The reaction of cyclohexan-1,3-dione with cyanomethylenes: Synthesis of thiophenes and their fused derivatives with antifungal activities

Abstract

2-Amino-7-oxotetrahydrobenzo[b]thiophenes 3a,b were prepared according to the Gewald procedure. Their reactivity toward a variety of chemical reagents was studied to give annulated heterocycles with potential bio-responses.