The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity
Date
2010
Authors
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Series Info
Molecules
15
15
Scientific Journal Rankings
Abstract
New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects. � 2010 by the authors.
Description
Scopus
Keywords
1,3,4-triazine, Antitumor, Hydrazide-hydrazone, Pyridazine, Pyridine, acetohydrazide, acetophenone, acetophenone derivative, antineoplastic agent, heterocyclic compound, hydrazine derivative, pyridine, pyridine derivative, triazine derivative, acetophenone derivative, antineoplastic agent, heterocyclic compound, hydrazine derivative, article, chemistry, drug screening, human, structure activity relation, synthesis, tumor cell culture, chemistry, synthesis, Acetophenones, Antineoplastic Agents, Drug Screening Assays, Antitumor, Heterocyclic Compounds, Humans, Hydrazines, Pyridines, Structure-Activity Relationship, Triazines, Tumor Cells, Cultured, Acetophenones, Antineoplastic Agents, Drug Screening Assays, Antitumor, Heterocyclic Compounds, Humans, Hydrazines, Pyridines, Structure-Activity Relationship, Triazines, Tumor Cells, Cultured