Validated HPLC Method for Simultaneous Determination of Aripiprazole and Co-Administered Clonazepam in Spiked Human Plasma
Date
2017
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Journal of Pharmaceutical and Applied Chemistry An International Journal
Series Info
J. Pharm. Appl. Chem;3, 1, 57-61
Scientific Journal Rankings
Abstract
A sensitive and selective high performance liquid chromatographic method was developed and validated for the
simultaneous quantification of Aripiprazole and co-administered Clonazepam in spiked human plasma. Aripiprazole,
Clonazepam and the internal standard Citalopram were extracted from plasma and analyzed on a reversed-phase C18
column using a mobile phase consisting of acetonitrile and 0.05M potassium dihydrogen orthophosphate (pH= 3.6) in a
ratio of (40: 60, v/v). The ultraviolet (UV) detection was at 220 nm. The method was linear over concentration range (20-
1000 ng mL-1
) for both drugs. The method is very simple and allows obtaining a very good recovery of the analytes.
Description
MSA Google Scholar
Keywords
University of Aripiprazole, Clonazepam
Citation
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