Formulation and bioavaliability study of bioadhesive gastroretentive tablets of captopril
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Date
2015
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Article
Publisher
Indian Stream Research Journal
Series Info
Indian Stream Research Journal;Volume: 5 Issue: 10
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Abstract
The present study concerns the development of bioadhesive tablets of Captopril which were designed to prolong the gastric residence time after oral administration. Captopril is an angiotensin converting enzyme inhibitor; it has been widely used for the treatment of hypertension and congestive heart failure. Tablets of Captopril were prepared by direct compression method using bioadhesive polymers like Carbopol 934P, PVP K90 and CMC-Na in different ratios.
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University of Captopril
Citation
Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Amini M, Zarghi A, Vatanpour H. 1999. Sensitive highperformance liquid chromatographic method for determination of captopril in plasma. Pharm ActaHelv.,73: 303 – 6. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. Ali J, Khar R, Ahuja A, Karla R. 2002. Buccoadhesive erodible disk for treatment of orodental infections design and characterization. Int. J. Pharm, 283: 93‐103. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709. Batchelor H. 2004. Novel bioadhesive formulations in drug delivery, Presented in at the British pharmaceutical conference on drug delivery to the upper GI tract, particularly the esophagus: Medicinal Research Unit, Aston University, Birmingham, B47ET, UK. AgaiahGoudet al.2011. Formulation and Evaluation of Bioadhesivebuccal tablets of Simvastatin. J of Adv Pharm Sciences, 1(1): 29-38. Agarwal, V. and B. Mishra, 1999. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Dev. Ind. Pharm., 25(6): 701-709.