Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma
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Date
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Volume Title
Publisher
Future Medicine Ltd.
Series Info
Biomarkers in Medicine
12
12
Scientific Journal Rankings
Abstract
Aim: We aimed to examine the statistical association between serum expression of miRNA 661 (miR-661) and ATG-4B mRNA and hepatocellular carcinoma (HCC) based on in silico data analysis followed by clinical validation. Patients & methods: Quantitative reverse-transcriptase real-time PCR was used to examine the expression of miR-661 and ATG-4B mRNA in the sera of HCC patients versus control. Results: The expression of miR-661 and ATG-4B mRNA was positive in 97.14 and 77.14%, respectively, in HCC patients. The survival analysis showed that ATG-4B mRNA was an independent prognostic factor. Conclusion: Our data are the first report of its kind regarding the considerable clinical significance of miR-661 and ATG-4B mRNA in HCC patients. � 2018 2018 Future Medicine Ltd.
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Scopus
Keywords
ATG-4B, bioinformatics, biomarkers, hepatocellular carcinoma, miR-661, prognosis, alanine aminotransferase, bilirubin, cysteine proteinase, messenger RNA, microRNA, microRNA 661, protein ATG 4, unclassified drug, ATG4B protein, human, autophagy related protein, cysteine proteinase, messenger RNA, microRNA, MIRN661 microRNA, human, tumor marker, adult, alanine aminotransferase blood level, area under the curve, Article, ATG4 B gene, bilirubin blood level, cancer prognosis, cancer staging, cancer survival, Child Pugh score, disease marker, female, gene, gene expression, human, liver cell carcinoma, liver cirrhosis, major clinical study, male, protein blood level, receiver operating characteristic, reverse transcription polymerase chain reaction, sensitivity and specificity, survival rate, blood, case control study, genetics, liver cell carcinoma, liver tumor, metabolism, middle aged, pathology, prognosis, upregulation, Area Under Curve, Autophagy-Related Proteins, Biomarkers, Tumor, Carcinoma, Hepatocellular, Case-Control Studies, Cysteine Endopeptidases, Female, Humans, Liver Neoplasms, Male, MicroRNAs, Middle Aged, Neoplasm Staging, Prognosis, RNA, Messenger, ROC Curve, Up-Regulation