Synthesis and in vitro antitumor activity of some new Mannich bases

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorKandeel M.M.
dc.contributor.authorAbdou N.A.
dc.contributor.authorKadry H.H.
dc.contributor.authorEl-Masry R.M.
dc.contributor.otherPharmaceutical Organic Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Organic Chemistry Department
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.other6 October City
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:42:29Z
dc.date.available2020-01-09T20:42:29Z
dc.date.issued2013
dc.descriptionScopus
dc.description.abstractTwo series of Novel Mannich bases has been synthesized from chalcones 3 and 7 and evaluated for their in vitro cytotoxic activity. Out of the newly synthesized compounds, four derivatives 4a, 4b, 4e, 4f were selected by the National Cancer Institute (NCI) to be evaluated for their in-vitro antitumor activity by in-vitro disease-oriented human cells screening panel assay. All the tested compounds exhibited a broad spectrum of antitumor activity against renal cancer UO-31.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=19700175055&tip=sid&clean=0
dc.identifier.doihttps://doi.org/
dc.identifier.issn9744290
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://t.ly/2dwYb
dc.language.isoEnglishen_US
dc.relation.ispartofseriesInternational Journal of ChemTech Research
dc.relation.ispartofseries5
dc.subjectAntitumor activityen_US
dc.subjectChalconesen_US
dc.subjectCytotoxicityen_US
dc.subjectMannich basesen_US
dc.subjectSynthesisen_US
dc.subjectantineoplastic agenten_US
dc.subjectchalcone derivativeen_US
dc.subjectMannich baseen_US
dc.subjectantineoplastic activityen_US
dc.subjectarticleen_US
dc.subjectcell counten_US
dc.subjectcolon canceren_US
dc.subjectcontrolled studyen_US
dc.subjectcytotoxicityen_US
dc.subjectdrug synthesisen_US
dc.subjectgrowth inhibitionen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectinfrared spectrophotometryen_US
dc.subjectkidney canceren_US
dc.subjectmass fragmentographyen_US
dc.subjectmelting pointen_US
dc.subjectmicroanalysisen_US
dc.subjectproton nuclear magnetic resonanceen_US
dc.subjectthin layer chromatographyen_US
dc.titleSynthesis and in vitro antitumor activity of some new Mannich basesen_US
dc.typeArticleen_US
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