Ion-Selective membrane sensors for the determination of ciprofloxacin hydrochloride in water and pharmaceutical formulation

Abstract

The construction and electrochemical response characteristics of six Ciprofloxacin-selective electrodes were investigated using precipitation based technique with sodium tetraphenyl borate (TPB), phosphomolybdate (PMA) and phosphotungstate (PTA); respectively upon using polyvinyl chloride (PVC) matrix and dibutyl phthalate (DBP) as a plasticizer. The resultant sensors have different forms, either as membrane electrodes (sensors 1, 3 and 5) or as coated wire electrodes (sensors 2, 4 and 6). Linear responses of CIP within the concentration ranges of 10?6 to 10?2 mol/L for sensors 1, 2 and 5 while for sensors 3 and 4, the linear responses were within the concentration ranges of 10?5 to 10?2 mol/L and for sensor 6 it shows linear responses within the concentration ranges of 10?7 to 10?2 mol/L. Nernstian slopes of 51.7, 50.7, 58.3, 57.7, 44 and 41.8 mV/decade were observed over the pH range of (5�9) for sensors 1, 2, 5 and 6 and over range of (5-7) for sensor 3 and 4 respectively. The selectivity coefficients of the developed sensors indicated excellent selectivity for CIP. The proposed sensors displayed useful analytical characteristics for the determination of CIP in water samples and pharmaceutical preparation. 2014 by CEE.