A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

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Date

2017

Journal Title

Journal ISSN

Volume Title

Type

Article

Publisher

BioMed Central Ltd.

Series Info

BMC Complementary and Alternative Medicine
17

Abstract

Background: Herbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in rat model. Methods: Thirty-five albino rats were intra-articularly injected with Monosodium Iodoacetate in the knee joint. Ginger and curcumin was orally administered at doses of 200 and 400mg/kg (F200 and F400). Serum levels of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), myeloperoxidase (MPO), Interleukin-1 beta (IL-1?) and superoxide dismutase activity (SOD) were measured using ELISA. The composition of the herbal formula hydro-ethanolic extract was characterized using UPLC-ESI-MS. Histopathological changes in injected joints was examined using routine histopathology. Statistical analysis was performed using one-way ANOVA. Results: Serum levels of COMP, HA, MPO, MDA, and IL-1? were significantly decreased in F 200, F 400 and V groups when compared to OA group (P value <0.0001). On the other hand SOD levels were significantly elevated in treated groups compared to OA groups (P value <0.0001). Conclusions: The ginger/curcumin at 1:1 had chondroprotective effect via anti-inflammatory and antioxidant effect in rat OA model. Further pharmacological and clinical studies are needed to evaluate this effect. � 2017 The Author(s).

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Scopus

Keywords

COMP, Curcumin, Ginger, HA, IL-1?, MDA, MPO, Osteoarthritis, alcohol, cartilage oligomeric matrix protein, curcumin, ginger extract, hyaluronic acid, interleukin 1beta, iodoacetic acid, malonaldehyde, myeloperoxidase, superoxide dismutase, cartilage oligomeric matrix protein, curcumin, hyaluronic acid, interleukin 1beta, malonaldehyde, peroxidase, plant extract, protective agent, superoxide dismutase, animal experiment, animal model, animal tissue, antiinflammatory activity, antioxidant activity, Article, chondroprotection, controlled study, drug effect, drug mechanism, Egypt, enzyme activity, enzyme linked immunosorbent assay, histopathology, liquid chromatography-mass spectrometry, male, nonhuman, osteoarthritis, protein blood level, randomized controlled trial, rat, animal, blood, chemistry, disease model, ginger, metabolism, Animals, Cartilage Oligomeric Matrix Protein, Curcumin, Disease Models, Animal, Ginger, Hyaluronic Acid, Interleukin-1beta, Male, Malondialdehyde, Osteoarthritis, Peroxidase, Plant Extracts, Protective Agents, Superoxide Dismutase

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