The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohareb R.M.
dc.contributor.authorMohamed A.A.
dc.contributor.otherDepartment of Organic Chemistry
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherOctober City
dc.contributor.otherAR
dc.contributor.otherEgypt; Department of Chemistry
dc.contributor.otherFaculty of Science
dc.contributor.otherCairo University
dc.contributor.otherGiza
dc.contributor.otherAR
dc.contributor.otherEgypt; National Organization for Drug Control and Research (NODCAR)
dc.contributor.otherP.O. 29
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:33Z
dc.date.available2020-01-25T19:58:33Z
dc.date.issued2010
dc.descriptionScopus
dc.description.abstractNew approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects. � 2010 by the authors.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=26370&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.3390/molecules15053602
dc.identifier.doiPubMed ID 20657502
dc.identifier.issn14203049
dc.identifier.otherhttps://doi.org/10.3390/molecules15053602
dc.identifier.otherPubMed ID 20657502
dc.identifier.urihttps://t.ly/epMqO
dc.language.isoEnglishen_US
dc.relation.ispartofseriesMolecules
dc.relation.ispartofseries15
dc.subject1,3,4-triazineen_US
dc.subjectAntitumoren_US
dc.subjectHydrazide-hydrazoneen_US
dc.subjectPyridazineen_US
dc.subjectPyridineen_US
dc.subjectacetohydrazideen_US
dc.subjectacetophenoneen_US
dc.subjectacetophenone derivativeen_US
dc.subjectantineoplastic agenten_US
dc.subjectheterocyclic compounden_US
dc.subjecthydrazine derivativeen_US
dc.subjectpyridineen_US
dc.subjectpyridine derivativeen_US
dc.subjecttriazine derivativeen_US
dc.subjectacetophenone derivativeen_US
dc.subjectantineoplastic agenten_US
dc.subjectheterocyclic compounden_US
dc.subjecthydrazine derivativeen_US
dc.subjectarticleen_US
dc.subjectchemistryen_US
dc.subjectdrug screeningen_US
dc.subjecthumanen_US
dc.subjectstructure activity relationen_US
dc.subjectsynthesisen_US
dc.subjecttumor cell cultureen_US
dc.subjectchemistryen_US
dc.subjectsynthesisen_US
dc.subjectAcetophenonesen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectDrug Screening Assays, Antitumoren_US
dc.subjectHeterocyclic Compoundsen_US
dc.subjectHumansen_US
dc.subjectHydrazinesen_US
dc.subjectPyridinesen_US
dc.subjectStructure-Activity Relationshipen_US
dc.subjectTriazinesen_US
dc.subjectTumor Cells, Cultureden_US
dc.subjectAcetophenonesen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectDrug Screening Assays, Antitumoren_US
dc.subjectHeterocyclic Compoundsen_US
dc.subjectHumansen_US
dc.subjectHydrazinesen_US
dc.subjectPyridinesen_US
dc.subjectStructure-Activity Relationshipen_US
dc.subjectTriazinesen_US
dc.subjectTumor Cells, Cultureden_US
dc.titleThe Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activityen_US
dc.typeArticleen_US
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