Synthesis and antimicrobial activity of 2-substituted-3-acetyl thiazolidine -4-carbonyl-amino acid derivatives

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Sharkawy K.A.
dc.contributor.otherOrganic Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (M.S.A)
dc.contributor.otherEl-Wahat road
dc.contributor.other6 October City
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:31Z
dc.date.available2020-01-25T19:58:31Z
dc.date.issued2011
dc.descriptionScopus
dc.description.abstractThe synthesis of different 2-substituted-3-acetyl-thiazolidine-4-carbonyl amino acid methyl esters (3-11) by coupling 2-substituted-3-acetyl-thiazolidine-4-carboxylic acid with amino acid methyl ester hydrochloride, corresponding amino acid hydrazides (12-20) via hydrazinolysis using hydrazine hydrate and 2-substituted- 3-acetyl-thiazolidine-4-carbonyl-N-benzylidine glycine hydrazone derivatives (21-26) were prepared via the condensation reaction of 2-substituted-3-acetyl-thiazolidine-4-carbonyl amino acid hydrazides with benzaldehyde and 4-chlorobenzaldehyde. The structures of the synthesized compounds were established by IR, 1H-NMR and MS data and elemental analysis results. The synthesized compounds were tested against different types of microorganism included gram-positive, gram-negative microorganisms Bacillius subtilis, Bacillus pumilus, Pesudomonas aeruginosa and Escherichia coli and the fungi Candida utilis. Some of the synthesized compounds were found to possess antimicrobial activities towards different type of microorganisms.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=19700174933&tip=sid&clean=0
dc.identifier.doihttps://doi.org/
dc.identifier.issn9751459
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://t.ly/W5eP7
dc.language.isoEnglishen_US
dc.relation.ispartofseriesJournal of Pharmaceutical Sciences and Research
dc.relation.ispartofseries3
dc.subjectAmino acid derivativesen_US
dc.subjectAntimicrobialen_US
dc.subjectThiazolidineen_US
dc.subject2 acetyl 2 methylthiazolidine 4 carbonyl glycine methyl esteren_US
dc.subject2 substituted 3 acetylthiazolidine 4 carbonyl amino methyl esteren_US
dc.subject2 substituted 3 acetylthiazolidine 4 carboxylic acid derivativeen_US
dc.subject2 substituted thiazolidine 4 carboxylic acid derivativeen_US
dc.subject3 acetyl 2 methylthiazolidine 4 carbonyl alanine hydrazideen_US
dc.subject3 acetyl 2 methylthiazolidine 4 carbonyl alanine methyl esteren_US
dc.subject3 acetyl 2 methylthiazolidine 4 carbonyl glycine hydrazideen_US
dc.subject3 acetyl 2 methylthiazolidine 4 carbonyl methionine hydrazideen_US
dc.subject3 acetyl 2 methylthiazolidine 4 carbonyl methionine methyl esteren_US
dc.subject3 acetyl 2 methylthiazolidine 4 carbonyl n 4 chlorobenzylidine glycine hydrazoneen_US
dc.subject3 acetyl 2 methylthiazolidine 4 carbonyl n benzylidine glycine hydrazoneen_US
dc.subject3 acetyl 2 phenylthiazolidine 4 carbonyl alanine hydrazideen_US
dc.subject3 acetyl 2 phenylthiazolidine 4 carbonyl alanine methyl esteren_US
dc.subject3 acetyl 2 phenylthiazolidine 4 carbonyl glycine hydrazideen_US
dc.subject3 acetyl 2 phenylthiazolidine 4 carbonyl glycine methyl esteren_US
dc.subject3 acetyl 2 phenylthiazolidine 4 carbonyl methionine hydrazideen_US
dc.subject3 acetyl 2 phenylthiazolidine 4 carbonyl methionine methyl esteren_US
dc.subject3 acetyl 2 phenylthiazolidine 4 carbonyl n 4' chlorobenzylidine glycine hydrazoneen_US
dc.subject3 acetyl 2 phenylthiazolidine 4 carbonyl n benzylidine glycine hydrazoneen_US
dc.subject3 acetyl 2,2 dimethylthiazolidine 4 carbonyl alanine hydrazideen_US
dc.subject3 acetyl 2,2 dimethylthiazolidine 4 carbonyl alanine methyl esteren_US
dc.subject3 acetyl 2,2 dimethylthiazolidine 4 carbonyl glycine hydrazideen_US
dc.subject3 acetyl 2,2 dimethylthiazolidine 4 carbonyl glycine methyl esteren_US
dc.subject3 acetyl 2,2 dimethylthiazolidine 4 carbonyl methionine hydrazideen_US
dc.subject3 acetyl 2,2 dimethylthiazolidine 4 carbonyl methionine methyl esteren_US
dc.subject3 acetyl 2,2 dimethylthiazolidine 4 carbonyl n 4' chlorobenzylidine glycine hydrazoneen_US
dc.subject3 acetyl 2,2 dimethylthiazolidine 4 carbonyl n benzylidine glycine hydrazoneen_US
dc.subjectamino acid derivativeen_US
dc.subjectsulfadimidineen_US
dc.subjectunclassified drugen_US
dc.subjectunindexed drugen_US
dc.subjectantimicrobial activityen_US
dc.subjectarticleen_US
dc.subjectBacillus pumilusen_US
dc.subjectBacillus subtilisen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug structureen_US
dc.subjectdrug synthesisen_US
dc.subjectEscherichia colien_US
dc.subjectinfrared spectroscopyen_US
dc.subjectmass spectrometryen_US
dc.subjectminimum inhibitory concentrationen_US
dc.subjectnonhumanen_US
dc.subjectPichia jadiniien_US
dc.subjectproton nuclear magnetic resonanceen_US
dc.subjectPseudomonas aeruginosaen_US
dc.titleSynthesis and antimicrobial activity of 2-substituted-3-acetyl thiazolidine -4-carbonyl-amino acid derivativesen_US
dc.typeArticleen_US
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