Synthesis and antimicrobial activity of 2-substituted-3-acetyl thiazolidine -4-carbonyl-amino acid derivatives

Abstract

The synthesis of different 2-substituted-3-acetyl-thiazolidine-4-carbonyl amino acid methyl esters (3-11) by coupling 2-substituted-3-acetyl-thiazolidine-4-carboxylic acid with amino acid methyl ester hydrochloride, corresponding amino acid hydrazides (12-20) via hydrazinolysis using hydrazine hydrate and 2-substituted- 3-acetyl-thiazolidine-4-carbonyl-N-benzylidine glycine hydrazone derivatives (21-26) were prepared via the condensation reaction of 2-substituted-3-acetyl-thiazolidine-4-carbonyl amino acid hydrazides with benzaldehyde and 4-chlorobenzaldehyde. The structures of the synthesized compounds were established by IR, 1H-NMR and MS data and elemental analysis results. The synthesized compounds were tested against different types of microorganism included gram-positive, gram-negative microorganisms Bacillius subtilis, Bacillus pumilus, Pesudomonas aeruginosa and Escherichia coli and the fungi Candida utilis. Some of the synthesized compounds were found to possess antimicrobial activities towards different type of microorganisms.