Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAli M.A.
dc.contributor.authorMatboli M.
dc.contributor.authorEl-Khazragy N.
dc.contributor.authorSaber O.
dc.contributor.authorEl-Nakeep S.
dc.contributor.authorAbdelzaher H.M.
dc.contributor.authorShafei A.E.-S.
dc.contributor.authorMostafa R.
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.date.accessioned2020-01-09T20:40:58Z
dc.date.available2020-01-09T20:40:58Z
dc.date.issued2018-02-14
dc.descriptionSJR 2024 0.493 Q3 H-Index 59
dc.description.abstractAim: We aimed to examine the statistical association between serum expression of miRNA 661 (miR-661) and ATG-4B mRNA and hepatocellular carcinoma (HCC) based on in silico data analysis followed by clinical validation. Patients & methods: Quantitative reverse-transcriptase real-time PCR was used to examine the expression of miR-661 and ATG-4B mRNA in the sera of HCC patients versus control. Results: The expression of miR-661 and ATG-4B mRNA was positive in 97.14 and 77.14%, respectively, in HCC patients. The survival analysis showed that ATG-4B mRNA was an independent prognostic factor. Conclusion: Our data are the first report of its kind regarding the considerable clinical significance of miR-661 and ATG-4B mRNA in HCC patients.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=11300153402&tip=sid&clean=0
dc.identifier.citationAli, M. A., Marwa Matboli, Nashwa El-Khazragy, Saber, O., El-Nakeep, S., Abdelzaher, H. M., Ayman El-Sayed Shafei, & Mostafa, R. (2018). Investigating MIRNA-661 and ATG4-B MRNA Expression as Potential Biomarkers for Hepatocellular Carcinoma. Biomarkers in Medicine, 12(3), 245–256. https://doi.org/10.2217/bmm-2017-0273 ‌
dc.identifier.doihttps://doi.org/10.2217/bmm-2017-0273
dc.identifier.issn17520363
dc.identifier.otherhttps://doi.org/10.2217/bmm-2017-0273
dc.identifier.urihttps://t.ly/q2rjD
dc.language.isoEnglishen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofseriesBiomarkers in Medicine;12(3):245-256
dc.subjectATG-4B; bioinformatics; biomarkers; hepatocellular carcinoma; miR-661; prognosis.en_US
dc.titleInvestigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinomaen_US
dc.typeArticleen_US
dcterms.sourceScopus

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