Preclinical models of breast cancer: Two-way shuttles for immune checkpoint inhibitors from and to patient bedside

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAbdel-Aziz A.K.
dc.contributor.authorSaadeldin M.K.
dc.contributor.authorD'Amico P.
dc.contributor.authorOrecchioni S.
dc.contributor.authorBertolini F.
dc.contributor.authorCurigliano G.
dc.contributor.authorMinucci S.
dc.contributor.otherDepartment of Experimental Oncology
dc.contributor.otherIEO
dc.contributor.otherEuropean Institute of Oncology IRCCS
dc.contributor.otherMilan
dc.contributor.otherItaly; Department of Pharmacology and Toxicology
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAin Shams University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Faculty of Biotechnology
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.other6th October City
dc.contributor.otherCairo
dc.contributor.otherEgypt; Division of Early Drug Development for Innovative Therapies
dc.contributor.otherIEO
dc.contributor.otherEuropean Institute of Oncology IRCCS
dc.contributor.otherMilan
dc.contributor.otherItaly; Laboratory of Hematology-Oncology
dc.contributor.otherIEO
dc.contributor.otherEuropean Institute of Oncology IRCCS
dc.contributor.otherMilan
dc.contributor.otherItaly; Department of Oncology and Hemato-Oncology
dc.contributor.otherUniversity of Milano
dc.contributor.otherMilan
dc.contributor.otherItaly; Department of Biosciences
dc.contributor.otherUniversity of Milan
dc.contributor.otherMilan
dc.contributor.otherItaly
dc.date.accessioned2020-01-09T20:40:31Z
dc.date.available2020-01-09T20:40:31Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractThe Food and Drug Administration has lately approved atezolizumab, anti-programmed death ligand 1 (PD-L1), to be used together with nanoparticle albumin-bound (nab) paclitaxel in treating patients with triple negative breast cancer (BC) expressing PD-L1. Nonetheless, immune checkpoint inhibitors (ICIs) are still challenged by the resistance and immune-related adverse effects evident in a considerable subset of treated patients without conclusive comprehension of the underlying molecular basis, biomarkers and tolerable therapeutic regimens capable of unleashing the anti-tumour immune responses. Stepping back to preclinical models is thus inevitable to address these inquiries. Herein, we comprehensively review diverse preclinical models of BC exploited in investigating ICIs underscoring their pros and cons as well as the learnt and awaited lessons to allow full exploitation of ICIs in BC therapy. 2019 Elsevier Ltden_US
dc.identifier.doihttps://doi.org/10.1016/j.ejca.2019.08.013
dc.identifier.doiPubMedID31606656
dc.identifier.issn9598049
dc.identifier.otherhttps://doi.org/10.1016/j.ejca.2019.08.013
dc.identifier.otherPubMedID31606656
dc.identifier.urihttps://t.ly/0E76g
dc.language.isoEnglishen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofseriesEuropean Journal of Cancer
dc.relation.ispartofseries122
dc.subjectBreast canceren_US
dc.subjectCTLA-4en_US
dc.subjectImmune checkpoint inhibitoren_US
dc.subjectPD-1en_US
dc.subjectPD-L1en_US
dc.subjectPreclinical modelen_US
dc.subjectantineoplastic agenten_US
dc.subjectbiological markeren_US
dc.subjectimmune checkpoint inhibitoren_US
dc.subjectimmunological antineoplastic agenten_US
dc.subjectnicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitoren_US
dc.subjectunclassified drugen_US
dc.subjectadjuvant therapyen_US
dc.subjectbreast canceren_US
dc.subjectcancer adjuvant therapyen_US
dc.subjectcancer chemotherapyen_US
dc.subjectcancer immunotherapyen_US
dc.subjectcancer modelen_US
dc.subjectcancer resistanceen_US
dc.subjectcancer transplantationen_US
dc.subjectcombination drug therapyen_US
dc.subjectex vivo studyen_US
dc.subjectexperimental designen_US
dc.subjecthumanen_US
dc.subjectimmune responseen_US
dc.subjectin vivo studyen_US
dc.subjectmolecular biologyen_US
dc.subjectmouse modelen_US
dc.subjectmurine modelen_US
dc.subjectmutational loaden_US
dc.subjectneoadjuvant therapyen_US
dc.subjectnonhumanen_US
dc.subjectpractice guidelineen_US
dc.subjectpreclinical studyen_US
dc.subjectpriority journalen_US
dc.subjectReviewen_US
dc.subjecttransgenic animalen_US
dc.subjecttumor immunityen_US
dc.subjecttumor vascularizationen_US
dc.subjecttumor volumeen_US
dc.titlePreclinical models of breast cancer: Two-way shuttles for immune checkpoint inhibitors from and to patient bedsideen_US
dc.typeReviewen_US
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