Square-wave voltammetric determination of drospirenone and ethinylestradiol in pharmaceutical dosage form using square wave technique
dc.Affiliation | October University for modern sciences and Arts (MSA) | |
dc.contributor.author | Hassan Habib, Ibrahim | |
dc.contributor.author | Salem Rizk, Mohammed | |
dc.contributor.author | Sultan, Maha | |
dc.contributor.author | Mohamed, Dalia | |
dc.contributor.author | Moussa Tony, Rehab | |
dc.date.accessioned | 2020-01-21T07:15:34Z | |
dc.date.available | 2020-01-21T07:15:34Z | |
dc.date.issued | 2019 | |
dc.description | MSA Google Scholar | en_US |
dc.description.abstract | Cathodic voltammetric behaviors of drospirenone and ethinylestradiol were used for the simultaneous determination of both drugs in bulk and in pharmaceutical formulation (Yasmin® tablets) without the interference of excipients. The determinations were made on hanging mercury dropping electrode using square-wave technique in a voltammetric cell containing 10 mL of 0.04 mole/L Britton-Robinson. After every aliquot addition, the solution was stirred for 10 s at 1000 rpm, rested for 10 s then square wave voltammetry mode was ramped from +100 to -1700 mV with scan rate of 100 mV/s, pulse amplitude of 50 mV and measurement time of 5 ms. Several factors such as pH, type of supporting electrolyte, pulse amplitude and scan rate were studied to optimize the condition for voltammetric determination of these drugs. With optimized experimental parameters, a good linearity was obtained for both drugs over a range of 1.36×10-6 to 1.91×10-7 mole/L and 6.75×10-8 to 6.07×10-7 mol/L of drospirenone and ethinylestradiol, respectively. Characterization of the proposed method was done according to International Conference on Harmonization, Q2B: Validation of Analytical procedures. The proposed method was statistically compared with the reference method and the results revealed no significant difference regarding accuracy and precision. | en_US |
dc.description.sponsorship | Atlanta Publishing House LLC | en_US |
dc.identifier.doi | https://doi.org/10.5155/eurjchem.10.4.305-316.1901 | |
dc.identifier.issn | 2153-2249 | |
dc.identifier.other | https://doi.org/10.5155/eurjchem.10.4.305-316.1901 | |
dc.identifier.uri | https://cutt.ly/CrnF8zd | |
dc.language.iso | en | en_US |
dc.publisher | Atlanta Publishing House LLC | en_US |
dc.relation.ispartofseries | European Journal of Chemistry;VOL : 10 Isu : 4 | |
dc.subject | DISSOLUTION | en_US |
dc.subject | Voltammetry | en_US |
dc.subject | Drospirenone | en_US |
dc.subject | Ethinylestradiol | en_US |
dc.subject | Yasmin® tablets | en_US |
dc.subject | Method validation | en_US |
dc.title | Square-wave voltammetric determination of drospirenone and ethinylestradiol in pharmaceutical dosage form using square wave technique | en_US |
dc.type | Article | en_US |
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