Synthesis and in vitro antitumor activity of some new Mannich bases
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International Journal of ChemTech Research
5
5
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Abstract
Two series of Novel Mannich bases has been synthesized from chalcones 3 and 7 and evaluated for their in vitro cytotoxic activity. Out of the newly synthesized compounds, four derivatives 4a, 4b, 4e, 4f were selected by the National Cancer Institute (NCI) to be evaluated for their in-vitro antitumor activity by in-vitro disease-oriented human cells screening panel assay. All the tested compounds exhibited a broad spectrum of antitumor activity against renal cancer UO-31.
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Keywords
Antitumor activity, Chalcones, Cytotoxicity, Mannich bases, Synthesis, antineoplastic agent, chalcone derivative, Mannich base, antineoplastic activity, article, cell count, colon cancer, controlled study, cytotoxicity, drug synthesis, growth inhibition, human, human cell, infrared spectrophotometry, kidney cancer, mass fragmentography, melting point, microanalysis, proton nuclear magnetic resonance, thin layer chromatography