Chemical and biological assessment of Tecoma x Smithii Hort.

Abstract

Spectrophotometric quantitative determination of polyphenols, flavonoids, alkaloids, sterols, and carbohydrates of the leaves, flowers and fruits of Tecoma x smithii Will. Wats. was performed, as well as the lipoidal matter (unsaponifiable compounds and fatty acids methyl esters) that were investigated using gas chromatography-mass spectrometry (GC-MS). Representative aromatic acids where estimated for the three parts using HPLC. Polyphenols and flavonoids were most concentrated in the 70% ethanol extract of the leaves. The investigation of the ethyl acetate fraction of the 70% ethanol extract of the leaves resulted in isolation and identification of Chrysoeriol (E1), Luteolin (E2), and Caffeic acid (E3). Two other compounds were also isolated from the n-butanol fraction: Chlorogenic acid (B1) and Rutin (B2). The ethanolic and aqueous extracts of the leaves were evaluated for their acute toxicity, anti-inflammatory, antipyretic, analgesic, and anti-hyperglycemic activities. Both extracts were regarded safe and could significantly reduce the blood glucose level in alloxan- diabetic rats and showed a comparable antipyretic and analgesic effect to the reference standards used in the study. � 2019 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.