The utilization of 2-aminoprop-1-ene-1,1,3-tricarbonitrile as a precursor to quinoline, furan and thiophene derivatives with antitumor activities

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohareb, Rafat M.
dc.contributor.authorFleita, Daisy H.
dc.contributor.authorSakka, Ola K.
dc.date.accessioned2020-01-04T07:19:11Z
dc.date.available2020-01-04T07:19:11Z
dc.date.issued2011
dc.descriptionAccession Number: WOS:000297078100006en_US
dc.description.abstractThe condensation reaction of 2-aminoprop-1-ene-1,1,3-tricarbonitrile (1) with 2-acetyl-furan (2) afforded 2-amino-4-(furan-2-yl)penta-1,3-diene-1,1,3-tricarbonitrile (3). The latter compound underwent a series of heterocyclization reactions to give quinoline, furan, pyrazole and thiophene derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Three of the synthesized compounds, namely 4, 5d and 12 showed high inhibitory effects.en_US
dc.description.sponsorshipAmerican University in CairoAmerican University Cairoen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24080&tip=sid&clean=0
dc.identifier.citationCited References in Web of Science Core Collection: 17en_US
dc.identifier.doihttps://doi.org/10.1515/HC.2011.017
dc.identifier.issn0793-0283
dc.identifier.otherhttps://doi.org/10.1515/HC.2011.017
dc.identifier.urihttps://cutt.ly/Druh4iY
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER & COen_US
dc.relation.ispartofseriesHETEROCYCLIC COMMUNICATIONS;Volume: 17 Issue: 1-2 Pages: 25-31
dc.relation.urihttps://cutt.ly/wruh8LE
dc.subjectantitumor activityen_US
dc.subjectfuranen_US
dc.subjectpyrazoleen_US
dc.subjectquinolineen_US
dc.subjectthiopheneen_US
dc.titleThe utilization of 2-aminoprop-1-ene-1,1,3-tricarbonitrile as a precursor to quinoline, furan and thiophene derivatives with antitumor activitiesen_US
dc.typeArticleen_US

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