Application of molecular imprinting approach for alkaloids analysis in food and nutraceuticals: review and perspective
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Date
2023-10
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Springer Netherlands
Series Info
Phytochem Rev;
Scientific Journal Rankings
Abstract
Alkaloids are major dietary components
well known for their pharmacological activities.
Herbal matrices require extensive processing due to
their high level of complexity in order to isolate their
alkaloidal contents. Molecularly imprinted polymers
(MIPs) are tailored receptors with a highly specific
molecular recognition, which is the most important
function of receptors. They can hence be utilized in
applications wherein selective binding activities are of
significance, such as solid phase extraction (SPE),
chromatographic separation and chemical sensors.
This review presents on recent applications of MIPs to
analyze alkaloids in plants and bio-fluid samples as
well as herbal formulations. We discuss the develop-
ment of nano-sized MIPs for various applications,
particularly in biomimetic sensors for electrochemical
detection of various alkaloids. Due to its easier phase
separation compared to common MISPEs, magnetic
MISPEs were also discussed in order to explore the
potential benefits of this approach for further phyto-
chemical applications.
Description
Keywords
Molecularly imprinted polymers - Alkaloids - Solid phase extraction - Sensors - Sample preparation