The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohareb R.M.
dc.contributor.authorMohamed A.A.
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.date.accessioned2020-01-25T19:58:33Z
dc.date.available2020-01-25T19:58:33Z
dc.date.issued2010-05-17
dc.descriptionSJR 2024 0.865 Q1 H-Index 261
dc.description.abstractNew approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=26370&tip=sid&clean=0
dc.identifier.citationMohareb, R. M., & Mohamed, A. A. (2010). The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity. Molecules, 15(5), 3602–3617. https://doi.org/10.3390/molecules15053602 ‌
dc.identifier.doihttps://doi.org/10.3390/molecules15053602
dc.identifier.issn14203049
dc.identifier.otherhttps://doi.org/10.3390/molecules15053602
dc.identifier.urihttps://t.ly/epMqO
dc.language.isoEnglishen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofseriesMolecules ; 2010, 15, 3602-3617
dc.subjecthydrazide-hydrazone; 1,3,4-triazine; pyridine; pyridazine; antitumor en_US
dc.titleThe Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activityen_US
dc.typeArticleen_US
dcterms.sourceScopus

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