The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity
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Molecules
15
15
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Abstract
New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects. � 2010 by the authors.
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Keywords
1,3,4-triazine, Antitumor, Hydrazide-hydrazone, Pyridazine, Pyridine, acetohydrazide, acetophenone, acetophenone derivative, antineoplastic agent, heterocyclic compound, hydrazine derivative, pyridine, pyridine derivative, triazine derivative, acetophenone derivative, antineoplastic agent, heterocyclic compound, hydrazine derivative, article, chemistry, drug screening, human, structure activity relation, synthesis, tumor cell culture, chemistry, synthesis, Acetophenones, Antineoplastic Agents, Drug Screening Assays, Antitumor, Heterocyclic Compounds, Humans, Hydrazines, Pyridines, Structure-Activity Relationship, Triazines, Tumor Cells, Cultured, Acetophenones, Antineoplastic Agents, Drug Screening Assays, Antitumor, Heterocyclic Compounds, Humans, Hydrazines, Pyridines, Structure-Activity Relationship, Triazines, Tumor Cells, Cultured