A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAborehab N.M.
dc.contributor.authorEl Bishbishy M.H.
dc.contributor.authorRefaiy A.
dc.contributor.authorWaly N.E.
dc.contributor.otherMSA University
dc.contributor.otherDepartment of Biochemistry
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherGiza
dc.contributor.other11787
dc.contributor.otherEgypt; MSA University
dc.contributor.otherDepartment of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherGiza
dc.contributor.other11787
dc.contributor.otherEgypt; Assiut University
dc.contributor.otherDepartment of Pathology Faculty of Medicine
dc.contributor.otherAssiut
dc.contributor.other71515
dc.contributor.otherEgypt; Department of Physiology
dc.contributor.otherFaculty of Medicine
dc.contributor.otherHelwan University
dc.contributor.otherCairo
dc.contributor.other11795
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:13Z
dc.date.available2020-01-09T20:41:13Z
dc.date.issued2017
dc.descriptionScopus
dc.description.abstractBackground: Herbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in rat model. Methods: Thirty-five albino rats were intra-articularly injected with Monosodium Iodoacetate in the knee joint. Ginger and curcumin was orally administered at doses of 200 and 400mg/kg (F200 and F400). Serum levels of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), myeloperoxidase (MPO), Interleukin-1 beta (IL-1?) and superoxide dismutase activity (SOD) were measured using ELISA. The composition of the herbal formula hydro-ethanolic extract was characterized using UPLC-ESI-MS. Histopathological changes in injected joints was examined using routine histopathology. Statistical analysis was performed using one-way ANOVA. Results: Serum levels of COMP, HA, MPO, MDA, and IL-1? were significantly decreased in F 200, F 400 and V groups when compared to OA group (P value <0.0001). On the other hand SOD levels were significantly elevated in treated groups compared to OA groups (P value <0.0001). Conclusions: The ginger/curcumin at 1:1 had chondroprotective effect via anti-inflammatory and antioxidant effect in rat OA model. Further pharmacological and clinical studies are needed to evaluate this effect. � 2017 The Author(s).en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=34441&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1186/s12906-017-2002-y
dc.identifier.doiPubMed ID 29166937
dc.identifier.issn14726882
dc.identifier.otherhttps://doi.org/10.1186/s12906-017-2002-y
dc.identifier.otherPubMed ID 29166937
dc.identifier.urihttps://t.ly/6xMX1
dc.language.isoEnglishen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofseriesBMC Complementary and Alternative Medicine
dc.relation.ispartofseries17
dc.subjectCOMPen_US
dc.subjectCurcuminen_US
dc.subjectGingeren_US
dc.subjectHAen_US
dc.subjectIL-1?en_US
dc.subjectMDAen_US
dc.subjectMPOen_US
dc.subjectOsteoarthritisen_US
dc.subjectalcoholen_US
dc.subjectcartilage oligomeric matrix proteinen_US
dc.subjectcurcuminen_US
dc.subjectginger extracten_US
dc.subjecthyaluronic aciden_US
dc.subjectinterleukin 1betaen_US
dc.subjectiodoacetic aciden_US
dc.subjectmalonaldehydeen_US
dc.subjectmyeloperoxidaseen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectcartilage oligomeric matrix proteinen_US
dc.subjectcurcuminen_US
dc.subjecthyaluronic aciden_US
dc.subjectinterleukin 1betaen_US
dc.subjectmalonaldehydeen_US
dc.subjectperoxidaseen_US
dc.subjectplant extracten_US
dc.subjectprotective agenten_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantiinflammatory activityen_US
dc.subjectantioxidant activityen_US
dc.subjectArticleen_US
dc.subjectchondroprotectionen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug effecten_US
dc.subjectdrug mechanismen_US
dc.subjectEgypten_US
dc.subjectenzyme activityen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjecthistopathologyen_US
dc.subjectliquid chromatography-mass spectrometryen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectosteoarthritisen_US
dc.subjectprotein blood levelen_US
dc.subjectrandomized controlled trialen_US
dc.subjectraten_US
dc.subjectanimalen_US
dc.subjectblooden_US
dc.subjectchemistryen_US
dc.subjectdisease modelen_US
dc.subjectgingeren_US
dc.subjectmetabolismen_US
dc.subjectAnimalsen_US
dc.subjectCartilage Oligomeric Matrix Proteinen_US
dc.subjectCurcuminen_US
dc.subjectDisease Models, Animalen_US
dc.subjectGingeren_US
dc.subjectHyaluronic Aciden_US
dc.subjectInterleukin-1betaen_US
dc.subjectMaleen_US
dc.subjectMalondialdehydeen_US
dc.subjectOsteoarthritisen_US
dc.subjectPeroxidaseen_US
dc.subjectPlant Extractsen_US
dc.subjectProtective Agentsen_US
dc.subjectSuperoxide Dismutaseen_US
dc.titleA putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritisen_US
dc.typeArticleen_US
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