The potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicity
Loading...
Date
2014
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Elsevier Ltd
Series Info
Food and Chemical Toxicology
74
74
Scientific Journal Rankings
Abstract
This study aimed to investigate the potential protective role of Physalis peruviana L. (family Solanaceae) against cadmium-induced hepatorenal toxicity in Wistar rats. Herein, cadmium chloride (CdCl2) (6.5mg/kg bwt/day) was intraperitoneally injected for 5 days, and methanolic extract of physalis (MEPh) was pre-administered to a group of Cd-treated rats by an oral administration at a daily dose of 200mg/kg bwt for 5 days. The findings revealed that CdCl2 injection induced significant decreases in kidney weight and kidney index. Cadmium intoxication increased the activities of liver enzymes and the bilirubin level, in addition to the levels of uric acid, urea and creatinine were increased in the serum. The pre-administration of MEPh alleviated hepatorenal toxicity in Cd-treated rats. Physalis was noted to play a good hepatorenal protective role, reducing lipid peroxidation, nitric oxide, and enhancing enzymatic activities and non-enzymatic antioxidant molecule, glutathione, in hepatic and renal tissues of Cd-treated rats. Moreover, physalis treatment was able to reverse the histopathological changes in liver and kidney tissues and also increased the expression of Bcl-2 protein in liver and kidney of rats. Overall, the results showed that MEPh can induce antioxidant and anti-apoptotic effects and also exerts beneficial effects for the treatment of Cd-induced hepatorenal toxicity. � 2014 Elsevier Ltd.
Description
Scopus
MSA Google Scholar
MSA Google Scholar
Keywords
Cadmium, Kidney, Liver, Oxidative stress, Physalis peruviana L, Rats, bilirubin, cadmium, cadmium chloride, creatinine, glutathione, lipid, liver enzyme, methanol, nitric oxide, Physalis peruviana extract, plant extract, protein bcl 2, unclassified drug, urea, uric acid, cadmium chloride, plant extract, adult, animal cell, animal experiment, animal model, animal tissue, antioxidant activity, apoptosis, Article, bilirubin blood level, body weight, controlled study, creatinine blood level, enzyme activity, fruit, histopathology, kidney mass, lipid peroxidation, liver protection, liver toxicity, male, nephrotoxicity, nonhuman, Physalis, Physalis peruviana, protein expression, randomized controlled trial, rat, renal protection, Solanaceae, urea blood level, uric acid blood level, Acute Kidney Injury, animal, antagonists and inhibitors, chemically induced, drug effects, Drug-Induced Liver Injury, fruit, kidney, liver, oxidative stress, pathology, Physalis, phytotherapy, procedures, Wistar rat, Physalis peruviana, Rattus, Acute Kidney Injury, Animals, Cadmium Chloride, Drug-Induced Liver Injury, Fruit, Kidney, Liver, Male, Oxidative Stress, Physalis, Phytotherapy, Plant Extracts, Rats, Rats, Wistar