Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAbdel Rahman M.F.
dc.contributor.authorHashad I.M.
dc.contributor.authorAbou-Aisha K.
dc.contributor.authorAbdel Maksoud S.M.
dc.contributor.authorGad M.Z.
dc.contributor.otherBiochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherCairo
dc.contributor.otherEgypt; Clinical Biochemistry Unit
dc.contributor.otherFaculty of Pharmacy & Biotechnology
dc.contributor.otherGerman University in Cairo
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:26Z
dc.date.available2020-01-09T20:41:26Z
dc.date.issued2017
dc.descriptionScopus
dc.description.abstractThe aim of the current study was to assess the link between EDN K198N SNP, ET-1 serum concentration and acute myocardial infarction (AMI) in Egyptians. The study cohort consisted of 84 patients at AMI onset and 84 age-matched healthy controls. Endothelin genotypes and concentrations were determined by sequencing and ELISA, respectively. Genotype distribution was not significantly different between AMI patients and controls (P=.8341). The mean serum ET-1 concentration of patients (13.83�0.7�pg/mL) was significantly higher than controls (7.26�0.2�pg/mL) (P<.0001). ET-1 serum concentrations did not vary significantly among various EDN genotypes in patients (P=.378) and controls (P=.6164). Hence, we conclude that EDN K198N genotypes were not related to either ET-1 concentration or incidence of early-onset AMI in Egyptians. But, AMI patients had higher ET-1 concentrations than controls. � 2016 John Wiley & Sons Australia, Ltden_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=23382&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1111/1440-1681.12684
dc.identifier.doiPubMed ID 27761928
dc.identifier.issn3051870
dc.identifier.otherhttps://doi.org/10.1111/1440-1681.12684
dc.identifier.otherPubMed ID 27761928
dc.identifier.urihttps://t.ly/DXE6l
dc.language.isoEnglishen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofseriesClinical and Experimental Pharmacology and Physiology
dc.relation.ispartofseries44
dc.subjectacute myocardial infarctionen_US
dc.subjectEgyptianen_US
dc.subjectendothelinen_US
dc.subjectpolymorphismen_US
dc.subjectendothelinen_US
dc.subjectendothelin 1en_US
dc.subjectendothelin 1en_US
dc.subjectacute heart infarctionen_US
dc.subjectadulten_US
dc.subjectcontrolled studyen_US
dc.subjectEgyptianen_US
dc.subjectfemaleen_US
dc.subjectgene frequencyen_US
dc.subjectgenotypeen_US
dc.subjecthumanen_US
dc.subjectincidenceen_US
dc.subjectLetteren_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectprotein blood levelen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectblooden_US
dc.subjectEgypten_US
dc.subjectgenetic linkageen_US
dc.subjectgeneticsen_US
dc.subjectmiddle ageden_US
dc.subjectMyocardial Infarctionen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectAdulten_US
dc.subjectEgypten_US
dc.subjectEndothelin-1en_US
dc.subjectFemaleen_US
dc.subjectGenetic Linkageen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectMyocardial Infarctionen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.titleAssessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptiansen_US
dc.typeLetteren_US
dcterms.isReferencedByIshikawa, T., Yanagisawa, M., Kimura, S., Goto, K., Masaki, T., Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria (1988) Am J Physiol, 2554, pp. H970-H973; Zeiher, A.M., Goebel, H., Schachinger, V., Ihling, C., Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque. A clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina (1995) Circulation, 914, pp. 941-947; Woods, M., Mitchell, J.A., Wood, E.G., Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme (1999) Mol Pharmacol, 555, pp. 902-909; Tiret, L., Poirier, O., Hallet, V., The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people (1999) Hypertension, 335, pp. 1169-1174; Buhler, K., Ufer, M., Muller-Marbach, A., Risk of coronary artery disease as influenced by variants of the human endothelin and endothelin-converting enzyme genes (2007) Pharmacogenet Genomics, 171, pp. 77-83; Popov, A.F., Schulz, E.G., Hinz, J., Impact of endothelin-1 Lys198Asn polymorphism on coronary artery disease and endorgan damage in hypertensives (2008) Coron Artery Dis, 197, pp. 429-434; Palacin, M., Rodriguez-Pascual, F., Reguero, J.R., Lack of association between endothelin-1 gene variants and myocardial infarction (2009) J Atheroscler Thromb, 164, pp. 388-395; Miyauchi, T., Yanagisawa, M., Tomizawa, T., Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction (1989) Lancet, 28653, pp. 53-54; Stewart, D.J., Kubac, G., Costello, K.B., Cernacek, P., Increased plasma endothelin-1 in the early hours of acute myocardial infarction (1991) J Am Coll Cardiol, 181, pp. 38-43; Tomoda, H., Plasma endothelin-1 in acute myocardial infarction with heart failure (1993) Am Heart J, 1253, pp. 667-672; Hoffmann, E., Assennato, P., Donatelli, M., Colletti, I., Valenti, T.M., Plasma endothelin-1 levels in patients with angina pectoris and normal coronary angiograms (1998) Am Heart J, 1354, pp. 684-688; Yip, H.K., Wu, C.J., Chang, H.W., Prognostic value of circulating levels of endothelin-1 in patients after acute myocardial infarction undergoing primary coronary angioplasty (2005) Chest, 1275, pp. 1491-1497; OmLand, T., Lie, R.T., Aakvaag, A., Aarsland, T., Dickstein, K., Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction (1994) Circulation, 894, pp. 1573-1579; Shah, R., Endothelins in health and disease (2007) Eur J Intern Med, 184, pp. 272-282; Donato, A.J., Gano, L.B., Eskurza, I., Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase (2009) Am J Physiol Heart Circ Physiol, 2971, pp. H425-H432; Donato, A.J., Lesniewski, L.A., Delp, M.D., The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles (2005) Cardiovasc Res, 662, pp. 393-401; Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T., Holtz, J., Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells (2001) Biochem Biophys Res Commun, 2844, pp. 961-965; Rajput, C., Najib, S., Norboo, T., Afrin, F., Qadar Pasha, M.A., Endothelin-1 gene variants and levels associate with adaptation to hypobaric hypoxia in high-altitude natives (2006) Biochem Biophys Res Commun, 3414, pp. 1218-1224; Barden, A.E., Herbison, C.E., Beilin, L.J., Michael, C.A., Walters, B.N., Van Bockxmeer, F.M., Association between the endothelin-1 gene Lys198Asn polymorphism blood pressure and plasma endothelin-1 levels in normal and pre-eclamptic pregnancy (2001) J Hypertens, 1910, pp. 1775-1782; Tanaka, C., Kamide, K., Takiuchi, S., Kawano, Y., Miyata, T., Evaluation of the Lys198Asn and -134delA genetic polymorphisms of the endothelin-1 gene (2004) Hypertens Res, 275, pp. 367-371
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