroprotective effects in OA. Both serum biomarkers can be useful in the follow-up of articular cartilage damage in clinical settings. � 2017 Elsevier B.V. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=24001&tip=sid&clean=0 | |
| dc.identifier.doi | https://doi.org/10.1016/j.pathophys.2017.02.005 | |
| dc.identifier.doi | PubMed ID : | |
| dc.identifier.issn | 9284680 | |
| dc.identifier.other | https://doi.org/10.1016/j.pathophys.2017.02.005 | |
| dc.identifier.other | PubMed ID : | |
| dc.identifier.uri | https://t.ly/kN7n3 | |
| dc.language.iso | English | en_US |
| dc.publisher | Elsevier B.V. | en_US |
| dc.relation.ispartofseries | Pathophysiology | |
| dc.relation.ispartofseries | 24 | |
| dc.subject | Glucosamine | en_US |
| dc.subject | IL-10�TGF-? | en_US |
| dc.subject | Osteoarthritis | en_US |
| dc.subject | biological marker | en_US |
| dc.subject | glucosamine | en_US |
| dc.subject | interleukin 10 | en_US |
| dc.subject | transforming growth factor beta | en_US |
| dc.subject | animal experiment | en_US |
| dc.subject | animal model | en_US |
| dc.subject | Article | en_US |
| dc.subject | chondroprotection | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | drug mechanism | en_US |
| dc.subject | enzyme linked immunosorbent assay | en_US |
| dc.subject | experimental osteoarthritis | en_US |
| dc.subject | healing | en_US |
| dc.subject | histopathology | en_US |
| dc.subject | male | en_US |
| dc.subject | nonhuman | en_US |
| dc.subject | protein blood level | en_US |
| dc.subject | rat | en_US |
| dc.title | IL-10 and TGF-?: Roles in chondroprotective effects of Glucosamine in experimental Osteoarthritis? | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus |