Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians
Date
2017
Authors
Abdel Rahman M.F.
Hashad I.M.
Abou-Aisha K.
Abdel Maksoud S.M.
Gad M.Z.
Journal Title
Journal ISSN
Volume Title
Type
Letter
Publisher
Blackwell Publishing
Series Info
Clinical and Experimental Pharmacology and Physiology
44
44
Scientific Journal Rankings
Abstract
The aim of the current study was to assess the link between EDN K198N SNP, ET-1 serum concentration and acute myocardial infarction (AMI) in Egyptians. The study cohort consisted of 84 patients at AMI onset and 84 age-matched healthy controls. Endothelin genotypes and concentrations were determined by sequencing and ELISA, respectively. Genotype distribution was not significantly different between AMI patients and controls (P=.8341). The mean serum ET-1 concentration of patients (13.83�0.7�pg/mL) was significantly higher than controls (7.26�0.2�pg/mL) (P<.0001). ET-1 serum concentrations did not vary significantly among various EDN genotypes in patients (P=.378) and controls (P=.6164). Hence, we conclude that EDN K198N genotypes were not related to either ET-1 concentration or incidence of early-onset AMI in Egyptians. But, AMI patients had higher ET-1 concentrations than controls. � 2016 John Wiley & Sons Australia, Ltd
Description
Scopus
Keywords
acute myocardial infarction, Egyptian, endothelin, polymorphism, endothelin, endothelin 1, endothelin 1, acute heart infarction, adult, controlled study, Egyptian, female, gene frequency, genotype, human, incidence, Letter, major clinical study, male, protein blood level, single nucleotide polymorphism, blood, Egypt, genetic linkage, genetics, middle aged, Myocardial Infarction, single nucleotide polymorphism, Adult, Egypt, Endothelin-1, Female, Genetic Linkage, Humans, Male, Middle Aged, Myocardial Infarction, Polymorphism, Single Nucleotide