The potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicity

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorDkhil M.A.
dc.contributor.authorAl-Quraishy S.
dc.contributor.authorDiab M.M.S.
dc.contributor.authorOthman M.S.
dc.contributor.authorAref A.M.
dc.contributor.authorMoneim A.E.A.
dc.contributor.otherDepartment of Zoology
dc.contributor.otherCollege of Science
dc.contributor.otherKing Saud University
dc.contributor.otherRiyadh
dc.contributor.otherSaudi Arabia; Department of Zoology and Entomology
dc.contributor.otherFaculty of Science
dc.contributor.otherHelwan University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Molecular Drug Evaluation
dc.contributor.otherNational Organization for Drug Control and Research (NODCAR)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Biochemistry and Molecular Biology
dc.contributor.otherFaculty of Biotechnology
dc.contributor.otherModern Sciences and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Biological Science
dc.contributor.otherFaculty of Dentistry
dc.contributor.otherModern Sciences and Arts University (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Biochemistry and Molecular Biology
dc.contributor.otherAsturias Institute of Biotechnology
dc.contributor.otherUniversity of Oviedo
dc.contributor.otherOviedo
dc.contributor.otherSpain
dc.date.accessioned2020-01-09T20:42:06Z
dc.date.available2020-01-09T20:42:06Z
dc.date.issued2014
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractThis study aimed to investigate the potential protective role of Physalis peruviana L. (family Solanaceae) against cadmium-induced hepatorenal toxicity in Wistar rats. Herein, cadmium chloride (CdCl2) (6.5mg/kg bwt/day) was intraperitoneally injected for 5 days, and methanolic extract of physalis (MEPh) was pre-administered to a group of Cd-treated rats by an oral administration at a daily dose of 200mg/kg bwt for 5 days. The findings revealed that CdCl2 injection induced significant decreases in kidney weight and kidney index. Cadmium intoxication increased the activities of liver enzymes and the bilirubin level, in addition to the levels of uric acid, urea and creatinine were increased in the serum. The pre-administration of MEPh alleviated hepatorenal toxicity in Cd-treated rats. Physalis was noted to play a good hepatorenal protective role, reducing lipid peroxidation, nitric oxide, and enhancing enzymatic activities and non-enzymatic antioxidant molecule, glutathione, in hepatic and renal tissues of Cd-treated rats. Moreover, physalis treatment was able to reverse the histopathological changes in liver and kidney tissues and also increased the expression of Bcl-2 protein in liver and kidney of rats. Overall, the results showed that MEPh can induce antioxidant and anti-apoptotic effects and also exerts beneficial effects for the treatment of Cd-induced hepatorenal toxicity. � 2014 Elsevier Ltd.en_US
dc.identifier.doihttps://doi.org/10.1016/j.fct.2014.09.013
dc.identifier.doiPubMedID25265456
dc.identifier.issn2786915
dc.identifier.otherhttps://doi.org/10.1016/j.fct.2014.09.013
dc.identifier.otherPubMedID25265456
dc.identifier.urihttps://t.ly/OXNWJ
dc.language.isoEnglishen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofseriesFood and Chemical Toxicology
dc.relation.ispartofseries74
dc.subjectCadmiumen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectOxidative stressen_US
dc.subjectPhysalis peruviana Len_US
dc.subjectRatsen_US
dc.subjectbilirubinen_US
dc.subjectcadmiumen_US
dc.subjectcadmium chlorideen_US
dc.subjectcreatinineen_US
dc.subjectglutathioneen_US
dc.subjectlipiden_US
dc.subjectliver enzymeen_US
dc.subjectmethanolen_US
dc.subjectnitric oxideen_US
dc.subjectPhysalis peruviana extracten_US
dc.subjectplant extracten_US
dc.subjectprotein bcl 2en_US
dc.subjectunclassified drugen_US
dc.subjectureaen_US
dc.subjecturic aciden_US
dc.subjectcadmium chlorideen_US
dc.subjectplant extracten_US
dc.subjectadulten_US
dc.subjectanimal cellen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantioxidant activityen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectbilirubin blood levelen_US
dc.subjectbody weighten_US
dc.subjectcontrolled studyen_US
dc.subjectcreatinine blood levelen_US
dc.subjectenzyme activityen_US
dc.subjectfruiten_US
dc.subjecthistopathologyen_US
dc.subjectkidney massen_US
dc.subjectlipid peroxidationen_US
dc.subjectliver protectionen_US
dc.subjectliver toxicityen_US
dc.subjectmaleen_US
dc.subjectnephrotoxicityen_US
dc.subjectnonhumanen_US
dc.subjectPhysalisen_US
dc.subjectPhysalis peruvianaen_US
dc.subjectprotein expressionen_US
dc.subjectrandomized controlled trialen_US
dc.subjectraten_US
dc.subjectrenal protectionen_US
dc.subjectSolanaceaeen_US
dc.subjecturea blood levelen_US
dc.subjecturic acid blood levelen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectanimalen_US
dc.subjectantagonists and inhibitorsen_US
dc.subjectchemically induceden_US
dc.subjectdrug effectsen_US
dc.subjectDrug-Induced Liver Injuryen_US
dc.subjectfruiten_US
dc.subjectkidneyen_US
dc.subjectliveren_US
dc.subjectoxidative stressen_US
dc.subjectpathologyen_US
dc.subjectPhysalisen_US
dc.subjectphytotherapyen_US
dc.subjectproceduresen_US
dc.subjectWistar raten_US
dc.subjectPhysalis peruvianaen_US
dc.subjectRattusen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectAnimalsen_US
dc.subjectCadmium Chlorideen_US
dc.subjectDrug-Induced Liver Injuryen_US
dc.subjectFruiten_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectMaleen_US
dc.subjectOxidative Stressen_US
dc.subjectPhysalisen_US
dc.subjectPhytotherapyen_US
dc.subjectPlant Extractsen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.titleThe potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicityen_US
dc.typeArticleen_US
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