Validated HPLC Method for Simultaneous Determination of Aripiprazole and Co-Administered Clonazepam in Spiked Human Plasma
| dc.Affiliation | October University for modern sciences and Arts (MSA) | |
| dc.contributor.author | M. El-Maraghy, Christine | |
| dc.contributor.author | Salem, Hesham | |
| dc.contributor.author | M. Amer, Sawsan | |
| dc.contributor.author | Nebsen, Marianne | |
| dc.date.accessioned | 2019-10-26T09:50:46Z | |
| dc.date.available | 2019-10-26T09:50:46Z | |
| dc.date.issued | 2017 | |
| dc.description | MSA Google Scholar | |
| dc.description.abstract | A sensitive and selective high performance liquid chromatographic method was developed and validated for the simultaneous quantification of Aripiprazole and co-administered Clonazepam in spiked human plasma. Aripiprazole, Clonazepam and the internal standard Citalopram were extracted from plasma and analyzed on a reversed-phase C18 column using a mobile phase consisting of acetonitrile and 0.05M potassium dihydrogen orthophosphate (pH= 3.6) in a ratio of (40: 60, v/v). The ultraviolet (UV) detection was at 220 nm. The method was linear over concentration range (20- 1000 ng mL-1 ) for both drugs. The method is very simple and allows obtaining a very good recovery of the analytes. | en_US |
| dc.description.sponsorship | Journal of Pharmaceutical and Applied Chemistry An International Journal | en_US |
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| dc.identifier.doi | https://doi.org/10.18576/jpac/030108 | |
| dc.identifier.other | https://doi.org/10.18576/jpac/030108 | |
| dc.identifier.uri | https://t.ly/xNwJq | |
| dc.language.iso | en | en_US |
| dc.publisher | Journal of Pharmaceutical and Applied Chemistry An International Journal | en_US |
| dc.relation.ispartofseries | J. Pharm. Appl. Chem;3, 1, 57-61 | |
| dc.subject | University of Aripiprazole | en_US |
| dc.subject | Clonazepam | en_US |
| dc.title | Validated HPLC Method for Simultaneous Determination of Aripiprazole and Co-Administered Clonazepam in Spiked Human Plasma | en_US |
| dc.type | Article | en_US |